Malignant neoplasm of breast (C50) ICD-10-CM
The C50 code range covers malignant neoplasm of breast with 86 ICD-10-CM diagnosis codes. 57 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Includes
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
- connective tissue of breast
- Paget's disease of breast
- Paget's disease of nipple
Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
- code to identify estrogen, and other hormones and factors receptor status Z17
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Codes in the C50 Range 86 codes · 57 billable
- C50 Malignant neoplasm of breastNon-billable
- C50.0 Malignant neoplasm of nipple and areolaNon-billable
- C50.01 Malignant neoplasm of nipple and areola, femaleNon-billable
- C50.011 Malignant neoplasm of nipple and areola, right female breast
- C50.012 Malignant neoplasm of nipple and areola, left female breast
- C50.019 Malignant neoplasm of nipple and areola, unspecified female breast
- C50.02 Malignant neoplasm of nipple and areola, maleNon-billable
- C50.021 Malignant neoplasm of nipple and areola, right male breast
- C50.022 Malignant neoplasm of nipple and areola, left male breast
- C50.029 Malignant neoplasm of nipple and areola, unspecified male breast
- C50.1 Malignant neoplasm of central portion of breastNon-billable
- C50.11 Malignant neoplasm of central portion of breast, femaleNon-billable
- C50.111 Malignant neoplasm of central portion of right female breast
- C50.112 Malignant neoplasm of central portion of left female breast
- C50.119 Malignant neoplasm of central portion of unspecified female breast
- C50.12 Malignant neoplasm of central portion of breast, maleNon-billable
- C50.121 Malignant neoplasm of central portion of right male breast
- C50.122 Malignant neoplasm of central portion of left male breast
- C50.129 Malignant neoplasm of central portion of unspecified male breast
- C50.2 Malignant neoplasm of upper-inner quadrant of breastNon-billable
- C50.21 Malignant neoplasm of upper-inner quadrant of breast, femaleNon-billable
- C50.211 Malignant neoplasm of upper-inner quadrant of right female breast
- C50.212 Malignant neoplasm of upper-inner quadrant of left female breast
- C50.219 Malignant neoplasm of upper-inner quadrant of unspecified female breast
- C50.22 Malignant neoplasm of upper-inner quadrant of breast, maleNon-billable
- C50.221 Malignant neoplasm of upper-inner quadrant of right male breast
- C50.222 Malignant neoplasm of upper-inner quadrant of left male breast
- C50.229 Malignant neoplasm of upper-inner quadrant of unspecified male breast
- C50.3 Malignant neoplasm of lower-inner quadrant of breastNon-billable
- C50.31 Malignant neoplasm of lower-inner quadrant of breast, femaleNon-billable
- C50.311 Malignant neoplasm of lower-inner quadrant of right female breast
- C50.312 Malignant neoplasm of lower-inner quadrant of left female breast
- C50.319 Malignant neoplasm of lower-inner quadrant of unspecified female breast
- C50.32 Malignant neoplasm of lower-inner quadrant of breast, maleNon-billable
- C50.321 Malignant neoplasm of lower-inner quadrant of right male breast
- C50.322 Malignant neoplasm of lower-inner quadrant of left male breast
- C50.329 Malignant neoplasm of lower-inner quadrant of unspecified male breast
- C50.4 Malignant neoplasm of upper-outer quadrant of breastNon-billable
- C50.41 Malignant neoplasm of upper-outer quadrant of breast, femaleNon-billable
- C50.411 Malignant neoplasm of upper-outer quadrant of right female breast
- C50.412 Malignant neoplasm of upper-outer quadrant of left female breast
- C50.419 Malignant neoplasm of upper-outer quadrant of unspecified female breast
- C50.42 Malignant neoplasm of upper-outer quadrant of breast, maleNon-billable
- C50.421 Malignant neoplasm of upper-outer quadrant of right male breast
- C50.422 Malignant neoplasm of upper-outer quadrant of left male breast
- C50.429 Malignant neoplasm of upper-outer quadrant of unspecified male breast
- C50.5 Malignant neoplasm of lower-outer quadrant of breastNon-billable
- C50.51 Malignant neoplasm of lower-outer quadrant of breast, femaleNon-billable
- C50.511 Malignant neoplasm of lower-outer quadrant of right female breast
- C50.512 Malignant neoplasm of lower-outer quadrant of left female breast
- C50.519 Malignant neoplasm of lower-outer quadrant of unspecified female breast
