2027 ICD-10-CM Diagnosis Code E31.0Autoimmune polyglandular failure

ICD-10-CM Codes›E00–E89›E20-E35›E31

ICD-10-CM E31.0
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E31.0 is a billable ICD-10-CM diagnosis code for autoimmune polyglandular failure. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

For Medicare Advantage risk adjustment, E31.0 maps to CMS-HCC Category 51 (Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders) under the V28 model, adding a risk factor of about 0.510 for a community, non-dual, aged beneficiary in payment year 2027.

Code Identity

ICD-10-CM Code
E31.0
Billable Status
Yes — Valid for Submission
Code Describes
Autoimmune polyglandular failure
Short Description
Autoimmune polyglandular failure
Same as the full description in the CMS dataset.
Parent Code
E31
Polyglandular dysfunction

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE31Polyglandular dysfunction
This CodeE31.0Autoimmune polyglandular failure

Medicare Risk Adjustment (HCC)Billing

E31.0 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.

CMS-HCC V28 Category (Payment Model)
HCC 51— Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders
Payment HCC · PY 2027 one of 11 ICD-10-CM codes in this category
Risk Adjustment Factor (RAF) Weight
+0.510
community, non-dual, aged · ranges 0.313–0.654 across segments
Hierarchy
Top of its hierarchy
HCC 51 is not superseded by any other condition category
Prior Model (CMS-HCC V24)
HCC 23
V24 retired V28 pays 100% of MA risk scores since PY 2026
Other CMS Models
PACE (CMS-HCC V22): HCC 23 · ESRD (V21): HCC 23 · ESRD (V24): HCC 23
ESRD V21 weights: 0.013 dialysis, 0.234–0.359 functioning graft · ESRD V24 weights: 0.036 dialysis, 0.217–0.390 functioning graft
Part D (RxHCC)
RxHCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • A. Schmidt's syndrome
  • Addison's disease
  • Autoimmune enteropathy
  • Autoimmune enteropathy and endocrinopathy with susceptibility to chronic infection syndrome
  • Autoimmune hypoparathyroidism
  • Autoimmune polyendocrine syndrome type 3
  • Autoimmune polyendocrine syndrome type 4
  • Autoimmune polyendocrinopathy
  • Multiple cranial nerve palsy
  • Polyglandular autoimmune syndrome, type 1
  • Polyglandular autoimmune syndrome, type 2

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E31.0: its own notes plus those printed at E31, block E20-E35, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Schmidt's syndrome

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E31 Polyglandular dysfunction applies to 8 codes
  • ataxia telangiectasia [Louis-Bar] (G11.3)
  • dystrophia myotonica [Steinert] (G71.11)
  • pseudohypoparathyroidism (E20.1)
From Block E20-E35 Disorders of other endocrine glands applies to 99 codes
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E31.0, its category, or a range that includes it.

Code First 3

These codes say to code first a condition named in the note, and E31.0 is one of the conditions named.

  • E20.812 Autoimmune hypoparathyroidism
    autoimmune polyglandular failure (E31.0)
  • E20.812 Autoimmune hypoparathyroidism
    Schmidt's syndrome (E31.0)
  • G63 Polyneuropathy in diseases classified elsewhere
    endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34) names E20-E34, which includes this code

Notes 1

These notes mention E31.0.

  • Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases
    All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Autoimmune Diseases

Your immune system protects you from disease and infection by attacking germs that get into your body, such as viruses and bacteria. Your immune system can tell that the germs aren't part of you, so it destroys them. If you have an autoimmune disease, your immune system attacks the healthy cells of your organs and tissues by mistake.

The full article covers:

  • What are autoimmune diseases?
  • What causes autoimmune diseases?
  • Who is at risk for autoimmune diseases?
  • What are the symptoms of autoimmune diseases?
  • How are autoimmune diseases diagnosed?
  • What are the treatments for autoimmune diseases?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E31.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
258.1 Comb endocr dysfunct NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E31.0Overview

What is the ICD-10 code for autoimmune polyglandular failure?

The ICD-10-CM code for autoimmune polyglandular failure is E31.0 (sometimes written as E310). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E31.0 (Polyglandular dysfunction) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report autoimmune polyglandular failure on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E31.0 group to?

When autoimmune polyglandular failure is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.

Can E31.0 be reported with G11.3?

Not as a rule. The Excludes1 note at E31, which applies to E31.0, lists "ataxia telangiectasia [Louis-Bar] (G11.3)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of E31.0?

Under the General Equivalence Mappings, autoimmune polyglandular failure converts to ICD-9-CM 258.1 (comb endocr dysfunct NEC). The mapping is approximate, so confirm the match fits the documentation.

What HCC is E31.0?

E31.0 (autoimmune polyglandular failure) maps to CMS-HCC Category 51 (Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders), commonly written as HCC 51, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 23 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 43.

Does E31.0 risk-adjust for Medicare Advantage payment?

Yes. When documented and reported on a Medicare Advantage encounter, E31.0 adds a risk adjustment factor of about 0.510 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.313 to 0.654 depending on the payment segment). HCC 51 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 51 category page.