2026 ICD-10-CM Diagnosis Code E22.0Acromegaly and pituitary gigantism

ICD-10-CM Codes›E00–E89›E20-E35›E22

ICD-10-CM E22.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E22.0 is a billable ICD-10-CM diagnosis code for acromegaly and pituitary gigantism. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Pituitary disorders.

Code Identity

ICD-10-CM Code
E22.0
Billable Status
Yes — Valid for Submission
Code Describes
Acromegaly and pituitary gigantism
Short Description
Acromegaly and pituitary gigantism
Same as the full description in the CMS dataset.
Parent Code
E22
Hyperfunction of pituitary gland

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE22Hyperfunction of pituitary gland
This CodeE22.0Acromegaly and pituitary gigantism

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acromegalic cardiomyopathy
  • Acromegalic facies
  • Acromegalic feet
  • Acromegaly
  • Arthropathy associated with acromegaly
  • Endocrine myopathy
  • Eunuchoid gigantism
  • Familial infantile gigantism
  • Gigantism
  • Gigantism and acromegaly
  • Gigantism due to somatostatin deficiency
  • Hyperactive behavior
  • Hypermelanosis due to acromegaly
  • Hypermelanosis due to endocrine disorder
  • Hypersomatotropic gigantism
  • Large, broad feet
  • Myopathy in acromegaly
  • Neuropathy in acromegaly
  • Overproduction of growth hormone
  • Sotos' syndrome
  • X-linked acrogigantism due to Xq26 microduplication
  • X-linked intellectual disability with acromegaly and hyperactivity syndrome

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Overproduction of growth hormone

Type 1 Excludes

  • constitutional gigantism E34.4
  • constitutional tall stature E34.4
  • increased secretion from endocrine pancreas of growth hormone-releasing hormone E16.8

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Acromegaly, acromegalia
    • Arthritis, arthritic(acute) (chronic) (nonpyogenic) (subacute)
      • due to or associated with
        • acromegaly
    • Arthritis, arthritic(acute) (chronic) (nonpyogenic) (subacute)
      • in (due to)
        • acromegaly
    • Arthropathy
      • in (due to)
        • acromegaly
    • Erdheim's syndrome(acromegalic macrospondylitis)
    • Gigantism(cerebral) (hypophyseal) (pituitary)
    • Hypersecretion
      • hormone (s)
        • growth
    • Hypophyseal, hypophysis
      • gigantism
    • Launois' syndrome(pituitary gigantism)
    • Macrospondylitis , acromegalic
    • Marie's
      • disease or syndrome (acromegaly)
    • Overproduction
      • growth hormone
    • Scaglietti-Dagnini syndrome
    • Syndrome
      • cerebral
        • gigantism
    • Syndrome
      • costovertebral
    • Syndrome
      • Erdheim's
    • Syndrome
      • Launois'
    • Syndrome
      • Marie's (acromegaly)
    • Syndrome
      • pituitary
    • Syndrome
      • Scaglietti-Dagnini

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END013
Pituitary disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Acromegaly

    a condition caused by prolonged exposure to excessive human growth hormone in adults. it is characterized by bony enlargement of the face; lower jaw (prognathism); hands; feet; head; and thorax. the most common etiology is a growth hormone-secreting pituitary adenoma. (from joynt, clinical neurology, 1992, ch36, pp79-80)

  • Growth Hormone-Secreting Pituitary Adenoma

    a pituitary tumor that secretes growth hormone. in humans, excess human growth hormone leads to acromegaly.

  • Gigantism

    the condition of accelerated and excessive growth in children or adolescents who are exposed to excess human growth hormone before the closure of epiphyses. it is usually caused by somatotroph hyperplasia or a growth hormone-secreting pituitary adenoma. these patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.

  • Sotos Syndrome

    congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. other associated features include advanced bone age, seizures, neonatal jaundice; hypotonia; and scoliosis. it is also associated with increased risk of developing neoplasms in adulthood. mutations in the nsd1 protein and its haploinsufficiency are associated with the syndrome.

Patient EducationClinical

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E22.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
253.0 Acromegaly and gigantism
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E22.0Overview

Is E22.0 (Hyperfunction of pituitary gland) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report acromegaly and pituitary gigantism on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E22.0 group to?

When acromegaly and pituitary gigantism is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E22.0?

Under the General Equivalence Mappings, acromegaly and pituitary gigantism converts to ICD-9-CM 253.0 (acromegaly and gigantism). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.