- C50.52 Malignant neoplasm of lower-outer quadrant of breast, maleNon-billable
- C50.521 Malignant neoplasm of lower-outer quadrant of right male breast
- C50.522 Malignant neoplasm of lower-outer quadrant of left male breast
- C50.529 Malignant neoplasm of lower-outer quadrant of unspecified male breast
- C50.6 Malignant neoplasm of axillary tail of breastNon-billable
- C50.61 Malignant neoplasm of axillary tail of breast, femaleNon-billable
- C50.611 Malignant neoplasm of axillary tail of right female breast
- C50.612 Malignant neoplasm of axillary tail of left female breast
- C50.619 Malignant neoplasm of axillary tail of unspecified female breast
- C50.62 Malignant neoplasm of axillary tail of breast, maleNon-billable
- C50.621 Malignant neoplasm of axillary tail of right male breast
- C50.622 Malignant neoplasm of axillary tail of left male breast
- C50.629 Malignant neoplasm of axillary tail of unspecified male breast
- C50.8 Malignant neoplasm of overlapping sites of breastNon-billable
- C50.81 Malignant neoplasm of overlapping sites of breast, femaleNon-billable
- C50.811 Malignant neoplasm of overlapping sites of right female breast
- C50.812 Malignant neoplasm of overlapping sites of left female breast
- C50.819 Malignant neoplasm of overlapping sites of unspecified female breast
- C50.82 Malignant neoplasm of overlapping sites of breast, maleNon-billable
- C50.821 Malignant neoplasm of overlapping sites of right male breast
- C50.822 Malignant neoplasm of overlapping sites of left male breast
- C50.829 Malignant neoplasm of overlapping sites of unspecified male breast
- C50.9 Malignant neoplasm of breast of unspecified siteNon-billable
- C50.91 Malignant neoplasm of breast of unspecified site, femaleNon-billable
- C50.911 Malignant neoplasm of unspecified site of right female breast
- C50.912 Malignant neoplasm of unspecified site of left female breast
- C50.919 Malignant neoplasm of unspecified site of unspecified female breast
- C50.92 Malignant neoplasm of breast of unspecified site, maleNon-billable
- C50.921 Malignant neoplasm of unspecified site of right male breast
- C50.922 Malignant neoplasm of unspecified site of left male breast
- C50.929 Malignant neoplasm of unspecified site of unspecified male breast
- C50.A Malignant inflammatory neoplasm of breastNon-billable
- C50.A0 Malignant inflammatory neoplasm of unspecified breast New
- C50.A1 Malignant inflammatory neoplasm of right breast New
- C50.A2 Malignant inflammatory neoplasm of left breast New
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the C50 range.
Hereditary Breast and Ovarian Cancer Syndrome
Autosomal dominant HEREDITARY CANCER SYNDROME in which a mutation most often in either BRCA1 or BRCA2 is associated with a significantly increased risk for breast and ovarian cancers.
Neoplastic Syndromes, Hereditary
The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.
About the C50 Code Range
The ICD-10 code C50 series is specifically used to classify various forms of malignant neoplasms (cancers) of the breast. These codes cover malignant tumors originating in different breast regions, including the nipple, areola, and distinct quadrants of both female and male breasts.
The detailed ICD-10 codes for breast cancer reflect precise locations such as the nipple and areola (C50.0x), central portion (C50.1x), and upper-inner quadrant (C50.2x) among others. Some codes specify the affected side — right, left, or unspecified. Notably, codes like C50.019 and C50.029 include conditions commonly known under synonyms like Primary Paget disease of nipple or Malignant neoplasm of areola, helping coders link common terms to the official classification. Additionally, unspecified site codes (e.g., C50.9x) encompass broader types of breast cancer, including variants such as infiltrating duct carcinoma, lobular carcinoma, and triple-negative breast cancer. This range of codes supports accurate documentation for malignant breast tumors by region, sex, and special recognized synonyms.
Questions About This Page
How many billable codes are in the C50 range?
Of the 86 codes in this range, 57 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the C50 range classify?
The range classifies malignant neoplasm of breast. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
