Multiple myeloma and malignant plasma cell neoplasms (C90) ICD-10-CM
The C90 code range covers multiple myeloma and malignant plasma cell neoplasms with 17 ICD-10-CM diagnosis codes. 12 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues Z85.79
Codes in the C90 Range 17 codes · 12 billable
- C90 Multiple myeloma and malignant plasma cell neoplasmsNon-billable
- C90.0 Multiple myelomaNon-billable
- C90.00 Multiple myeloma not having achieved remission
- C90.01 Multiple myeloma in remission
- C90.02 Multiple myeloma in relapse
- C90.1 Plasma cell leukemiaNon-billable
- C90.10 Plasma cell leukemia not having achieved remission
- C90.11 Plasma cell leukemia in remission
- C90.12 Plasma cell leukemia in relapse
- C90.2 Extramedullary plasmacytomaNon-billable
- C90.20 Extramedullary plasmacytoma not having achieved remission
- C90.21 Extramedullary plasmacytoma in remission
- C90.22 Extramedullary plasmacytoma in relapse
- C90.3 Solitary plasmacytomaNon-billable
- C90.30 Solitary plasmacytoma not having achieved remission
- C90.31 Solitary plasmacytoma in remission
- C90.32 Solitary plasmacytoma in relapse
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the C90 range.
Extraosseous Plasmacytoma
A localized malignant neoplasm arising in an extraosseous site. It is composed of clonal (malignant) plasma cells forming a tumor mass. It most frequently involves the oropharynx, nasopharynx, sinuses, and larynx.
Extraosseous Plasmacytoma in Remission
A finding of extraosseous plasmacytoma that is not growing and responds to treatment.
Leukemia, Plasma Cell
A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. It can be a primary manifestation of multiple myeloma or develop as a terminal complication during the disease.
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Multiple Myeloma in Remission
A finding of plasma cell myeloma that is not growing and responds to treatment.
Plasma Cell Leukemia in Remission
A finding of plasma cell leukemia that is not growing and responds to treatment.
Plasmacytoma
Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.
Recurrent Extraosseous Plasmacytoma
The reemergence of extraosseous plasmacytoma after a period of remission.
Recurrent Plasma Cell Leukemia
The reemergence of plasma cell leukemia after a period of remission.
Recurrent Plasma Cell Myeloma
The reemergence of multiple myeloma after a period of remission.
Recurrent Solitary Plasmacytoma
The reemergence of solitary plasmacytoma after a period of remission.
Solitary Plasmacytoma in Remission
A finding of solitary plasmacytoma that is not growing and responds to treatment.
About the C90 Code Range
Multiple myeloma and other malignant plasma cell conditions belong to a larger group of cancers of lymphoid, blood-forming, and related tissue.
The categories separate C90.0 multiple myeloma, C90.1 plasma cell leukemia, C90.2 extramedullary plasmacytoma, and C90.3 solitary plasmacytoma. Each divides further by whether the condition has not achieved remission, is in remission, or is in relapse.
Questions About This Page
How many billable codes are in the C90 range?
Of the 17 codes in this range, 12 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the C90 range classify?
The range classifies multiple myeloma and malignant plasma cell neoplasms. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
