2027 ICD-10-CM Diagnosis Code D89.2Hypergammaglobulinemia, unspecified

ICD-10-CM Codes›D50–D89›D80-D89›D89

ICD-10-CM D89.2
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

D89.2 is a billable ICD-10-CM diagnosis code for hypergammaglobulinemia, unspecified. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 814 through 816. Coders also document this condition as benign monoclonal gammopathy. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.

Code Identity

ICD-10-CM Code
D89.2
Billable Status
Yes — Valid for Submission
Code Describes
Hypergammaglobulinemia, unspecified
Short Description
Hypergammaglobulinemia, unspecified
Same as the full description in the CMS dataset.
Parent Code
D89
Other disorders involving the immune mechanism, not elsewhere classified

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD80-D89Certain disorders involving the immune mechanism
CategoryD89Other disorders involving the immune mechanism, not elsewhere classified
This CodeD89.2Hypergammaglobulinemia, unspecified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Benign monoclonal gammopathy
  • Benign paraproteinemia
  • Congenital hypergammaglobulinemia
  • Cryofibrinogenemia
  • Hereditary hypertrophic neuropathy with paraproteinemia
  • Mixed cryofibrinogenemia
  • Monoclonal gammopathy of uncertain significance
  • Primary cryofibrinogenemia
  • Subcorneal pustular dermatosis
  • Subcorneal pustular dermatosis with paraproteinemia

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to D89.2: its own notes plus those printed at D89, block D80-D89, and Chapter 3. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Block D80-D89 Certain disorders involving the immune mechanism applies to 83 codes
  • defects in the complement system
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
  • sarcoidosis

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From D89 Other disorders involving the immune mechanism, not elsewhere classified applies to 24 codes
  • hyperglobulinemia NOS (R77.1)
  • monoclonal gammopathy (of undetermined significance) (D47.2)
From Block D80-D89 Certain disorders involving the immune mechanism applies to 83 codes
  • autoimmune disease (systemic) NOS (M35.9)
  • functional disorders of polymorphonuclear neutrophils (D71-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From D89 Other disorders involving the immune mechanism, not elsewhere classified applies to 24 codes
  • transplant failure and rejection (T86.-)
From Block D80-D89 Certain disorders involving the immune mechanism applies to 83 codes
  • human immunodeficiency virus [HIV] disease (B20)
From Chapter 3 (D50-D89) Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism applies to 324 codes
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name D89.2, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming D89.2: they are not reported together with it, unless the two conditions are unrelated.

  • D72 Other disorders of white blood cells
    immunity disorders (D80-D89) names D80-D89, which includes this code

Excludes2 1

These codes carry an Excludes2 note naming D89.2: its condition is not part of those codes, and both may be reported when the patient has both.

  • D75 Other and unspecified diseases of blood and blood-forming organs
    hypergammaglobulinemia NOS (D89.2)

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD008
Immunity disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hypergammaglobulinemia

    an excess of gamma-globulins in the serum due to chronic infections or paraproteinemias.

Patient EducationClinical

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

The full article covers:

  • What is the immune system?
  • What are the parts of the immune system?
  • How does the immune system work?
  • What are the types of immunity?
  • What can go wrong with the immune system?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D89.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
273.1 Monoclon paraproteinemia
Approximate The match is approximate rather than exact.
ICD-9-CM
289.89 Blood diseases NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About D89.2Overview

What is the ICD-10 code for hypergammaglobulinemia, unspecified?

The ICD-10-CM code for hypergammaglobulinemia, unspecified is D89.2 (sometimes written as D892). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is D89.2 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hypergammaglobulinemia, unspecified on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does D89.2 group to?

When hypergammaglobulinemia, unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 816, 814, 815, with relative weights from 0.7378 to 2.0727 depending on complications. Higher weights mean higher Medicare reimbursement.

Can D89.2 be reported with R77.1?

Not as a rule. The Excludes1 note at D89, which applies to D89.2, lists "hyperglobulinemia NOS (R77.1)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of D89.2?

Under the General Equivalence Mappings, hypergammaglobulinemia, unspecified converts to ICD-9-CM 273.1 (monoclon paraproteinemia) and 289.89 (blood diseases NEC). The mapping is approximate, so confirm the match fits the documentation.