2026 ICD-10-CM Diagnosis Code D89.1Cryoglobulinemia

ICD-10-CM Codes›D50–D89›D80-D89›D89

ICD-10-CM D89.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D89.1 is a billable ICD-10-CM diagnosis code for cryoglobulinemia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 820 through 825, 840 through 842. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.

Code Identity

ICD-10-CM Code
D89.1
Billable Status
Yes — Valid for Submission
Code Describes
Cryoglobulinemia
Short Description
Cryoglobulinemia
Same as the full description in the CMS dataset.
Parent Code
D89
Other disorders involving the immune mechanism, not elsewhere classified

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD80-D89Certain disorders involving the immune mechanism
CategoryD89Other disorders involving the immune mechanism, not elsewhere classified
This CodeD89.1Cryoglobulinemia

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Cryofibrinogenemia
  • Cryofibrinogenemic purpura
  • Cryoglobulinemia
  • Cryoglobulinemia due to chronic hepatitis C
  • Cryoglobulinemic glomerulonephritis
  • Cryoglobulinemic purpura
  • Cryoglobulinemic vasculitis
  • Drug-induced necrotizing vasculitis
  • Essential mixed cryoglobulinemia
  • Mixed cryoimmunoglobulinemia with monoclonal component
  • Mixed polyclonal cryoimmunoglobulinemia
  • Monoclonal cryoimmunoglobulinemia
  • Mononeuritis
  • Mononeuritis multiplex
  • Mononeuritis multiplex due to cryoglobulinemic vasculitis
  • Necrotizing cutaneous vasculitis
  • Necrotizing vasculitis due to mixed cryoglobulinemia
  • Nephritis caused by drug
  • Neuropathy associated with dysproteinemias
  • Neuropathy in cryoglobulinemia
  • Occlusion of microvasculature of skin caused by cryoglobulin type III
  • Peripheral neuropathy due to inflammation
  • Polyclonal gammopathy
  • Primary cryoglobulinemia
  • Secondary cryofibrinogenemia
  • Secondary cryoglobulinemia
  • Secondary systemic vasculitis
  • Simple cryoglobulinemia
  • Small vessel vasculitis caused by immune complex
  • Vasculitic mononeuritis multiplex
  • Vasculitis caused by drug

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Cryoglobulinemic purpura
  • Cryoglobulinemic vasculitis
  • Essential cryoglobulinemia
  • Idiopathic cryoglobulinemia
  • Mixed cryoglobulinemia
  • Primary cryoglobulinemia
  • Secondary cryoglobulinemia

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Cryoglobulinemia(essential) (idiopathic) (mixed) (primary) (purpura) (secondary) (vasculitis)
    • Cryoglobulinemia(essential) (idiopathic) (mixed) (primary) (purpura) (secondary) (vasculitis)
      • with lung involvement
    • Disorder(of)
      • glomerular (in)
        • cryoglobulinemia
    • Disorder(of)
      • tubulo-interstitial (in)
        • mixed cryoglobulinemia
    • Glomerulonephritis
      • in (due to)
        • cryoglobulinemia
    • Nephritis, nephritic(albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic)
      • tubulo-interstitial (in)
        • due to
          • cryoglobulinemia
    • Purpura
      • cryoglobulinemic
    • Pyelonephritis
      • in (due to)
        • cryoglobulinemia (mixed)
    • Vasculitis
      • cryoglobulinemic

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD008
Immunity disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Cryoglobulinemia

    a condition characterized by the presence of abnormal quantities of cryoglobulins in the blood. upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.

  • Cryoglobulins

    abnormal immunoglobulins, especially igg or igm, that precipitate spontaneously when serum is cooled below 37 degrees celsius. it is characteristic of cryoglobulinemia.

  • Cryoglobulinemia

    a condition characterized by the presence of cryoglobulins in the blood. cryoglobulins are abnormal proteins that precipitate within the microvasculature on exposure to cold; microvasculature effects of cryoglobulinemia may result in restricted tissue blood flow, tissue hypoxia, and tissue necrosis. --2004

  • Cryoglobulinemic Glomerulonephritis

    glomerulonephritis in the context of cryoglobulinemia.

  • Cryoglobulinemic Glomerulonephritis Secondary to Systemic Disease

    cryoglobulinemia glomerulonephritis associated with chronic disease, often inflammatory conditions.

  • Type I Cryoglobulinemic Glomerulonephritis

    glomerulonephritis caused by cryoglobulins which are composed of monoclonal immunoglobulins igg, iga, or igm. it occurs in patients with lymphoproliferative disorders.

  • Mononeuritis Multiplex

    a painful asymmetric asynchronous sensory and motor peripheral neuropathy involving isolated damage to at least 2 separate nerve areas; associated with (but not limited to) systemic disorders such as diabetes, vasculitis, amyloidosis, direct tumor involvement, polyarteritis nodosa, rheumatoid arthritis, systemic lupus erythematosus, and paraneoplastic syndromes. it also may be associated with lyme disease, wegener's granulomatosis, sjogren syndrome, cryoglobulinemia, hypereosinophilia, temporal arteritis, scleroderma, sarcoidosis, leprosy, acute viral hepatitis a, and acquired immunodeficiency syndrome.

Patient EducationClinical

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

The full article covers:

  • What is the immune system?
  • What are the parts of the immune system?
  • How does the immune system work?
  • What are the types of immunity?
  • What can go wrong with the immune system?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D89.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
273.2 Paraproteinemia NEC
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D89.1Overview

Is D89.1 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report cryoglobulinemia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D89.1 group to?

When cryoglobulinemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 820, 821, 822, 823, 824, 825, 840, 841, 842, with relative weights from 1.0104 to 5.8648 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D89.1?

Under the General Equivalence Mappings, cryoglobulinemia converts to ICD-9-CM 273.2 (paraproteinemia NEC). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.