ICD-10-CM Code D80.1

Nonfamilial hypogammaglobulinemia

Version 2020 Billable Code

Valid for Submission

D80.1 is a billable code used to specify a medical diagnosis of nonfamilial hypogammaglobulinemia. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code D80.1 might also be used to specify conditions or terms like abnormal gamma globulin level, abnormal gamma globulin level, agammaglobulinemia, b-lymphocyte immunodeficiency, chromosome 22 abnormalities with hypogammaglobulinemia, deletion of x-chromosome and hypogammaglobulinemia, etc

Short Description:Nonfamilial hypogammaglobulinemia
Long Description:Nonfamilial hypogammaglobulinemia

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code D80.1:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Agammaglobulinemia with immunoglobulin-bearing B-lymphocytes
  • Common variable agammaglobulinemia CVAgamma
  • Hypogammaglobulinemia NOS

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code D80.1 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Abnormal gamma globulin level
  • Abnormal gamma globulin level
  • Agammaglobulinemia
  • B-lymphocyte immunodeficiency
  • Chromosome 22 abnormalities with hypogammaglobulinemia
  • Deletion of X-chromosome and hypogammaglobulinemia
  • Humoral immune defect
  • Hypogammaglobulinemia
  • Triple X syndrome, epilepsy, and hypogammaglobulinemia

Diagnostic Related Groups

The ICD-10 code D80.1 is grouped in the following groups for version MS-DRG V37.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2019 through 09/30/2020.


Convert D80.1 to ICD-9

  • 279.00 - Hypogammaglobulinem NOS

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Certain disorders involving the immune mechanism (D80-D89)
      • Immunodeficiency with predominantly antibody defects (D80)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them.

If your immune system cannot do its job, the results can be serious. Disorders of the immune system include

  • Allergy and asthma - immune responses to substances that are usually not harmful
  • Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts
  • Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake

[Learn More]