2026 ICD-10-CM Diagnosis Code D80.9Immunodeficiency with predominantly antibody defects, unspecified
ICD-10-CM Codes›D50–D89›D80-D89›D80
- Billable — Valid for Submission
- Chronic Condition
D80.9 is a billable ICD-10-CM diagnosis code for immunodeficiency with predominantly antibody defects, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 808 through 810. Coders also document this condition as humoral immune defect. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Humoral immune defect
- Immune defect
- Immunoglobulin subclass deficiency
- Predominant humoral immune deficiency
- Recurrent infection due to immunoglobulin isotype deficiency
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- antibody immunodeficiency - D80.9
- with
- antibody defects - D80.9
- Syndrome - See Also: Disease;
- antibody deficiency - D80.9
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Defect, defective
- antibody immunodeficiency
- Deficiency, deficient
- immunity
- humoral
- Immunodeficiency
- with
- antibody defects
- Syndrome
- antibody deficiency
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Immune System and Disorders
Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.
The full article covers:
- What is the immune system?
- What are the parts of the immune system?
- How does the immune system work?
- What are the types of immunity?
- What can go wrong with the immune system?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D80.9 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D80.9Overview
Is D80.9 (Immunodeficiency with predominantly antibody defects) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report immunodeficiency with predominantly antibody defects, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D80.9 group to?
When immunodeficiency with predominantly antibody defects, unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0466 to 2.2079 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D80.9?
Under the General Equivalence Mappings, immunodeficiency with predominantly antibody defects, unspecified converts to ICD-9-CM 279.09 (humoral immunity def NEC). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
