2026 ICD-10-CM Diagnosis Code D68.4Acquired coagulation factor deficiency

ICD-10-CM Codes›D50–D89›D65-D69›D68

ICD-10-CM D68.4
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D68.4 is a billable ICD-10-CM diagnosis code for acquired coagulation factor deficiency. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Coagulation and hemorrhagic disorders.

Code Identity

ICD-10-CM Code
D68.4
Billable Status
Yes — Valid for Submission
Code Describes
Acquired coagulation factor deficiency
Short Description
Acquired coagulation factor deficiency
Same as the full description in the CMS dataset.
Parent Code
D68
Other coagulation defects

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD65-D69Coagulation defects, purpura and other hemorrhagic conditions
CategoryD68Other coagulation defects
This CodeD68.4Acquired coagulation factor deficiency

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired coagulation factor deficiency
  • Acquired combined coagulation factor deficiency
  • Acquired factor II deficiency
  • Acquired factor IX deficiency disease
  • Acquired factor V deficiency disease
  • Acquired factor VII deficiency disease
  • Acquired factor VIII deficiency disease
  • Acquired factor X deficiency disease
  • Acquired factor XI deficiency disease
  • Acquired factor XII deficiency disease
  • Acquired factor XIII deficiency disease
  • Acquired hemophilia
  • Acquired prekallikrein deficiency
  • Autoimmune factor VIII deficiency
  • Blood coagulation disorder due to liver disease
  • Deficiency of coagulation factor due to liver disease
  • Deficiency of coagulation factor due to vitamin K deficiency
  • Deficiency of coagulation factor due to vitamin K malabsorption in obstructive biliary disease
  • Factor II deficiency
  • Factor V deficiency
  • Factor VII deficiency
  • Factor X deficiency
  • Factor X deficiency due to systemic amyloidosis
  • Factor XI deficiency
  • Factor XII deficiency disease
  • Factor XIII deficiency disease
  • Idiopathic factor VIII deficiency
  • Malignancy-related factor VIII deficiency
  • Prekallikrein deficiency
  • Prothrombin complex deficiency
  • Vitamin K deficiency
  • Vitamin K deficiency coagulation disorder
  • Vitamin K deficiency coagulation disorder due to malabsorption

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Deficiency of coagulation factor due to liver disease
  • Deficiency of coagulation factor due to vitamin K deficiency

Type 1 Excludes

  • vitamin K deficiency of newborn P53

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Defect, defective
      • coagulation (factor)
        • acquired
    • Defect, defective
      • coagulation (factor)
        • due to
          • liver disease
    • Defect, defective
      • coagulation (factor)
        • due to
          • vitamin K deficiency
    • Deficiency, deficient
      • AC globulin (congenital) (hereditary)
        • acquired
    • Deficiency, deficient
      • coagulation NOS
        • acquired (any)
    • Deficiency, deficient
      • coagulation NOS
        • due to
          • hyperprothrombinemia
    • Deficiency, deficient
      • coagulation NOS
        • due to
          • liver disease
    • Deficiency, deficient
      • coagulation NOS
        • due to
          • vitamin K deficiency
    • Deficiency, deficient
      • factor
        • multiple (congenital)
          • acquired
    • Deficiency, deficient
      • fibrin-stabilizing factor (congenital) (hereditary)
        • acquired
    • Deficiency, deficient
      • labile factor (congenital) (hereditary)
        • acquired
    • Deficiency, deficient
      • proaccelerin (congenital) (hereditary)
        • acquired
    • Deficiency, deficient
      • proconvertin factor (congenital) (hereditary)
        • acquired
    • Deficiency, deficient
      • prothrombin (congenital) (heredItary)
        • acquired
    • Deficiency, deficient
      • stable factor (congenital) (hereditary)
        • acquired
    • Fibrinopenia(hereditary)
      • acquired
    • Hemophilia(classical) (familial) (hereditary)
      • calcipriva
    • Hemophilia(classical) (familial) (hereditary)
      • nonfamilial
    • Hyperprothrombinemia, causing coagulation factor deficiency
    • Hypoprothrombinemia(congenital) (hereditary) (idiopathic)
      • acquired

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD006
Coagulation and hemorrhagic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Factor VII Deficiency

    an autosomal recessive characteristic or a coagulation disorder acquired in association with vitamin k deficiency. factor vii is a vitamin k dependent glycoprotein essential to the extrinsic pathway of coagulation.

