2026 ICD-10-CM Diagnosis Code D89.812Acute on chronic graft-versus-host disease

ICD-10-CM Codes›D50–D89›D80-D89›D89

ICD-10-CM D89.812
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D89.812 is a billable ICD-10-CM diagnosis code for acute on chronic graft-versus-host disease. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 808 through 810. The code is not accepted as a principal diagnosis by the Medicare Code Editor. Coders also document this condition as acute graft-versus-host disease. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Complication of transplanted organs or tissue, initial encounter; and Immunity disorders.

Code Identity

ICD-10-CM Code
D89.812
Billable Status
Yes — Valid for Submission
Code Describes
Acute on chronic graft-versus-host disease
Short Description
Acute on chronic graft-versus-host disease
Same as the full description in the CMS dataset.
Parent Code
D89.81
Graft-versus-host disease

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD80-D89Certain disorders involving the immune mechanism
CategoryD89Other disorders involving the immune mechanism, not elsewhere classified
This CodeD89.812Acute on chronic graft-versus-host disease

Code EditsBilling

Medicare Code Editor checks that affect claim validity for D89.812.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acute graft-versus-host disease
  • Acute graft-versus-host disease following transplant of kidney
  • Acute on chronic graft versus host disease following transplant of kidney
  • Acute on chronic graft-versus-host disease
  • Chronic graft-versus-host disease
  • Graft-versus-host disease following transplant of kidney

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Disease, diseased
      • graft-versus-host (GVH)
        • acute on chronic
    • Disease, diseased
      • host-versus-graft
        • acute on chronic
    • Graft-versus-host disease
      • acute on chronic

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ036
Complication of transplanted organs or tissue, initial encounter
Default principal diagnosis: inpatient No · outpatient No
CCSR BLD008
Immunity disorders
Default principal diagnosis: inpatient No · outpatient Yes

Patient EducationClinical

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

The full article covers:

  • What is the immune system?
  • What are the parts of the immune system?
  • How does the immune system work?
  • What are the types of immunity?
  • What can go wrong with the immune system?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D89.812 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
279.53 Ac on chrn grft-vs-host
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D89.812Overview

Is D89.812 (Graft-versus-host disease) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report acute on chronic graft-versus-host disease on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D89.812 group to?

On inpatient claims, acute on chronic graft-versus-host disease maps to MS-DRG 808, 809, 810, with relative weights from 1.0466 to 2.2079 depending on complications. Higher weights mean higher Medicare reimbursement.

Can D89.812 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because acute on chronic graft-versus-host disease describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

What is the ICD-9 equivalent of D89.812?

Under the General Equivalence Mappings, acute on chronic graft-versus-host disease converts to ICD-9-CM 279.53 (ac on chrn grft-vs-host). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.