Malignant neoplasm of liver and intrahepatic bile ducts (C22) ICD-10-CM
The C22 code range covers malignant neoplasm of liver and intrahepatic bile ducts with 9 ICD-10-CM diagnosis codes. 8 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
- code to identify:
- alcohol abuse and dependence F10
- hepatitis B B16 B18.0 B18.1
- hepatitis C B17.1 B18.2
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Codes in the C22 Range 9 codes · 8 billable
- C22 Malignant neoplasm of liver and intrahepatic bile ductsNon-billable
- C22.0 Liver cell carcinoma
- C22.1 Intrahepatic bile duct carcinoma
- C22.2 Hepatoblastoma
- C22.3 Angiosarcoma of liver
- C22.4 Other sarcomas of liver
- C22.7 Other specified carcinomas of liver
- C22.8 Malignant neoplasm of liver, primary, unspecified as to type
- C22.9 Malignant neoplasm of liver, not specified as primary or secondary
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the C22 range.
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Hepatoblastoma
A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)
Intrahepatic Cholangiocarcinoma
A carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.
Liver Angiosarcoma
An angiosarcoma that arises from the liver.
Liver Cancer
A primary or metastatic malignant neoplasm that affects the liver.
Primary Malignant Liver Neoplasm
An epithelial or non-epithelial malignant neoplasm that arises from the liver. Representative examples include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, lymphoma, and sarcoma.
About the C22 Code Range
These cancers affect the liver or the bile ducts inside it. They sit within the larger group of digestive organ cancers.
The subdivisions distinguish liver cell cancer (C22.0) from cancer of the bile ducts inside the liver (C22.1). They also name hepatoblastoma (C22.2), liver angiosarcoma (C22.3), and other liver sarcomas (C22.4) as distinct cancers.
The remaining subdivisions distinguish other specified liver carcinomas, or cancers, (C22.7) from primary liver cancer of unspecified type (C22.8). C22.9 does not specify whether the liver cancer is primary or secondary.
Questions About This Page
How many billable codes are in the C22 range?
Of the 9 codes in this range, 8 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the C22 range classify?
The range classifies malignant neoplasm of liver and intrahepatic bile ducts. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
