ICD-10-CM Code C49.A

Gastrointestinal stromal tumor

Version 2021 Non-Billable Code

Not Valid for Submission

C49.A is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of gastrointestinal stromal tumor. The code is NOT valid for the year 2021 for the submission of HIPAA-covered transactions.

ICD-10:C49.A
Short Description:Gastrointestinal stromal tumor
Long Description:Gastrointestinal stromal tumor

Consider the following ICD-10 codes with a higher level of specificity:

  • C49.A0 - ... unspecified site
  • C49.A1 - Gastrointestinal stromal tumor of esophagus
  • C49.A2 - Gastrointestinal stromal tumor of stomach
  • C49.A3 - Gastrointestinal stromal tumor of small intestine
  • C49.A4 - Gastrointestinal stromal tumor of large intestine
  • C49.A5 - Gastrointestinal stromal tumor of rectum
  • C49.A9 - Gastrointestinal stromal tumor of other sites

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code C49.A are found in the index:


Clinical Information

  • GASTROINTESTINAL STROMAL TUMORS-. all tumors in the gastrointestinal tract arising from mesenchymal cells mesoderm except those of smooth muscle cells leiomyoma or schwann cells schwannoma.

Code Classification

  • Neoplasms (C00–D48)
    • Malignant neoplasms of mesothelial and soft tissue (C45-C49)
      • Malignant neoplasm of other connective and soft tissue (C49)

Code History

  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients


Gastrointestinal stromal tumor A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. The tumors are thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. GISTs are usually found in adults between ages 40 and 70; rarely, children and young adults develop these tumors. The tumors can be cancerous (malignant) or noncancerous (benign).Small tumors may cause no signs or symptoms. However, some people with GISTs may experience pain or swelling in the abdomen, nausea, vomiting, loss of appetite, or weight loss. Sometimes, tumors cause bleeding, which may lead to low red blood cell counts (anemia) and, consequently, weakness and tiredness. Bleeding into the intestinal tract may cause black and tarry stools, and bleeding into the throat or stomach may cause vomiting of blood.Affected individuals with no family history of GIST typically have only one tumor (called a sporadic GIST). People with a family history of GISTs (called familial GISTs) often have multiple tumors and additional signs or symptoms, including noncancerous overgrowth (hyperplasia) of other cells in the gastrointestinal tract and patches of dark skin on various areas of the body. Some affected individuals have a skin condition called urticaria pigmentosa (also known as cutaneous mastocytosis), which is characterized by raised patches of brownish skin that sting or itch when touched.
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