2027 ICD-10-CM Diagnosis Code D89.1Cryoglobulinemia
ICD-10-CM Codes›D50–D89›D80-D89›D89
- Billable — Valid for Submission
- Chronic Condition
D89.1 is a billable ICD-10-CM diagnosis code for cryoglobulinemia. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 820 through 825, 840 through 842. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.
D89.1 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 99 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D89.1 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Cryofibrinogenemia
- Cryofibrinogenemic purpura
- Cryoglobulinemia
- Cryoglobulinemia due to chronic hepatitis C
- Cryoglobulinemic glomerulonephritis
- Cryoglobulinemic purpura
- Cryoglobulinemic vasculitis
- Drug-induced necrotizing vasculitis
- Essential mixed cryoglobulinemia
- Mixed cryoimmunoglobulinemia with monoclonal component
- Mixed polyclonal cryoimmunoglobulinemia
- Monoclonal cryoimmunoglobulinemia
- Mononeuritis
- Mononeuritis multiplex
- Mononeuritis multiplex due to cryoglobulinemic vasculitis
- Necrotizing cutaneous vasculitis
- Necrotizing vasculitis due to mixed cryoglobulinemia
- Nephritis caused by drug
- Neuropathy associated with dysproteinemias
- Neuropathy in cryoglobulinemia
- Occlusion of microvasculature of skin caused by cryoglobulin type III
- Peripheral neuropathy due to inflammation
- Polyclonal gammopathy
- Primary cryoglobulinemia
- Secondary cryofibrinogenemia
- Secondary cryoglobulinemia
- Secondary cutaneous vasculitis
- Secondary systemic vasculitis
- Simple cryoglobulinemia
- Small vessel vasculitis caused by immune complex
- Vasculitic mononeuritis multiplex
- Vasculitis caused by drug
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D89.1: its own notes plus those printed at D89, block D80-D89, and Chapter 3. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Cryoglobulinemic purpura
- Cryoglobulinemic vasculitis
- Essential cryoglobulinemia
- Idiopathic cryoglobulinemia
- Mixed cryoglobulinemia
- Primary cryoglobulinemia
- Secondary cryoglobulinemia
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- transplant failure and rejection (T86.-)
- human immunodeficiency virus [HIV] disease (B20)
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D89.1, its category, or a range that includes it.
Excludes1 2
These codes carry an Excludes1 note naming D89.1: they are not reported together with it, unless the two conditions are unrelated.
Code First 3
These codes say to code first a condition named in the note, and D89.1 is one of the conditions named.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Cryoglobulinemia (essential) (idiopathic) (mixed) (primary) (purpura) (secondary) (vasculitis) D89.1
with lung involvement D89.1
Disorder (of) See Also: Disease;
Glomerulonephritis See Also: Nephritis; N05.9
cryoglobulinemia D89.1
Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) N05.9
cryoglobulinemic D89.1
Pyelonephritis See Also: Nephritis, tubulo-interstitial;
cryoglobulinemic D89.1
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Cryoglobulinemia
a condition characterized by the presence of abnormal quantities of cryoglobulins in the blood. upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.
Patient EducationClinical
Immune System and Disorders
Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.
The full article covers:
- What is the immune system?
- What are the parts of the immune system?
- How does the immune system work?
- What are the types of immunity?
- What can go wrong with the immune system?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D89.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D89.1Overview
What is the ICD-10 code for cryoglobulinemia?
The ICD-10-CM code for cryoglobulinemia is D89.1 (sometimes written as D891). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D89.1 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report cryoglobulinemia on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D89.1 group to?
When cryoglobulinemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 841, 821, 822, 825, 842, 824, 840, 820, 823, with relative weights from 0.9948 to 6.2454 depending on complications. Higher weights mean higher Medicare reimbursement.
Can D89.1 be reported with R77.1?
Not as a rule. The Excludes1 note at D89, which applies to D89.1, lists "hyperglobulinemia NOS (R77.1)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of D89.1?
Under the General Equivalence Mappings, cryoglobulinemia converts to ICD-9-CM 273.2 (paraproteinemia NEC). The mapping is a direct match.
Does D89.1 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. D89.1 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 99 (Immune Disorders).
