2026 ICD-10-CM Diagnosis Code E22.1Hyperprolactinemia
ICD-10-CM Codes›E00–E89›E20-E35›E22
- Billable — Valid for Submission
- Chronic Condition
E22.1 is a billable ICD-10-CM diagnosis code for hyperprolactinemia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Pituitary disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Drug-induced hyperprolactinemia
- Familial hyperprolactinemia
- Hyperprolactinemia
- Hyperprolactinemia due to hypothyroidism
- Idiopathic hyperprolactinemia
- Lactation hyperprolactinemia
- Macroprolactinemia
- Physiological hyperprolactinemia
- Pituitary stalk compression hyperprolactinemia
- Pregnancy hyperprolactinemia
- Secondary hyperprolactinemia
- Secondary hyperprolactinemia due to prolactin-secreting tumor
- Transient hyperprolactinemia
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Hyperprolactinemia - E22.1
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Hyperprolactinemia
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Hyperprolactinemia
increased levels of prolactin in the blood, which may be associated with amenorrhea and galactorrhea. relatively common etiologies include prolactinoma, medication effect, kidney failure, granulomatous diseases of the pituitary gland, and disorders which interfere with the hypothalamic inhibition of prolactin release. ectopic (non-pituitary) production of prolactin may also occur. (from joynt, clinical neurology, 1992, ch36, pp77-8)Hyperprolactinemia
abnormally high level of prolactin in the blood.
Patient EducationClinical
Pituitary Disorders
Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E22.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E22.1Overview
Is E22.1 (Hyperfunction of pituitary gland) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report hyperprolactinemia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does E22.1 group to?
When hyperprolactinemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of E22.1?
Under the General Equivalence Mappings, hyperprolactinemia converts to ICD-9-CM 253.1 (ant pituit hyperfunc NEC). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
