Neoplasm of uncertain behavior of other and unspecified sites (D48)
Clinical Information
Angiolymphoid Hyperplasia with Eosinophilia - Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells.
APUD Cells - Cells with the capacity to take up and decarboxylate the amine precursors DIHYDROXYPHENYLALANINE or 5-HYDROXYTRYPTOPHAN. This is a property of endocrine cells of neural and non-neural origin. APUDOMA is a general term collectively applied to tumors associated with APUD cells.
Apudoma - A general term collectively applied to tumors associated with the APUD CELLS series, irrespective of their specific identification.
Carcinoid Tumor - A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Chondromatosis - Multiple formation of chondromas. (Dorland, 27th ed)
Chondromatosis, Synovial - Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.
Ganglioglioma - Rare indolent tumors comprised of neoplastic glial and neuronal cells which occur primarily in children and young adults. Benign lesions tend to be associated with long survival unless the tumor degenerates into a histologically malignant form. They tend to occur in the optic nerve and white matter of the brain and spinal cord.
Giant Cell Tumor of Bone - A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)
Hemangioblastoma - A benign tumor of the nervous system that may occur sporadically or in association with VON HIPPEL-LINDAU DISEASE. It accounts for approximately 2% of intracranial tumors, arising most frequently in the cerebellar hemispheres and vermis. Histologically, the tumors are composed of multiple capillary and sinusoidal channels lined with endothelial cells and clusters of lipid-laden pseudoxanthoma cells. Usually solitary, these tumors can be multiple and may also occur in the brain stem, spinal cord, retina, and supratentorial compartment. Cerebellar hemangioblastomas usually present in the third decade with INTRACRANIAL HYPERTENSION, and ataxia. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2071-2)
Hemangioendothelioma - A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
Hemangioendothelioma, Epithelioid - A tumor of medium-to-large veins, composed of plump-to-spindled endothelial cells that bulge into vascular spaces in a tombstone-like fashion. These tumors are thought to have "borderline" aggression, where one-third develop local recurrences, but only rarely metastasize. It is unclear whether the epithelioid hemangioendothelioma is truly neoplastic or an exuberant tissue reaction, nor is it clear if this is equivalent to Kimura's disease (see ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA). (Segen, Dictionary of Modern Medicine, 1992)
Hemangiopericytoma - A tumor composed of spindle cells with a rich vascular network, which apparently arises from pericytes, cells of smooth muscle origin that lie around small vessels. Benign and malignant hemangiopericytomas exist, and the rarity of these lesions has led to considerable confusion in distinguishing between benign and malignant variants. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1364)
Hypothalamic Neoplasms - Benign and malignant tumors of the HYPOTHALAMUS. Pilocytic astrocytomas and hamartomas are relatively frequent histologic types. Neoplasms of the hypothalamus frequently originate from adjacent structures, including the OPTIC CHIASM, optic nerve (see OPTIC NERVE NEOPLASMS), and pituitary gland (see PITUITARY NEOPLASMS). Relatively frequent clinical manifestations include visual loss, developmental delay, macrocephaly, and precocious puberty. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2051)
Teratoma - A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)
Instructional Notations
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- neurofibromatosis nonmalignant Q85.0
Neoplasms (C00–D49)
Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (D37-D48)
D48 Neoplasm of uncertain behavior of other and unspecified sites
- D48.0 Neoplasm of uncertain behavior of bone and articular cartilage
D48.1 Neoplasm of uncertain behavior of connective and other soft tissue NEW CODE
D48.11 Desmoid tumor NEW CODE
- D48.110 Desmoid tumor of head and neck NEW CODE
- D48.111 Desmoid tumor of chest wall NEW CODE
- D48.112 Desmoid tumor, intrathoracic NEW CODE
- D48.113 Desmoid tumor of abdominal wall NEW CODE
- D48.114 Desmoid tumor, intraabdominal NEW CODE
- D48.115 Desmoid tumor of upper extremity and shoulder girdle NEW CODE
- D48.116 Desmoid tumor of lower extremity and pelvic girdle NEW CODE
- D48.117 Desmoid tumor of back NEW CODE
- D48.118 Desmoid tumor of other site NEW CODE
- D48.119 Desmoid tumor of unspecified site NEW CODE
- D48.19 Other specified neoplasm of uncertain behavior of connective and other soft tissue NEW CODE
- D48.2 Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system
- D48.3 Neoplasm of uncertain behavior of retroperitoneum
- D48.4 Neoplasm of uncertain behavior of peritoneum
- D48.5 Neoplasm of uncertain behavior of skin
D48.6 Neoplasm of uncertain behavior of breast
- D48.60 Neoplasm of uncertain behavior of unspecified breast
- D48.61 Neoplasm of uncertain behavior of right breast
- D48.62 Neoplasm of uncertain behavior of left breast
- D48.7 Neoplasm of uncertain behavior of other specified sites
- D48.9 Neoplasm of uncertain behavior, unspecified
Neoplasm of uncertain behavior of other and unspecified sites (D48)