2027 ICD-10-CM Diagnosis Code E31.1Polyglandular hyperfunction
ICD-10-CM Codes›E00–E89›E20-E35›E31
- Billable — Valid for Submission
- Risk Adjusts — HCC 51
- Chronic Condition
E31.1 is a billable ICD-10-CM diagnosis code for polyglandular hyperfunction. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.
For Medicare Advantage risk adjustment, E31.1 maps to CMS-HCC Category 51 (Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders) under the V28 model, adding a risk factor of about 0.510 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E31.1 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Polyglandular hyperfunction
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E31.1: its own notes plus those printed at E31, block E20-E35, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E31.1, its category, or a range that includes it.
Code First 1
These codes say to code first a condition named in the note, and E31.1 is one of the conditions named.
- G63 Polyneuropathy in diseases classified elsewhere
Notes 1
These notes mention E31.1.
- Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseasesAll neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
polyglandular E31.1
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Endocrine Diseases
Your endocrine system includes eight major glands throughout your body. These glands make hormones. Hormones are chemical messengers. They travel through your bloodstream to tissues or organs. Hormones work slowly and affect body processes from head to toe. These include:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E31.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E31.1Overview
What is the ICD-10 code for polyglandular hyperfunction?
The ICD-10-CM code for polyglandular hyperfunction is E31.1 (sometimes written as E311). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E31.1 (Polyglandular dysfunction) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report polyglandular hyperfunction on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E31.1 group to?
When polyglandular hyperfunction is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.
Can E31.1 be reported with a code from E31.2?
Not as a rule. The Excludes1 note on E31.1 lists "multiple endocrine adenomatosis (E31.2-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of E31.1?
Under the General Equivalence Mappings, polyglandular hyperfunction converts to ICD-9-CM 258.8 (polyglandul dysfunc NEC). The mapping is approximate, so confirm the match fits the documentation.
What HCC is E31.1?
E31.1 (polyglandular hyperfunction) maps to CMS-HCC Category 51 (Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders), commonly written as HCC 51, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 23 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 43.
Does E31.1 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, E31.1 adds a risk adjustment factor of about 0.510 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.313 to 0.654 depending on the payment segment). HCC 51 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 51 category page.
