Multiple myeloma and malignant plasma cell neoplasms (C90)
The ICD-10 codes in the C90 section classify various forms of multiple myeloma and related malignant plasma cell cancers. These codes help identify specific disease states including active disease, remission, and relapse.
This section covers multiple myeloma (C90.0) and its statuses such as not having achieved remission (C90.00), remission (C90.01), and relapse (C90.02). It also includes plasma cell leukemia (C90.1) with codes distinguishing remission and relapse phases. Additionally, the codes address extramedullary plasmacytoma (C90.2) and solitary plasmacytoma (C90.3), indicating whether these tumors are in remission, relapse, or active disease. The many listed synonyms for multiple myeloma, like light chain myeloma, IgG myeloma, myeloma kidney, and AL amyloidosis, clarify coding choices for complex presentations. These codes are essential for accurately documenting patients with plasma cell neoplasms, facilitating precise communication and treatment planning. Searching for "ICD-10 code for multiple myeloma" will lead to these detailed options tailored to the patient’s current disease status.
Neoplasms (C00–D49)
Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)
C90 Multiple myeloma and malignant plasma cell neoplasms
C90.0 Multiple myeloma
- C90.00 Multiple myeloma not having achieved remission
- C90.01 Multiple myeloma in remission
- C90.02 Multiple myeloma in relapse
C90.1 Plasma cell leukemia
- C90.10 Plasma cell leukemia not having achieved remission
- C90.11 Plasma cell leukemia in remission
- C90.12 Plasma cell leukemia in relapse
C90.2 Extramedullary plasmacytoma
- C90.20 Extramedullary plasmacytoma not having achieved remission
- C90.21 Extramedullary plasmacytoma in remission
- C90.22 Extramedullary plasmacytoma in relapse
C90.3 Solitary plasmacytoma
- C90.30 Solitary plasmacytoma not having achieved remission
- C90.31 Solitary plasmacytoma in remission
- C90.32 Solitary plasmacytoma in relapse
Multiple myeloma and malignant plasma cell neoplasms (C90)
Instructional Notations
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues Z85.79
Clinical Terms
The following clinical terms provide additional context, helping users better understand the clinical background and common associations for each diagnosis listed in this section. Including related terms alongside ICD-10-CM codes supports coders, billers, and healthcare professionals in improving accuracy, enhancing documentation, and facilitating research or patient education.
Interleukin-6
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Plasmacytoma
Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.
Smoldering Multiple Myeloma
An asymptomatic and slow-growing PLASMA CELL dyscrasia characterized by presence of MYELOMA PROTEINS and clonal bone marrow plasma cells without end-organ damage (e.g., renal impairment). It is distinguished from MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE by a much higher risk of progression to symptomatic MULTIPLE MYELOMA.
