Malignant neoplasm of other connective and soft tissue (C49) ICD-10-CM
The C49 code range covers malignant neoplasm of other connective and soft tissue with 24 ICD-10-CM diagnosis codes. 20 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Includes
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
- malignant neoplasm of blood vessel
- malignant neoplasm of bursa
- malignant neoplasm of cartilage
- malignant neoplasm of fascia
- malignant neoplasm of fat
- malignant neoplasm of ligament, except uterine
- malignant neoplasm of lymphatic vessel
- malignant neoplasm of muscle
- malignant neoplasm of synovia
- malignant neoplasm of tendon (sheath)
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- malignant neoplasm of cartilage (of):
- articular C40 C41
- larynx C32.3
- nose C30.0
- malignant neoplasm of connective tissue of breast C50
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
Codes in the C49 Range 24 codes · 20 billable
- C49 Malignant neoplasm of other connective and soft tissueNon-billable
- C49.0 Malignant neoplasm of connective and soft tissue of head, face and neck
- C49.1 Malignant neoplasm of connective and soft tissue of upper limb, including shoulderNon-billable
- C49.10 Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder
- C49.11 Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder
- C49.12 Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder
- C49.2 Malignant neoplasm of connective and soft tissue of lower limb, including hipNon-billable
- C49.20 Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip
- C49.21 Malignant neoplasm of connective and soft tissue of right lower limb, including hip
- C49.22 Malignant neoplasm of connective and soft tissue of left lower limb, including hip
- C49.3 Malignant neoplasm of connective and soft tissue of thorax
- C49.4 Malignant neoplasm of connective and soft tissue of abdomen
- C49.5 Malignant neoplasm of connective and soft tissue of pelvis
- C49.6 Malignant neoplasm of connective and soft tissue of trunk, unspecified
- C49.8 Malignant neoplasm of overlapping sites of connective and soft tissue
- C49.9 Malignant neoplasm of connective and soft tissue, unspecified
- C49.A Gastrointestinal stromal tumorNon-billable
- C49.A0 Gastrointestinal stromal tumor, unspecified site
- C49.A1 Gastrointestinal stromal tumor of esophagus
- C49.A2 Gastrointestinal stromal tumor of stomach
- C49.A3 Gastrointestinal stromal tumor of small intestine
- C49.A4 Gastrointestinal stromal tumor of large intestine
- C49.A5 Gastrointestinal stromal tumor of rectum
- C49.A9 Gastrointestinal stromal tumor of other sites
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the C49 range.
Colorectal Gastrointestinal Stromal Tumor
A gastrointestinal stromal tumor that arises from the colon or rectum. The majority of cases have spindle cell morphology.
Esophageal Gastrointestinal Stromal Tumor
A gastrointestinal stromal tumor that arises from the esophagus. The majority are spindle cell tumors that exhibit high mitotic activity and affect the distal esophagus.
Gastric Gastrointestinal Stromal Tumor
A gastrointestinal stromal tumor that arises from the stomach. This category covers a spectrum of benign to malignant soft tissue neoplasms and includes most gastric smooth muscle tumors, leiomyoblastomas, and tumors formerly called gastrointestinal autonomic nerve tumors.
Gastrointestinal Stromal Tumors
All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).
Rectal Gastrointestinal Stromal Tumor
A gastrointestinal stromal tumor that arises from the rectum.
Small Intestinal Gastrointestinal Stromal Tumor
A gastrointestinal stromal tumor that arises from the small intestine. It usually affects adults over fifty years of age. The majority of cases have spindle cell morphology. The prognosis depends on the tumor size and the mitotic activity.
About the C49 Code Range
These cancers affect connective and soft tissue in different parts of the body. The category also includes gastrointestinal stromal tumors.
Most subdivisions of C49 distinguish where the cancer is located, such as the head, trunk, or limbs. The upper-limb and lower-limb subdivisions also distinguish right, left, and unspecified sides. Other subdivisions identify overlapping sites or an unspecified site.
C49.A groups gastrointestinal stromal tumors by site, including the esophagus, stomach, intestines, and rectum.
Questions About This Page
How many billable codes are in the C49 range?
Of the 24 codes in this range, 20 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the C49 range classify?
The range classifies malignant neoplasm of other connective and soft tissue. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
