Other disorders of white blood cells (D72) ICD-10-CM
The D72 code range covers other disorders of white blood cells with 28 ICD-10-CM diagnosis codes. 22 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Codes in the D72 Range 28 codes · 22 billable
- D72 Other disorders of white blood cellsNon-billable
- D72.0 Genetic anomalies of leukocytes
- D72.1 EosinophiliaNon-billable
- D72.10 Eosinophilia, unspecified
- D72.11 Hypereosinophilic syndrome [HES]Non-billable
- D72.110 Idiopathic hypereosinophilic syndrome [IHES]
- D72.111 Lymphocytic Variant Hypereosinophilic Syndrome [LHES]
- D72.118 Other hypereosinophilic syndrome
- D72.119 Hypereosinophilic syndrome [HES], unspecified
- D72.12 Drug rash with eosinophilia and systemic symptoms syndrome
- D72.18 Eosinophilia in diseases classified elsewhere
- D72.19 Other eosinophilia
- D72.8 Other specified disorders of white blood cellsNon-billable
- D72.81 Decreased white blood cell countNon-billable
- D72.810 Lymphocytopenia
- D72.818 Other decreased white blood cell count
- D72.819 Decreased white blood cell count, unspecified
- D72.82 Elevated white blood cell countNon-billable
- D72.820 Lymphocytosis (symptomatic)
- D72.821 Monocytosis (symptomatic)
- D72.822 Plasmacytosis
- D72.823 Leukemoid reaction
- D72.824 Basophilia
- D72.825 Bandemia
- D72.828 Other elevated white blood cell count
- D72.829 Elevated white blood cell count, unspecified
- D72.89 Other specified disorders of white blood cells
- D72.9 Disorder of white blood cells, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the D72 range.
Bordetella pertussis
A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath.
Eosinophilia
Abnormal increase of EOSINOPHILS in the blood, tissues or organs.
Eosinophilia-Myalgia Syndrome
A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)
Eosinophils
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
Hodgkin Disease
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Hypereosinophilic Syndrome
A heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. There is a massive increase in the number of EOSINOPHILS in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs.
Leukemia, Large Granular Lymphocytic
A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.
Leukemoid Reaction
A peripheral blood picture resembling that of leukemia or indistinguishable from it on the basis of morphologic appearance alone. (Dorland, 27th ed)
Leukocytosis
A transient increase in the number of leukocytes in a body fluid.
Leukopenia
A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).
Lymphocyte Depletion
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
Lymphocytosis
Excess of normal lymphocytes in the blood or in any effusion.
Lymphohistiocytosis, Hemophagocytic
A group of related disorders characterized by LYMPHOCYTOSIS; HISTIOCYTOSIS; and hemophagocytosis. The two major forms are familial and reactive.
Pertussis Toxin
One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.
Pulmonary Eosinophilia
A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.
Reed-Sternberg Cells
Large cells, usually multinucleate, whose presence is a common histologic characteristic of classical HODGKIN DISEASE.
Virulence Factors, Bordetella
A set of BACTERIAL ADHESINS and TOXINS, BIOLOGICAL produced by BORDETELLA organisms that determine the pathogenesis of BORDETELLA INFECTIONS, such as WHOOPING COUGH. They include filamentous hemagglutinin; FIMBRIAE PROTEINS; pertactin; PERTUSSIS TOXIN; ADENYLATE CYCLASE TOXIN; dermonecrotic toxin; tracheal cytotoxin; Bordetella LIPOPOLYSACCHARIDES; and tracheal colonization factor.
About the D72 Code Range
The D72 ICD-10 code section covers a range of other disorders of white blood cells, including genetic anomalies, eosinophilia, and various abnormal counts of white blood cells. These codes are used to classify specific conditions affecting the quantity or function of white blood cells that do not fall under more common categories.
This section includes codes for genetic anomalies of leukocytes such as Reticular dysgenesis and Leukocyte adhesion deficiencies (D72.0), which describe inherited defects impacting white blood cell production or function. The eosinophilia codes (D72.1 and subcodes) address elevated eosinophil levels, covering conditions from idiopathic eosinophilia to the hypereosinophilic syndrome (HES), a disorder involving excessive eosinophils that can damage organs. Additionally, the section details disorders involving decreased or elevated white blood cell counts—lymphocytopenia (D72.810), lymphocytosis (D72.820), monocytosis (D72.821), and others—each reflecting abnormal levels of specific white blood cell types. Notably, codes for drug-related reactions with eosinophilia and systemic symptoms also appear here (D72.12). Lastly, unspecified and other specified white blood cell disorders (D72.8–D72.9) cover conditions like leukemoid reactions and granulocyte abnormalities. This ICD-10 code section supports precise coding for diverse white blood cell disorders, aiding accurate diagnosis and treatment documentation.
Questions About This Page
How many billable codes are in the D72 range?
Of the 28 codes in this range, 22 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the D72 range classify?
The range classifies other disorders of white blood cells. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
