Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue (C96) ICD-10-CM
The C96 code range covers other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue with 13 ICD-10-CM diagnosis codes. 11 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues Z85.79
Codes in the C96 Range 13 codes · 11 billable
- C96 Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissueNon-billable
- C96.0 Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis
- C96.2 Malignant mast cell neoplasmNon-billable
- C96.20 Malignant mast cell neoplasm, unspecified
- C96.21 Aggressive systemic mastocytosis
- C96.22 Mast cell sarcoma
- C96.29 Other malignant mast cell neoplasm
- C96.4 Sarcoma of dendritic cells (accessory cells)
- C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis
- C96.6 Unifocal Langerhans-cell histiocytosis
- C96.9 Malignant neoplasm of lymphoid, hematopoietic and related tissue, unspecified
- C96.A Histiocytic sarcoma
- C96.Z Other specified malignant neoplasms of lymphoid, hematopoietic and related tissue
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the C96 range.
Aggressive Systemic Mastocytosis
A form of systemic mastocytosis in which patients have impaired organ functions due to multifocal infiltrates of pathological MAST CELLS in bone marrow, liver, spleen, gastrointestinal tract, or skeletal system. The cytomorphology shows a low to high grade.
Dendritic Cell Tumor, Not Otherwise Specified
A dendritic cell neoplasm that does not fall into well-defined categories or shows hybrid features.
Eosinophilic Granuloma
A clinical variant of Langerhans cell histiocytosis characterized by unifocal involvement of a bone (most often), skin, or lung. Patients are usually older children or adults usually presenting with a lytic bone lesion. The etiology is unknown. Morphologically, eosinophilic granuloma is characterized by the presence of Langerhans cells in a characteristic milieu which includes histiocytes, eosinophils, neutrophils, and small, mature lymphocytes.
Hand-Schuller-Christian Disease
A multifocal, unisystem form of Langerhans-cell histiocytosis. There is involvement of multiple sites in one organ system, most frequently the bone. Patients are usually young children presenting with multiple destructive bone lesions.
Hematopoietic and Lymphoid Cell Neoplasm
A neoplasm that arises from hematopoietic and lymphoid cells. Representative examples include myeloproliferative neoplasms, myelodysplastic syndromes, leukemias, Hodgkin lymphomas, and non-Hodgkin lymphomas.
Histiocytic Sarcoma
Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.
Letterer-Siwe Disease
A multifocal, multisystem form of Langerhans-cell histiocytosis. There is involvement of multiple organ systems including the bones, skin, liver, spleen, and lymph nodes. Patients are usually infants presenting with fever, hepatosplenomegaly, lymphadenopathy, bone and skin lesions, and pancytopenia.
Malignant Mastocytosis
A group of malignant mast cell disorders including aggressive systemic mastocytosis, mast cell leukemia, mast cell sarcoma, and systemic mastocytosis with an associated myeloid neoplasm. Individuals with advanced systemic mastocytosis have a reduced life expectancy, with median survival measured in months to years.
Mast-Cell Sarcoma
A unifocal malignant tumor that consists of atypical pathological MAST CELLS without systemic involvement. It causes local destructive growth in organs other than in skin or bone marrow.
About the C96 Code Range
These cancers involve lymph-related, blood-forming, or related tissue and fall into other or unspecified groups.
Langerhans-cell histiocytosis is separated by its spread: C96.6 names one site, C96.5 names multiple sites in one body system, and C96.0 names multiple body systems.
The mast cell group C96.2 separates aggressive systemic mastocytosis, mast cell sarcoma, other malignant mast cell tumors, and an unspecified malignant mast cell tumor. Separate codes identify dendritic cell sarcoma and histiocytic sarcoma. The remaining codes distinguish other specified cancers from unspecified cancers of these tissues.
Questions About This Page
How many billable codes are in the C96 range?
Of the 13 codes in this range, 11 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the C96 range classify?
The range classifies other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
