2027 ICD-10-CM Diagnosis Code E28.39Other primary ovarian failure
ICD-10-CM Codes›E00–E89›E20-E35›E28
- Billable — Valid for Submission
- Chronic Condition
E28.39 is a billable ICD-10-CM diagnosis code for other primary ovarian failure. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 742 through 743, 760 through 761. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Female infertility, Menopausal disorders, and Other specified and unspecified endocrine disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Atypical ichthyosis vulgaris with hypogonadism
- Autoimmune primary ovarian failure
- Bird-headed dwarfism with progressive ataxia, insulin-resistant diabetes, goiter, and primary gonadal insufficiency
- Boucher Neuhäuser syndrome
- Central obesity
- Colobomatous microphthalmia
- Colobomatous microphthalmia, obesity, hypogenitalism, intellectual disability syndrome
- Congenital absence of abdominal muscle
- Congenital cataract with deafness and hypogonadism syndrome
- Congenital muscular dystrophy with infantile cataract and hypogonadism syndrome
- Corpus luteum deficiency syndrome
- Cutaneous syndrome with ichthyosis
- Deafness and hypogonadism syndrome
- Decreased estrogen level
- Dilated cardiomyopathy with hypergonadotropic hypogonadism syndrome
- Female hypogonadism syndrome
- Female hypogonadotropic hypogonadism
- Female infertility due to diminished ovarian reserve
- Female infertility due to ovarian failure
- Fragile X associated primary ovarian insufficiency
- Hereditary choroidal dystrophy
- Hydrocephalus with obesity and hypogonadism syndrome
- Hypogonadal facial wrinkling
- Hypogonadal facies
- Hypogonadism
- Hypogonadism with mitral valve prolapse and intellectual disability syndrome
- Hypogonadism with prune belly syndrome
- Idiopathic premature ovarian insufficiency
- Incipient ovarian failure
- Induced female hypogonadism syndrome
- Infantile and/or juvenile cataract
- Infantile cataract
- Infantilism
- Intellectual disability, craniofacial dysmorphism, hypogonadism, diabetes mellitus syndrome
- MacDermot Winter syndrome
- MEHMO syndrome
- Menopause ovarian failure
- Nonsenile cataract
- Normogonadotropic hypogonadism
- Ovarian failure
- Ovarioleukodystrophy
- Premature ovarian insufficiency
- Premature ovarian insufficiency due to autoimmune oophoritis
- Primary hypogonadism
- Primary ovarian failure
- Progressive cerebellar ataxia
- Progressive cerebellar ataxia with hypogonadism
- Prune belly syndrome
- Resistant ovary syndrome
- Retinitis pigmentosa, intellectual disability, deafness, hypogenitalism syndrome
- Sclerosing dysplasia of bone, ichthyosis, premature ovarian failure syndrome
- Secondary ovarian failure
- Structural abnormality of abdominal wall muscle
- Syndromic X-linked intellectual disability type 7
- Vanishing white matter disease
- Woodhouse Sakati syndrome
- X-linked intellectual disability, hypogonadism, ichthyosis, obesity, short stature syndrome
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E28.39: its own notes plus those printed at E28.3, E28, block E20-E35, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Decreased estrogen
- Resistant ovary syndrome
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E28.39, its category, or a range that includes it.
Excludes1 1
These codes carry an Excludes1 note naming E28.39: they are not reported together with it, unless the two conditions are unrelated.
Code First 1
These codes say to code first a condition named in the note, and E28.39 is one of the conditions named.
- G63 Polyneuropathy in diseases classified elsewhere
Notes 1
These notes mention E28.39.
- Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseasesAll neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
estrogen E28.39
ovarian (primary) E28.39
ovary E28.39
female E28.39
ovarian (primary) E28.39
ovary E28.39
ovarian failure E28.39
Ovary, ovarian See Also: condition;
resistant syndrome E28.39
ovarian secretion E28.39
Syndrome See Also: Disease;
resistant E28.39
resistant ovary E28.39
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Primary Ovarian Failure
absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.
Patient EducationClinical
Ovarian Disorders
The ovaries are a pair of female reproductive glands that make eggs and female hormones. Women have one ovary on each side of the uterus (where a fetus grows during pregnancy). Each ovary is about the size and shape of an almond.
The full article covers:
- What are ovaries?
- What are the types of ovarian disorders?
- What causes ovarian disorders?
- What are the symptoms of ovarian disorders?
- How are ovarian disorders diagnosed?
- What are the treatments for ovarian disorders?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E28.39 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E28.39Overview
What is the ICD-10 code for other primary ovarian failure?
The ICD-10-CM code for other primary ovarian failure is E28.39 (sometimes written as E2839). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E28.39 (Primary ovarian failure) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other primary ovarian failure on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E28.39 group to?
When other primary ovarian failure is the principal diagnosis on an inpatient stay, it groups to MS-DRG 742, 743, 760, 761, with relative weights from 0.7039 to 1.8448 depending on complications. Higher weights mean higher Medicare reimbursement.
Can E28.39 be reported with Q99.1?
Not as a rule. The Excludes1 note at E28.3, which applies to E28.39, lists "pure gonadal dysgenesis (Q99.1)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of E28.39?
Under the General Equivalence Mappings, other primary ovarian failure converts to ICD-9-CM 256.39 (ovarian failure NEC). The mapping is a direct match.
