2027 ICD-10-CM Diagnosis Code E25.8Other adrenogenital disorders
ICD-10-CM Codes›E00–E89›E20-E35›E25
- Billable — Valid for Submission
- Chronic Condition
E25.8 is a billable ICD-10-CM diagnosis code for other adrenogenital disorders. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.
E25.8 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E25.8 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Achard-Thiers syndrome
- Disorder of androgen receptor
- Disorder of sexual differentiation
- Drug-induced adrenogenital disorder
- Female pseudopuberty
- Female puberty disorder
- Feminization-adrenogenital syndrome
- Gonadotropin independent precocious puberty
- Iatrogenic adrenogenital disorder
- Idiopathic adrenogenital disorder
- Isosexual precocious pseudopuberty
- Masculinized female
- Maternal virilization due to placental aromatase deficiency
- Precocious female puberty
- Pseudohermaphrodite, male with adrenocortical disorder
- Pseudo-puberty - feminization
- Pseudo-puberty - virilization
- Undervirilization
- Virilization of female due to SOX9 gene duplication
- Virilization of female due to SRY gene translocation
- Virilized female due to gestational hyperandrogenism
- Virilizing syndrome of adrenal origin
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E25.8: its own notes plus those printed at E25, block E20-E35, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesis
- Female adrenal pseudohermaphroditism
- Female heterosexual precocious pseudopuberty
- Male isosexual precocious pseudopuberty
- Male macrogenitosomia praecox
- Male sexual precocity with adrenal hyperplasia
- Male virilization (female)
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Idiopathic adrenogenital disorder
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Use Additional Code
Add a second code, after this one, to fully describe the condition.
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E25.8, its category, or a range that includes it.
Excludes1 4
These codes carry an Excludes1 note naming E25.8: they are not reported together with it, unless the two conditions are unrelated.
- E30.1 Precocious pubertyfemale heterosexual precocious pseudopuberty (E25.-) names E25.-, which includes this code
- E30.1 Precocious pubertymale isosexual precocious pseudopuberty (E25.-) names E25.-, which includes this code
- Q56 Indeterminate sex and pseudohermaphroditismfemale pseudohermaphroditism with adrenocortical disorder (E25.-) names E25.-, which includes this code
- Q89.1 Congenital malformations of adrenal glandadrenogenital disorders (E25.-) names E25.-, which includes this code
Code First 1
These codes say to code first a condition named in the note, and E25.8 is one of the conditions named.
- G63 Polyneuropathy in diseases classified elsewhere
Notes 1
These notes mention E25.8.
- Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseasesAll neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disorder (of) See Also: Disease;
adrenogenital See Also: Adrenogenital syndrome; E25.9
drug-induced E25.8
iatrogenic E25.8
idiopathic E25.8
adrenal E25.8
male See Also: Disorder, adrenogenital; Q56.1
adrenocortical disorder E25.8
adrenal E25.8
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Adrenal Gland Disorders
Your adrenal glands are two small organs that sit on top of each kidney. The adrenal glands make different types of hormones you need to stay alive and healthy. Hormones are chemicals that travel in your bloodstream and control how different parts of your body work.
The full article covers:
- What are adrenal glands?
- What are adrenal gland disorders?
- What causes adrenal gland disorders?
- How are adrenal gland disorders diagnosed?
- What are the treatments for adrenal gland disorders?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E25.8 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E25.8Overview
What is the ICD-10 code for other adrenogenital disorders?
The ICD-10-CM code for other adrenogenital disorders is E25.8 (sometimes written as E258). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E25.8 (Adrenogenital disorders) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other adrenogenital disorders on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E25.8 group to?
When other adrenogenital disorders is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.
Can E25.8 be reported with Q56?
Not as a rule. The Excludes1 note at E25, which applies to E25.8, lists "indeterminate sex and pseudohermaphroditism (Q56)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does E25.8 need an additional code?
When the condition applies, yes. The Use Additional Code note reads: code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5). The additional code is reported after E25.8.
Does E25.8 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. E25.8 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).
