2026 ICD-10-CM Diagnosis Code C49Malignant neoplasm of other connective and soft tissue
C49 is a non-billable ICD-10-CM category code for malignant neoplasm of other connective and soft tissue, so it cannot be submitted on claims. Use a more specific code from this category instead, such as C49.0, C49.10, C49.11, and C49.12.
Code Identity
Code Classification
Specific Coding for Malignant neoplasm of other connective and soft tissueOverview
Non-specific codes like C49 require more characters. Use one of these billable codes instead:
Use C49.0 for Malignant neoplasm of connective and soft tissue of head, face and neck
C49.1 for Malignant neoplasm of connective and soft tissue of upper limb, including shoulder
Use C49.10 for Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder
Use C49.11 for Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder
Use C49.12 for Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder
C49.2 for Malignant neoplasm of connective and soft tissue of lower limb, including hip
Use C49.20 for Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip
Use C49.21 for Malignant neoplasm of connective and soft tissue of right lower limb, including hip
Use C49.22 for Malignant neoplasm of connective and soft tissue of left lower limb, including hip
Use C49.3 for Malignant neoplasm of connective and soft tissue of thorax
Use C49.4 for Malignant neoplasm of connective and soft tissue of abdomen
Use C49.5 for Malignant neoplasm of connective and soft tissue of pelvis
Use C49.6 for Malignant neoplasm of connective and soft tissue of trunk, unspecified
Use C49.8 for Malignant neoplasm of overlapping sites of connective and soft tissue
Use C49.9 for Malignant neoplasm of connective and soft tissue, unspecified
C49.A for Gastrointestinal stromal tumor
Use C49.A0 for Gastrointestinal stromal tumor, unspecified site
Use C49.A1 for Gastrointestinal stromal tumor of esophagus
Use C49.A2 for Gastrointestinal stromal tumor of stomach
Use C49.A3 for Gastrointestinal stromal tumor of small intestine
Use C49.A4 for Gastrointestinal stromal tumor of large intestine
Use C49.A5 for Gastrointestinal stromal tumor of rectum
Use C49.A9 for Gastrointestinal stromal tumor of other sites
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Includes
- malignant neoplasm of blood vessel
- malignant neoplasm of bursa
- malignant neoplasm of cartilage
- malignant neoplasm of fascia
- malignant neoplasm of fat
- malignant neoplasm of ligament, except uterine
- malignant neoplasm of lymphatic vessel
- malignant neoplasm of muscle
- malignant neoplasm of synovia
- malignant neoplasm of tendon (sheath)
Type 1 Excludes
- malignant neoplasm of cartilage (of):
- articular C40 C41
- larynx C32.3
- nose C30.0
- malignant neoplasm of connective tissue of breast C50
Type 2 Excludes
- Kaposi's sarcoma of soft tissue C46.1
- malignant neoplasm of heart C38.0
- malignant neoplasm of peripheral nerves and autonomic nervous system C47
- malignant neoplasm of peritoneum C48.2
- malignant neoplasm of retroperitoneum C48.0
- malignant neoplasm of uterine ligament C57.3
- mesothelioma C45
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
Patient EducationClinical
Cancer
Cancer is not just one disease but many diseases. Cancer begins in your cells, which are the building blocks of your body. Usually, your body forms new cells as needed, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should.
The full article covers:
- What is cancer?
- What are the types of cancer?
- How does cancer develop?
- What are the symptoms of cancer?
- How is cancer diagnosed?
- What are the treatments for cancer?
- Can cancer be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Code HistoryHistory
Questions About C49Overview
Is C49 (Malignant neoplasm of other connective and soft tissue) a billable code?
No. This is a category header that groups the codes for malignant neoplasm of other connective and soft tissue, and headers cannot be submitted on claims. Claims for malignant neoplasm of other connective and soft tissue need a more specific code from this category, such as C49.0, C49.10, and C49.11.
