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  2. ICD-10-CM Codes List
  3. C00–D49
  4. C15-C26
  5. Malignant neoplasm of liver and intrahepatic bile ducts (C22)

Malignant neoplasm of liver and intrahepatic bile ducts (C22)

The ICD-10 code C22 covers malignant tumors affecting the liver and intrahepatic bile ducts, including various types of liver cancers and bile duct carcinomas. These codes identify specific liver malignancies for accurate diagnosis and treatment documentation.

This section includes codes such as C22.0 for liver cell carcinoma, also known as hepatocellular carcinoma or fibrolamellar hepatocellular carcinoma, which are primary liver cancers originating from liver cells. The code C22.1 designates intrahepatic bile duct carcinoma, commonly called cholangiocarcinoma, comprising cancers arising from bile duct cells within the liver. Other codes, like C22.2 for hepatoblastoma (a liver tumor often seen in children) and C22.3 for angiosarcoma of the liver, highlight rare malignant types. Codes such as C22.7 and C22.8 capture other specified carcinomas or unspecified primary liver malignancies. Finally, C22.9 is used when the malignant liver tumor is not clearly identified as primary or secondary. Using these specific codes ensures precise classification for the ICD-10 code for liver cancer and related bile duct malignancies, assisting healthcare professionals in clinical, billing, and epidemiological tasks.

Instructional Notations

Use Additional Code

The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.

Type 1 Excludes

A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

  • malignant neoplasm of biliary tract NOS C24.9
  • secondary malignant neoplasm of liver and intrahepatic bile duct C78.7

Clinical Terms

The following clinical terms provide additional context, helping users better understand the clinical background and common associations for each diagnosis listed in this section. Including related terms alongside ICD-10-CM codes supports coders, billers, and healthcare professionals in improving accuracy, enhancing documentation, and facilitating research or patient education.

Hep G2 Cells

A human liver tumor cell line used to study a variety of liver-specific metabolic functions.

Hepatoblastoma

A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)