Myelodysplastic syndromes (D46) ICD-10-CM
The D46 code range covers myelodysplastic syndromes with 13 ICD-10-CM diagnosis codes. 11 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
- drug-induced aplastic anemia D61.1
Codes in the D46 Range 13 codes · 11 billable
- D46 Myelodysplastic syndromesNon-billable
- D46.0 Refractory anemia without ring sideroblasts, so stated
- D46.1 Refractory anemia with ring sideroblasts
- D46.2 Refractory anemia with excess of blasts [RAEB]Non-billable
- D46.20 Refractory anemia with excess of blasts, unspecified
- D46.21 Refractory anemia with excess of blasts 1
- D46.22 Refractory anemia with excess of blasts 2
- D46.4 Refractory anemia, unspecified
- D46.9 Myelodysplastic syndrome, unspecified
- D46.A Refractory cytopenia with multilineage dysplasia
- D46.B Refractory cytopenia with multilineage dysplasia and ring sideroblasts
- D46.C Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality
- D46.Z Other myelodysplastic syndromes
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the D46 range.
Myelodysplastic Syndromes
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
About the D46 Code Range
ICD-10 code D46 covers a group of disorders called myelodysplastic syndromes (MDS), which involve abnormal blood cell production in the bone marrow. These codes specify different types and features of MDS used to classify the condition precisely for diagnosis and treatment planning.
The detailed codes under D46 range from refractory anemia without ring sideroblasts (D46.0) to refractory anemia with ring sideroblasts (D46.1), which is often referred to by related terms like “X chromosome-linked sideroblastic anemia.” There are also codes for refractory anemia with excess blasts (D46.2 series) describing severity levels, and other subtypes such as refractory cytopenia with multilineage dysplasia (D46.A) and MDS associated with specific chromosomal abnormalities like isolated del(5q) (D46.C). The code D46.9 denotes unspecified myelodysplastic syndrome, encompassing therapy-related and congenital forms. This classification helps medical coders select the correct ICD-10 code for the patient’s precise myelodysplastic diagnosis, ensuring clinical clarity and appropriate healthcare management.
Questions About This Page
How many billable codes are in the D46 range?
Of the 13 codes in this range, 11 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the D46 range classify?
The range classifies myelodysplastic syndromes. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
