Mesothelioma (C45) ICD-10-CM
The C45 code range covers mesothelioma with 6 ICD-10-CM diagnosis codes. 5 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Codes in the C45 Range 6 codes · 5 billable
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the C45 range.
Mesothelioma
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
Pericardial Malignant Mesothelioma
A rare malignant mesothelioma that arises from the pericardium. Clinical presentation includes pericardial effusion, congestive heart failure, a mass or cardiac tamponade. Surgical resection is the treatment of choice. Adjunct treatments of chemotherapy or radiation have not improved outcomes. The prognosis is extremely poor due to its late presentation and difficulty obtaining complete surgical excision. In most cases the diagnosis is made at autopsy or postoperatively.
Peritoneal Mesothelial Neoplasm
A mesothelial neoplasm that arises from the peritoneum. It includes adenomatoid tumor, well differentiated papillary mesothelial tumor, multicystic mesothelioma, and malignant mesothelioma.
Pleural Mesothelial Neoplasm
A mesothelial neoplasm that arises from the pleura. It includes adenomatoid tumor, well differentiated papillary mesothelial tumor, and malignant mesothelioma.
About the C45 Code Range
Mesothelioma is a tumor arising from mesothelial tissue, such as tissue of the pleura, peritoneum, or pericardium.
The subdivisions distinguish mesothelioma of the pleura (C45.0), peritoneum (C45.1), and pericardium (C45.2). They also identify other sites (C45.7) and an unspecified site (C45.9).
Questions About This Page
How many billable codes are in the C45 range?
Of the 6 codes in this range, 5 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the C45 range classify?
The range classifies mesothelioma. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
