2027 ICD-10-CM Diagnosis Code C49Malignant neoplasm of other connective and soft tissue

ICD-10-CM Codes›C00–D49›C45-C49›C49

ICD-10-CM C49
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

C49 is a non-billable ICD-10-CM category code for malignant neoplasm of other connective and soft tissue, so it cannot be submitted on claims. Use a more specific code from this category instead, such as C49.0, C49.10, C49.11, and C49.12.

Code Identity

ICD-10-CM Code
C49
Billable Status
No — Non-Billable Category
Code Describes
Malignant neoplasm of other connective and soft tissue
Short Description
Malignant neoplasm of other connective and soft tissue
Same as the full description in the CMS dataset.
Chapter
C45-C49
Malignant neoplasms of mesothelial and soft tissue

Code Classification

ChapterC00–D49Neoplasms
SectionC45-C49Malignant neoplasms of mesothelial and soft tissue
CategoryC49Malignant neoplasm of other connective and soft tissue
This CodeC49Malignant neoplasm of other connective and soft tissue

Specific Coding for Malignant neoplasm of other connective and soft tissueOverview

Non-specific codes like C49 require more characters. Use one of these billable codes instead:

  • Use C49.0 for Malignant neoplasm of connective and soft tissue of head, face and neck

  • C49.1 for Malignant neoplasm of connective and soft tissue of upper limb, including shoulder

  • Use C49.10 for Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder

  • Use C49.11 for Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder

  • Use C49.12 for Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder

  • C49.2 for Malignant neoplasm of connective and soft tissue of lower limb, including hip

  • Use C49.20 for Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip

  • Use C49.21 for Malignant neoplasm of connective and soft tissue of right lower limb, including hip

  • Use C49.22 for Malignant neoplasm of connective and soft tissue of left lower limb, including hip

  • Use C49.3 for Malignant neoplasm of connective and soft tissue of thorax

  • Use C49.4 for Malignant neoplasm of connective and soft tissue of abdomen

  • Use C49.5 for Malignant neoplasm of connective and soft tissue of pelvis

  • Use C49.6 for Malignant neoplasm of connective and soft tissue of trunk, unspecified

  • Use C49.8 for Malignant neoplasm of overlapping sites of connective and soft tissue

  • Use C49.9 for Malignant neoplasm of connective and soft tissue, unspecified

  • C49.A for Gastrointestinal stromal tumor

  • Use C49.A0 for Gastrointestinal stromal tumor, unspecified site

  • Use C49.A1 for Gastrointestinal stromal tumor of esophagus

  • Use C49.A2 for Gastrointestinal stromal tumor of stomach

  • Use C49.A3 for Gastrointestinal stromal tumor of small intestine

  • Use C49.A4 for Gastrointestinal stromal tumor of large intestine

  • Use C49.A5 for Gastrointestinal stromal tumor of rectum

  • Use C49.A9 for Gastrointestinal stromal tumor of other sites

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to C49: its own notes plus those printed at Chapter 2. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

  • malignant neoplasm of blood vessel
  • malignant neoplasm of bursa
  • malignant neoplasm of cartilage
  • malignant neoplasm of fascia
  • malignant neoplasm of fat
  • malignant neoplasm of ligament, except uterine
  • malignant neoplasm of lymphatic vessel
  • malignant neoplasm of muscle
  • malignant neoplasm of synovia
  • malignant neoplasm of tendon (sheath)

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

  • malignant neoplasm of cartilage (of):
  • articular (C40-C41)
  • larynx (C32.3)
  • nose (C30.0)
  • malignant neoplasm of connective tissue of breast (C50.-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

  • Kaposi's sarcoma of soft tissue (C46.1)
  • malignant neoplasm of heart (C38.0)
  • malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
  • malignant neoplasm of peritoneum (C48.2)
  • malignant neoplasm of retroperitoneum (C48.0)
  • malignant neoplasm of uterine ligament (C57.3)
  • mesothelioma (C45.-)

Notes

General instructions on how these codes are used.

From Chapter 2 (C00-D49) Neoplasms applies to 1,730 codes
  • Functional activity
  • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
  • Morphology [Histology]
  • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
  • Primary malignant neoplasms overlapping site boundaries
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
  • Malignant neoplasm of ectopic tissue
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name C49, its category, or a range that includes it.

Applicable To 1

These notes mention C49.

  • Z85.83 Personal history of malignant neoplasm of bone and soft tissue
    Conditions classifiable to C40-C41; C45-C49 names C45-C49, which includes this code

Excludes1 1

These codes carry an Excludes1 note naming C49: they are not reported together with it, unless the two conditions are unrelated.

  • Block C40-C41 Malignant neoplasms of bone and articular cartilage
    malignant neoplasm of synovia (C49.-)

Code First 1

These codes say to code first a condition named in the note, and C49 is one of the conditions named.

  • M63 Disorders of muscle in diseases classified elsewhere
    neoplasm (C49.-, C79.89, D21.-, D48.1-)

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Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About C49Overview

What is the ICD-10 code for malignant neoplasm of other connective and soft tissue?

C49 is the ICD-10-CM category for malignant neoplasm of other connective and soft tissue, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is C49 (Malignant neoplasm of other connective and soft tissue) a billable code?

No. This is a category header that groups the codes for malignant neoplasm of other connective and soft tissue, and headers cannot be submitted on claims. Claims for malignant neoplasm of other connective and soft tissue need a more specific code from this category, such as C49.0, C49.10, and C49.11.

Can C49 be reported with C32.3?

Not as a rule. The Excludes1 note on C49 lists "larynx (C32.3)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).