2026 ICD-10-CM Diagnosis Code E31.0Autoimmune polyglandular failure

ICD-10-CM Codes›E00–E89›E20-E35›E31

ICD-10-CM E31.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E31.0 is a billable ICD-10-CM diagnosis code for autoimmune polyglandular failure. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E31.0
Billable Status
Yes — Valid for Submission
Code Describes
Autoimmune polyglandular failure
Short Description
Autoimmune polyglandular failure
Same as the full description in the CMS dataset.
Parent Code
E31
Polyglandular dysfunction

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE31Polyglandular dysfunction
This CodeE31.0Autoimmune polyglandular failure

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • A. Schmidt's syndrome
  • Addison's disease
  • Autoimmune enteropathy
  • Autoimmune enteropathy and endocrinopathy with susceptibility to chronic infection syndrome
  • Autoimmune hypoparathyroidism
  • Autoimmune polyendocrine syndrome type 3
  • Autoimmune polyendocrine syndrome type 4
  • Autoimmune polyendocrinopathy
  • Multiple cranial nerve palsy
  • Polyglandular autoimmune syndrome, type 1
  • Polyglandular autoimmune syndrome, type 2

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Schmidt's syndrome

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Atrophy, atrophic(of)
      • pluriglandular
        • autoimmune
    • Deficiency, deficient
      • polyglandular
        • autoimmune
    • Failure, failed
      • polyglandular, autoimmune
    • Insufficiency, insufficient
      • progressive pluriglandular
    • Polyglandular
      • deficiency
    • Schmidt's syndrome(polyglandular, autoimmune)
    • Syndrome
      • autoimmune polyglandular
    • Syndrome
      • pluriglandular (compensatory)
        • autoimmune
    • Syndrome
      • polyglandular
        • autoimmune
    • Syndrome
      • thyroid-adrenocortical insufficiency

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Chronic Mucocutaneous Candidiasis

    mucocutaneous candidiasis that is persistent or long-standing in nature.

Patient EducationClinical

Autoimmune Diseases

Your immune system protects you from disease and infection by attacking germs that get into your body, such as viruses and bacteria. Your immune system can tell that the germs aren't part of you, so it destroys them. If you have an autoimmune disease, your immune system attacks the healthy cells of your organs and tissues by mistake.

The full article covers:

  • What are autoimmune diseases?
  • What causes autoimmune diseases?
  • Who is at risk for autoimmune diseases?
  • What are the symptoms of autoimmune diseases?
  • How are autoimmune diseases diagnosed?
  • What are the treatments for autoimmune diseases?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E31.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
258.1 Comb endocr dysfunct NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E31.0Overview

Is E31.0 (Polyglandular dysfunction) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report autoimmune polyglandular failure on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E31.0 group to?

When autoimmune polyglandular failure is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E31.0?

Under the General Equivalence Mappings, autoimmune polyglandular failure converts to ICD-9-CM 258.1 (comb endocr dysfunct NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.