Hodgkin lymphoma (C81) ICD-10-CM
The C81 code range covers hodgkin lymphoma with 85 ICD-10-CM diagnosis codes. 77 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- personal history of Hodgkin lymphoma Z85.71
Codes in the C81 Range 85 codes · 77 billable
- C81 Hodgkin lymphomaNon-billable
- C81.0 Nodular lymphocyte predominant Hodgkin lymphomaNon-billable
- C81.00 Nodular lymphocyte predominant Hodgkin lymphoma, unspecified site
- C81.01 Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.02 Nodular lymphocyte predominant Hodgkin lymphoma, intrathoracic lymph nodes
- C81.03 Nodular lymphocyte predominant Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.04 Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.05 Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.06 Nodular lymphocyte predominant Hodgkin lymphoma, intrapelvic lymph nodes
- C81.07 Nodular lymphocyte predominant Hodgkin lymphoma, spleen
- C81.08 Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of multiple sites
- C81.09 Nodular lymphocyte predominant Hodgkin lymphoma, extranodal and solid organ sites
- C81.0A Nodular lymphocyte predominant Hodgkin lymphoma, in remission
- C81.1 Nodular sclerosis Hodgkin lymphomaNon-billable
- C81.10 Nodular sclerosis Hodgkin lymphoma, unspecified site
- C81.11 Nodular sclerosis Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.12 Nodular sclerosis Hodgkin lymphoma, intrathoracic lymph nodes
- C81.13 Nodular sclerosis Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.14 Nodular sclerosis Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.15 Nodular sclerosis Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.16 Nodular sclerosis Hodgkin lymphoma, intrapelvic lymph nodes
- C81.17 Nodular sclerosis Hodgkin lymphoma, spleen
- C81.18 Nodular sclerosis Hodgkin lymphoma, lymph nodes of multiple sites
- C81.19 Nodular sclerosis Hodgkin lymphoma, extranodal and solid organ sites
- C81.1A Nodular sclerosis Hodgkin lymphoma, in remission
- C81.2 Mixed cellularity Hodgkin lymphomaNon-billable
- C81.20 Mixed cellularity Hodgkin lymphoma, unspecified site
- C81.21 Mixed cellularity Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.22 Mixed cellularity Hodgkin lymphoma, intrathoracic lymph nodes
- C81.23 Mixed cellularity Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.24 Mixed cellularity Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.25 Mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.26 Mixed cellularity Hodgkin lymphoma, intrapelvic lymph nodes
- C81.27 Mixed cellularity Hodgkin lymphoma, spleen
- C81.28 Mixed cellularity Hodgkin lymphoma, lymph nodes of multiple sites
- C81.29 Mixed cellularity Hodgkin lymphoma, extranodal and solid organ sites
- C81.2A Mixed cellularity Hodgkin lymphoma, in remission
- C81.3 Lymphocyte depleted Hodgkin lymphomaNon-billable
- C81.30 Lymphocyte depleted Hodgkin lymphoma, unspecified site
- C81.31 Lymphocyte depleted Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.32 Lymphocyte depleted Hodgkin lymphoma, intrathoracic lymph nodes
- C81.33 Lymphocyte depleted Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.34 Lymphocyte depleted Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.35 Lymphocyte depleted Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.36 Lymphocyte depleted Hodgkin lymphoma, intrapelvic lymph nodes
- C81.37 Lymphocyte depleted Hodgkin lymphoma, spleen
- C81.38 Lymphocyte depleted Hodgkin lymphoma, lymph nodes of multiple sites
- C81.39 Lymphocyte depleted Hodgkin lymphoma, extranodal and solid organ sites
- C81.3A Lymphocyte depleted Hodgkin lymphoma, in remission
- C81.4 Lymphocyte-rich Hodgkin lymphomaNon-billable
- C81.40 Lymphocyte-rich Hodgkin lymphoma, unspecified site
- C81.41 Lymphocyte-rich Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.42 Lymphocyte-rich Hodgkin lymphoma, intrathoracic lymph nodes
