2027 ICD-10-CM Diagnosis Code E88.14HIV-associated lipodystrophy

ICD-10-CM Codes›E00–E89›E70-E88›E88

ICD-10-CM E88.14
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E88.14 is a billable ICD-10-CM diagnosis code for HIV-associated lipodystrophy. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 642. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under HIV infection and Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E88.14
Billable Status
Yes — Valid for Submission
Code Describes
HIV-associated lipodystrophy
Short Description
HIV-associated lipodystrophy
Same as the full description in the CMS dataset.
Parent Code
E88.1
Lipodystrophy, not elsewhere classified

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE88Other and unspecified metabolic disorders
This CodeE88.14HIV-associated lipodystrophy

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E88.14: its own notes plus those printed at E88.1, E88, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E88.1 Lipodystrophy, not elsewhere classified applies to 6 codes
From E88 Other and unspecified metabolic disorders applies to 24 codes
  • histiocytosis X (chronic) (C96.6)
From Block E70-E88 Metabolic disorders applies to 286 codes
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • Ehlers-Danlos syndromes (Q79.6-)

Code First

The underlying condition named in the note is sequenced before this code.

  • any human immunodeficiency virus [HIV] disease (B20)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

On E88.14 itself
  • code for adverse effect, if applicable, to identify drug (T37.5X5-)
From E88 Other and unspecified metabolic disorders applies to 24 codes
  • codes for associated conditions

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INF006
HIV infection
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • HIV-Associated Lipodystrophy Syndrome

    defective metabolism leading to fat maldistribution in patients infected with hiv. the etiology appears to be multifactorial and probably involves some combination of infection-induced alterations in metabolism, direct effects of antiretroviral therapy, and patient-related factors.

Patient EducationClinical

HIV

HIV stands for human immunodeficiency virus. HIV harms your immune system by destroying a type of white blood cell that helps your body fight infection. This puts you at risk for other infections and diseases.

The full article covers:

  • What is HIV?
  • What is AIDS?
  • How does HIV spread?
  • Who is at risk for HIV infection?
  • What are the symptoms of HIV?
  • How do I know if I have HIV?
  • What are the treatments for HIV?
  • Can HIV infection be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code History & ChangesHistory

Replacement E88.14 replaces the following previously assigned code(s):

  • E88.1 - Lipodystrophy, not elsewhere classified
FY 2026AddedAdded to the ICD-10-CM code setEffective October 1, 2025.
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E88.14Overview

What is the ICD-10 code for HIV-associated lipodystrophy?

The ICD-10-CM code for HIV-associated lipodystrophy is E88.14 (sometimes written as E8814). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E88.14 (Lipodystrophy, not elsewhere classified) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report HIV-associated lipodystrophy on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E88.14 group to?

When HIV-associated lipodystrophy is the principal diagnosis on an inpatient stay, it groups to MS-DRG 642 (inborn and Other Disorders of Metabolism), which carries a relative weight of 1.3226. Higher weights mean higher Medicare reimbursement.

Can E88.14 be reported with K90.81?

Not as a rule. The Excludes1 note at E88.1, which applies to E88.14, lists "Whipple's disease (K90.81)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does E88.14 need an additional code?

When the condition applies, yes. The Use Additional Code note reads: code for adverse effect, if applicable, to identify drug (T37.5X5-). The additional code is reported after E88.14.