2026 ICD-10-CM Diagnosis Code E28.39Other primary ovarian failure

ICD-10-CM Codes›E00–E89›E20-E35›E28

ICD-10-CM E28.39
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E28.39 is a billable ICD-10-CM diagnosis code for other primary ovarian failure. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 742 through 743, 760 through 761. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Female infertility, Menopausal disorders, and Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E28.39
Billable Status
Yes — Valid for Submission
Code Describes
Other primary ovarian failure
Short Description
Other primary ovarian failure
Same as the full description in the CMS dataset.
Parent Code
E28.3
Primary ovarian failure

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE28Ovarian dysfunction
This CodeE28.39Other primary ovarian failure

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Atypical ichthyosis vulgaris with hypogonadism
  • Autoimmune primary ovarian failure
  • Bird-headed dwarfism with progressive ataxia, insulin-resistant diabetes, goiter, and primary gonadal insufficiency
  • Boucher Neuhäuser syndrome
  • Central obesity
  • Colobomatous microphthalmia
  • Colobomatous microphthalmia, obesity, hypogenitalism, intellectual disability syndrome
  • Congenital absence of abdominal muscle
  • Congenital cataract with deafness and hypogonadism syndrome
  • Congenital muscular dystrophy with infantile cataract and hypogonadism syndrome
  • Corpus luteum deficiency syndrome
  • Cutaneous syndrome with ichthyosis
  • Deafness and hypogonadism syndrome
  • Decreased estrogen level
  • Diabetes mellitus associated with genetic syndrome
  • Female hypogonadism syndrome
  • Female hypogonadotropic hypogonadism
  • Female infertility due to diminished ovarian reserve
  • Female infertility due to ovarian failure
  • Fragile X associated primary ovarian insufficiency
  • Hereditary choroidal dystrophy
  • Hydrocephalus with obesity and hypogonadism syndrome
  • Hypogonadal facial wrinkling
  • Hypogonadal facies
  • Hypogonadism
  • Hypogonadism with mitral valve prolapse and intellectual disability syndrome
  • Hypogonadism with prune belly syndrome
  • Idiopathic premature ovarian failure
  • Incipient ovarian failure
  • Induced female hypogonadism syndrome
  • Infantile and/or juvenile cataract
  • Infantile cataract
  • Infantilism
  • Intellectual disability, craniofacial dysmorphism, hypogonadism, diabetes mellitus syndrome
  • MacDermot Winter syndrome
  • MEHMO syndrome
  • Menopause ovarian failure
  • Nonsenile cataract
  • Ovarian failure
  • Ovarioleukodystrophy
  • Premature ovarian failure
  • Premature ovarian failure due to autoimmune oophoritis
  • Primary hypogonadism
  • Primary ovarian failure
  • Progressive cerebellar ataxia
  • Progressive cerebellar ataxia with hypogonadism
  • Prune belly syndrome
  • Resistant ovary syndrome
  • Retinitis pigmentosa, intellectual disability, deafness, hypogenitalism syndrome
  • Sclerosing dysplasia of bone, ichthyosis, premature ovarian failure syndrome
  • Secondary ovarian failure
  • Syndromic X-linked intellectual disability type 7
  • Vanishing white matter disease
  • Woodhouse Sakati syndrome
  • X-linked intellectual disability, hypogonadism, ichthyosis, obesity, short stature syndrome

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Decreased estrogen
  • Resistant ovary syndrome

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Decrease(d)
      • estrogen
    • Deficiency, deficient
      • ovarian
    • Deficiency, deficient
      • secretion
        • ovary
    • Failure, failed
      • ovarian (primary)
    • Hypofunction
      • ovary
    • Hypogonadism
      • female
    • Hypogonadism
      • ovarian (primary)
    • Hypo-ovarianism, hypo-ovarism
    • Hyposecretion
      • ovary
    • Infertility
      • female
        • due to
          • ovarian failure
    • Insufficiency, insufficient
      • gonadal
        • ovary
    • Ovary, ovarian
      • resistant syndrome
    • Suppression
      • ovarian secretion
    • Syndrome
      • ovary
        • resistant
    • Syndrome
      • resistant ovary

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR GEN024
Female infertility
Default principal diagnosis: inpatient No · outpatient No
CCSR GEN023
Menopausal disorders
Default principal diagnosis: inpatient No · outpatient No
CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Eunuchism

    the state of being a eunuch, a male without testes or whose testes failed to develop. it is characterized by the lack of mature male germ cells and testicular hormones.

  • Hypogonadism

    condition resulting from deficient gonadal functions, such as gametogenesis and the production of gonadal steroid hormones. it is characterized by delay in growth, germ cell maturation, and development of secondary sex characteristics. hypogonadism can be due to a deficiency of gonadotropins (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).

  • Kallmann Syndrome

    a genetically heterogeneous disorder caused by hypothalamic gnrh deficiency and olfactory nerve defects. it is characterized by congenital hypogonadotropic hypogonadism and anosmia, possibly with additional midline defects. it can be transmitted as an x-linked (genetic diseases, x-linked), an autosomal dominant, or an autosomal recessive trait.

  • Spinocerebellar Degenerations

    a heterogenous group of degenerative syndromes marked by progressive cerebellar dysfunction either in isolation or combined with other neurologic manifestations. sporadic and inherited subtypes occur. inheritance patterns include autosomal dominant, autosomal recessive, and x-linked.

  • Prune Belly Syndrome

    a syndrome characterized by abdominal wall musculature deficiency, cryptorchism, and urinary tract abnormalities. the syndrome derives its name from its characteristic distended abdomen with wrinkled skin.

Patient EducationClinical

Ovarian Disorders

The ovaries are a pair of female reproductive glands that make eggs and female hormones. Women have one ovary on each side of the uterus (where a fetus grows during pregnancy). Each ovary is about the size and shape of an almond.

The full article covers:

  • What are ovaries?
  • What are the types of ovarian disorders?
  • What causes ovarian disorders?
  • What are the symptoms of ovarian disorders?
  • How are ovarian disorders diagnosed?
  • What are the treatments for ovarian disorders?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E28.39 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
256.39 Ovarian failure NEC
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E28.39Overview

Is E28.39 (Primary ovarian failure) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other primary ovarian failure on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E28.39 group to?

When other primary ovarian failure is the principal diagnosis on an inpatient stay, it groups to MS-DRG 742, 743, 760, 761, with relative weights from 0.5696 to 1.8348 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E28.39?

Under the General Equivalence Mappings, other primary ovarian failure converts to ICD-9-CM 256.39 (ovarian failure NEC). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.