Other coagulation defects (D68) ICD-10-CM
The D68 code range covers other coagulation defects with 32 ICD-10-CM diagnosis codes. 25 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- abnormal coagulation profile NOS R79.1
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
Codes in the D68 Range 32 codes · 25 billable
- D68 Other coagulation defectsNon-billable
- D68.0 Von Willebrand diseaseNon-billable
- D68.00 Von Willebrand disease, unspecified
- D68.01 Von Willebrand disease, type 1
- D68.02 Von Willebrand disease, type 2Non-billable
- D68.020 Von Willebrand disease, type 2A
- D68.021 Von Willebrand disease, type 2B
- D68.022 Von Willebrand disease, type 2M
- D68.023 Von Willebrand disease, type 2N
- D68.029 Von Willebrand disease, type 2, unspecified
- D68.03 Von Willebrand disease, type 3
- D68.04 Acquired von Willebrand disease
- D68.09 Other von Willebrand disease
- D68.1 Hereditary factor XI deficiency
- D68.2 Hereditary deficiency of other clotting factors
- D68.3 Hemorrhagic disorder due to circulating anticoagulantsNon-billable
- D68.31 Hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitorsNon-billable
- D68.311 Acquired hemophilia
- D68.312 Antiphospholipid antibody with hemorrhagic disorder
- D68.318 Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
- D68.32 Hemorrhagic disorder due to extrinsic circulating anticoagulants
- D68.4 Acquired coagulation factor deficiency
- D68.5 Primary thrombophiliaNon-billable
- D68.51 Activated protein C resistance
- D68.52 Prothrombin gene mutation
- D68.59 Other primary thrombophilia
- D68.6 Other thrombophiliaNon-billable
- D68.61 Antiphospholipid syndrome
- D68.62 Lupus anticoagulant syndrome
- D68.69 Other thrombophilia
- D68.8 Other specified coagulation defects
- D68.9 Coagulation defect, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the D68 range.
Acquired Coagulation Factor Deficiency
Deficiency of a coagulation factor that is not caused by genetic alterations. Causes include vitamin K deficiency, amyloidosis, and severe liver disease.
Acquired Hemophilia
Hemophilia caused by the development of autoantibodies.
Activated Protein C Resistance
A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.
Afibrinogenemia
A deficiency or absence of FIBRINOGEN in the blood.
Antiphospholipid Syndrome
The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).
Coagulation Disorder
A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood.
Factor V Deficiency
A deficiency of blood coagulation factor V (known as proaccelerin or accelerator globulin or labile factor) leading to a rare hemorrhagic tendency known as Owren's disease or parahemophilia. It varies greatly in severity. Factor V deficiency is an autosomal recessive trait. (Dorland, 27th ed)
Factor VII Deficiency
An autosomal recessive characteristic or a coagulation disorder acquired in association with VITAMIN K DEFICIENCY. FACTOR VII is a Vitamin K dependent glycoprotein essential to the extrinsic pathway of coagulation.
Factor X Deficiency
Blood coagulation disorder usually inherited as an autosomal recessive trait, though it can be acquired. It is characterized by defective activity in both the intrinsic and extrinsic pathways, impaired thromboplastin time, and impaired prothrombin consumption.
Hereditary Factor XI Deficiency
A rare inherited bleeding disorder caused by deficiency of coagulation factor XI. It may be asymptomatic or manifest with bleeding.
Hypoprothrombinemias
Absence or reduced levels of PROTHROMBIN in the blood.
Thrombophilia
A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.
von Willebrand Disease, Type 1
A subtype of von Willebrand disease that results from a partial deficiency of VON WILLEBRAND FACTOR.
von Willebrand Disease, Type 2
A subtype of von Willebrand disease that results from qualitative deficiencies of VON WILLEBRAND FACTOR. The subtype is divided into several variants with each variant having a distinctive pattern of PLATELET-interaction.
von Willebrand Disease, Type 3
A subtype of von Willebrand disease that results from a total or near total deficiency of VON WILLEBRAND FACTOR.
von Willebrand Diseases
Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.
About the D68 Code Range
These conditions involve problems with blood clotting, including clotting factor deficiencies, bleeding linked to circulating anticoagulants, and thrombophilia, a tendency toward clot formation.
D68.0 separates von Willebrand disease by type, with further subdivisions for type 2 and a separate code for acquired disease. D68.1 identifies inherited factor XI deficiency, while D68.2 covers inherited deficiencies of other clotting factors. D68.4 identifies acquired clotting factor deficiency. Bleeding linked to circulating anticoagulants splits into intrinsic and extrinsic forms under D68.3.
D68.5 distinguishes primary thrombophilia by named condition; D68.6 identifies other thrombophilia. The remaining subdivisions distinguish other specified coagulation defects from unspecified ones.
Questions About This Page
How many billable codes are in the D68 range?
Of the 32 codes in this range, 25 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the D68 range classify?
The range classifies other coagulation defects. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
