2027 ICD-10-CM Diagnosis Code E88.82Obesity due to disruption of MC4R pathway

ICD-10-CM Codes›E00–E89›E70-E88›E88

ICD-10-CM E88.82
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E88.82 is a billable ICD-10-CM diagnosis code for obesity due to disruption of MC4R pathway. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 642. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Obesity and Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E88.82
Billable Status
Yes — Valid for Submission
Code Describes
Obesity due to disruption of MC4R pathway
Short Description
Obesity due to disruption of MC4R pathway
Same as the full description in the CMS dataset.
Parent Code
E88.8
Other specified metabolic disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE88Other and unspecified metabolic disorders
This CodeE88.82Obesity due to disruption of MC4R pathway

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E88.82: its own notes plus those printed at E88, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E88 Other and unspecified metabolic disorders applies to 24 codes
  • histiocytosis X (chronic) (C96.6)
From Block E70-E88 Metabolic disorders applies to 286 codes
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • Ehlers-Danlos syndromes (Q79.6-)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

On E88.82 itself
  • code, if applicable, to identify associated manifestations, such as polyphagia (R63.2)
  • code to identify body mass index (BMI), if known (Z68.-)
From E88 Other and unspecified metabolic disorders applies to 24 codes
  • codes for associated conditions

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END009
Obesity
Default principal diagnosis: inpatient No · outpatient No
CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Code History & ChangesHistory

Replacement E88.82 replaces the following previously assigned code(s):

  • E88.89 - Other specified metabolic disorders
FY 2025AddedAdded to the ICD-10-CM code setEffective October 1, 2024.
FY 2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E88.82Overview

What is the ICD-10 code for obesity due to disruption of MC4R pathway?

The ICD-10-CM code for obesity due to disruption of MC4R pathway is E88.82 (sometimes written as E8882). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E88.82 (Other specified metabolic disorders) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report obesity due to disruption of MC4R pathway on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E88.82 group to?

When obesity due to disruption of MC4R pathway is the principal diagnosis on an inpatient stay, it groups to MS-DRG 642 (inborn and Other Disorders of Metabolism), which carries a relative weight of 1.3226. Higher weights mean higher Medicare reimbursement.

Can E88.82 be reported with C96.6?

Not as a rule. The Excludes1 note at E88, which applies to E88.82, lists "histiocytosis X (chronic) (C96.6)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does E88.82 need an additional code?

When the condition applies, yes. The Use Additional Code note reads: code, if applicable, to identify associated manifestations, such as polyphagia (R63.2); code to identify body mass index (BMI), if known (Z68.-). The additional code is reported after E88.82.