- C81.43 Lymphocyte-rich Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.44 Lymphocyte-rich Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.45 Lymphocyte-rich Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.46 Lymphocyte-rich Hodgkin lymphoma, intrapelvic lymph nodes
- C81.47 Lymphocyte-rich Hodgkin lymphoma, spleen
- C81.48 Lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites
- C81.49 Lymphocyte-rich Hodgkin lymphoma, extranodal and solid organ sites
- C81.4A Lymphocyte-rich Hodgkin lymphoma, in remission
- C81.7 Other Hodgkin lymphomaNon-billable
- C81.70 Other Hodgkin lymphoma, unspecified site
- C81.71 Other Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.72 Other Hodgkin lymphoma, intrathoracic lymph nodes
- C81.73 Other Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.74 Other Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.75 Other Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.76 Other Hodgkin lymphoma, intrapelvic lymph nodes
- C81.77 Other Hodgkin lymphoma, spleen
- C81.78 Other Hodgkin lymphoma, lymph nodes of multiple sites
- C81.79 Other Hodgkin lymphoma, extranodal and solid organ sites
- C81.7A Other Hodgkin lymphoma, in remission
- C81.9 Hodgkin lymphoma, unspecifiedNon-billable
- C81.90 Hodgkin lymphoma, unspecified, unspecified site
- C81.91 Hodgkin lymphoma, unspecified, lymph nodes of head, face, and neck
- C81.92 Hodgkin lymphoma, unspecified, intrathoracic lymph nodes
- C81.93 Hodgkin lymphoma, unspecified, intra-abdominal lymph nodes
- C81.94 Hodgkin lymphoma, unspecified, lymph nodes of axilla and upper limb
- C81.95 Hodgkin lymphoma, unspecified, lymph nodes of inguinal region and lower limb
- C81.96 Hodgkin lymphoma, unspecified, intrapelvic lymph nodes
- C81.97 Hodgkin lymphoma, unspecified, spleen
- C81.98 Hodgkin lymphoma, unspecified, lymph nodes of multiple sites
- C81.99 Hodgkin lymphoma, unspecified, extranodal and solid organ sites
- C81.9A Hodgkin lymphoma, unspecified, in remission
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the C81 range.
Hodgkin Disease
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Lymphocyte-Depleted Classic Hodgkin Lymphoma
A diffuse subtype of classic Hodgkin lymphoma which is rich in Hodgkin and Reed-Sternberg cells and/or depleted in non-neoplastic lymphocytes. (WHO, 2008)
Lymphocyte-Rich Classic Hodgkin Lymphoma
A subtype of classic Hodgkin lymphoma with scattered Hodgkin and Reed-Sternberg cells and a nodular or less often diffuse cellular background consisting of small lymphocytes and with an absence of neutrophils and eosinophils. (WHO, 2008)
Mixed Cellularity Classic Hodgkin Lymphoma
A subtype of classic Hodgkin lymphoma with scattered Reed-Sternberg and Hodgkin cells in a diffuse or vaguely nodular mixed inflammatory background without nodular sclerosing fibrosis. (WHO, 2008)
Nodular Sclerosis Classic Hodgkin Lymphoma
A subtype of classic Hodgkin lymphoma characterized by collagen bands that surround at least one nodule, and Hodgkin and Reed-Sternberg cells with lacunar type morphology. (WHO, 2008)
About the C81 Code Range
Hodgkin lymphoma is a malignant disease marked by progressive enlargement of lymph nodes, the spleen, and other lymphoid tissue.
C81 first separates nodular lymphocyte predominant, nodular sclerosis, mixed cellularity, lymphocyte-depleted, and lymphocyte-rich forms. It also has categories for other Hodgkin lymphoma and Hodgkin lymphoma of unspecified type.
Each category then separates sites, including lymph nodes by body region, the spleen, multiple lymph node sites, and sites outside lymph nodes. Each also has an unspecified-site option and an in-remission option.
Questions About This Page
How many billable codes are in the C81 range?
Of the 85 codes in this range, 77 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the C81 range classify?
The range classifies hodgkin lymphoma. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
