2026 ICD-10-CM Diagnosis Code E88.82Obesity due to disruption of MC4R pathway

ICD-10-CM Codes›E00–E89›E70-E88›E88

ICD-10-CM E88.82
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E88.82 is a billable ICD-10-CM diagnosis code for obesity due to disruption of MC4R pathway. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Obesity and Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E88.82
Billable Status
Yes — Valid for Submission
Code Describes
Obesity due to disruption of MC4R pathway
Short Description
Obesity due to disruption of MC4R pathway
Same as the full description in the CMS dataset.
Parent Code
E88.8
Other specified metabolic disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE88Other and unspecified metabolic disorders
This CodeE88.82Obesity due to disruption of MC4R pathway

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Use Additional Code

  • code, if applicable, to identify associated manifestations, such as polyphagia R63.2

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Obesity
      • due to
        • disruption of MC4R pathway
    • Obesity
      • due to
        • gene mutation
          • leptin (LEP)
    • Obesity
      • due to
        • gene mutation
          • leptin receptor (LEPR)
    • Obesity
      • due to
        • gene mutation
          • melanocortin 4 Receptor (MC4R)
    • Obesity
      • due to
        • gene mutation
          • nuclear receptor coactivator 1 (NCOA1)
    • Obesity
      • due to
        • gene mutation
          • proopiomelanocortin (POMC)
    • Obesity
      • due to
        • gene mutation
          • proprotein convertase subtilisin/kexin type 1 (PCSK1)
    • Obesity
      • due to
        • gene mutation
          • src homology 2B adaptor signaling protein (SH2B1)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END009
Obesity
Default principal diagnosis: inpatient No · outpatient No
CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Code History & ChangesHistory

Replacement E88.82 replaces the following previously assigned code(s):

  • E88.89 - Other specified metabolic disorders
FY 2025AddedAdded to the ICD-10-CM code setEffective October 1, 2024.
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E88.82Overview

Is E88.82 (Other specified metabolic disorders) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report obesity due to disruption of MC4R pathway on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.