  • Factor V Deficiency

    a deficiency of blood coagulation factor v (known as proaccelerin or accelerator globulin or labile factor) leading to a rare hemorrhagic tendency known as owren's disease or parahemophilia. it varies greatly in severity. factor v deficiency is an autosomal recessive trait. (dorland, 27th ed)

  • Vitamin K Deficiency

    a nutritional condition produced by a deficiency of vitamin k in the diet, characterized by an increased tendency to hemorrhage (hemorrhagic disorders). such bleeding episodes may be particularly severe in newborn infants. (from cecil textbook of medicine, 19th ed, p1182)

  • Vitamin K Deficiency Bleeding

    hemorrhage caused by vitamin k deficiency.

  • Factor X Deficiency

    blood coagulation disorder usually inherited as an autosomal recessive trait, though it can be acquired. it is characterized by defective activity in both the intrinsic and extrinsic pathways, impaired thromboplastin time, and impaired prothrombin consumption.

  • Factor XI Deficiency

    a hereditary deficiency of blood coagulation factor xi (also known as plasma thromboplastin antecedent or pta or antihemophilic factor c) resulting in a systemic blood-clotting defect called hemophilia c or rosenthal's syndrome, that may resemble classical hemophilia.

  • Acquired Factor II Deficiency|Acquired hypoprothrombinemia

    an acquired coagulation disorder characterized by the partial or complete absence of prothrombin (factor ii) activity in the blood.

  • Acquired Factor II Deficiency

    an acquired coagulation disorder characterized by the partial or complete absence of prothrombin (factor ii) activity in the blood.

  • Acquired Factor VII Deficiency

    an acquired coagulation disorder characterized by the partial or complete absence of factor vii activity in the blood.

  • Factor VII Deficiency

    a coagulation disorder characterized by the partial or complete absence of factor vii activity in the blood.

  • Hereditary Factor VII Deficiency

    a rare autosomal recessive inherited blood coagulation disorder characterized by deficiency of factor vii, resulting in bleeding.

  • Acquired Factor V Deficiency

    an acquired coagulation disorder characterized by the partial or complete absence of factor v activity in the blood.

  • Factor V Deficiency

    a coagulation disorder characterized by the partial or complete absence of factor v activity in the blood.

  • Hereditary Factor V Deficiency|Owren Disease

    a very rare autosomal recessive inherited blood coagulation disorder characterized by deficiency of factor v, resulting in bleeding.

  • Prekallikrein Deficiency

    a condition characterized by the congenital or acquired deficiency of prekallikrein. this deficiency is usually not associated with bleeding. the congenital deficiency is very rare. acquired deficiency may occur in diffuse intravascular coagulation, infections, and sickle cell disease.

  • Factor II Deficiency

    a coagulation disorder characterized by the partial or complete absence of prothrombin (factor ii) activity in the blood.

  • Hereditary Factor II Deficiency|Hereditary Hypoprothrombinemia|Hereditary Prothrombin Deficiency

    a very rare autosomal recessive inherited blood coagulation disorder characterized by deficiency of prothrombin, resulting in bleeding.

  • Acquired Factor X Deficiency

    an acquired coagulation disorder characterized by the partial or complete absence of factor x activity in the blood.

  • Factor X Deficiency

    a coagulation disorder characterized by the partial or complete absence of factor x activity in the blood.

  • Hereditary Factor X Deficiency|Stuart-Prower Factor Deficiency

    a rare autosomal recessive inherited blood coagulation disorder characterized by deficiency of factor x, resulting in bleeding.

  • Acquired Factor XI Deficiency

    an acquired coagulation disorder characterized by the partial or complete absence of factor xi activity in the blood.

  • Factor XI Deficiency

    a coagulation disorder characterized by the partial or complete absence of factor xi activity in the blood.

  • Hereditary Factor XI Deficiency|Hemophilia C|Hereditary Factor XI Deficiency Disease|Hereditary Factor XI Deficiency Disease|Hereditary factor XI deficiency

    a rare inherited bleeding disorder caused by deficiency of coagulation factor xi. it may be asymptomatic or manifest with bleeding.

Patient EducationClinical

Bleeding Disorders

Normally, if you get hurt, your body forms a blood clot to stop the bleeding. For blood to clot, your body needs cells called platelets and proteins known as clotting factors. If you have a bleeding disorder, you either do not have enough platelets or clotting factors or they don't work the way they should.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D68.4 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
286.7 Acq coagul factor defic
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D68.4Overview

Is D68.4 (Other coagulation defects) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report acquired coagulation factor deficiency on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What is the ICD-9 equivalent of D68.4?

Under the General Equivalence Mappings, acquired coagulation factor deficiency converts to ICD-9-CM 286.7 (acq coagul factor defic). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.