2027 ICD-10-CM Diagnosis Code E28.310Symptomatic premature menopause

ICD-10-CM Codes›E00–E89›E20-E35›E28

ICD-10-CM E28.310
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E28.310 is a billable ICD-10-CM diagnosis code for symptomatic premature menopause. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 742 through 743, 760 through 761. The code is restricted by the Medicare Code Editor to adult patients (age 15 through 124). Coders also document this condition as menopausal syndrome. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Female infertility, Menopausal disorders, and Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E28.310
Billable Status
Yes — Valid for Submission
Code Describes
Symptomatic premature menopause
Short Description
Symptomatic premature menopause
Same as the full description in the CMS dataset.
Parent Code
E28.31
Premature menopause

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE28Ovarian dysfunction
This CodeE28.310Symptomatic premature menopause

Code EditsBilling

Medicare Code Editor checks that affect claim validity for E28.310.

Adult diagnoses
The Medicare Code Editor detects inconsistencies in adult cases by checking a patient's age and any diagnosis on the patient's record. The adult code edits apply to patients age range is 15–124 years inclusive (e.g., senile delirium, mature cataract).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Menopausal syndrome
  • Menopause caused by ionizing radiation
  • Postartificial menopausal syndrome

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E28.310: its own notes plus those printed at E28.3, E28, block E20-E35, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with premature menopause

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E28.3 Primary ovarian failure applies to 3 codes
  • pure gonadal dysgenesis (Q99.1)
  • Turner's syndrome (Q96.-)
From E28 Ovarian dysfunction applies to 8 codes
  • isolated gonadotropin deficiency (E23.0)
  • postprocedural ovarian failure (E89.4-)
From Block E20-E35 Disorders of other endocrine glands applies to 99 codes
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E28.310, its category, or a range that includes it.

Excludes1 4

These codes carry an Excludes1 note naming E28.310: they are not reported together with it, unless the two conditions are unrelated.

  • N95.1 Menopausal and female climacteric states
    symptoms associated with premature menopause (E28.310)
  • N91 Absent, scanty and rare menstruation
    ovarian dysfunction (E28.-) names E28.-, which includes this code
  • N95 Menopausal and other perimenopausal disorders
    menopausal and perimenopausal disorders due to artificial or premature menopause (E89.4-, E28.31-) names E28.31-, which includes this code
  • N95 Menopausal and other perimenopausal disorders
    premature menopause (E28.31-) names E28.31-, which includes this code

Code First 1

These codes say to code first a condition named in the note, and E28.310 is one of the conditions named.

  • G63 Polyneuropathy in diseases classified elsewhere
    endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34) names E20-E34, which includes this code

Code Also 1

These codes say E28.310 may also be needed to fully describe the condition. The note gives no sequencing direction.

  • Z91.B Personal risk factor of exposure to diethylstilbestrol
    premature menopause (E28.31-) names E28.31-, which includes this code

Notes 1

These notes mention E28.310.

  • Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases
    All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR GEN024
Female infertility
Default principal diagnosis: inpatient No · outpatient No
CCSR GEN023
Menopausal disorders
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • Menopause, Premature

    the premature cessation of menses (menstruation) when the last menstrual period occurs in a woman under the age of 40. it is due to the depletion of ovarian follicles. premature menopause can be caused by diseases; ovariectomy; radiation; chemicals; and chromosomal abnormalities.

Patient EducationClinical

Menopause

Menopause is the time in your life when you stop having your period and can no longer get pregnant. You have reached menopause when you have not had a period for 12 months.

The full article covers:

  • What is menopause?
  • What is early and premature menopause?
  • What are the symptoms of menopause?
  • What are the treatments for the symptoms of menopause?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E28.310 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
256.31 Premature menopause
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E28.310Overview

What is the ICD-10 code for symptomatic premature menopause?

The ICD-10-CM code for symptomatic premature menopause is E28.310 (sometimes written as E28310). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E28.310 (Premature menopause) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report symptomatic premature menopause on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E28.310 group to?

When symptomatic premature menopause is the principal diagnosis on an inpatient stay, it groups to MS-DRG 742, 743, 760, 761, with relative weights from 0.7039 to 1.8448 depending on complications. Higher weights mean higher Medicare reimbursement.

Who can E28.310 be reported for?

The Medicare Code Editor checks symptomatic premature menopause against patient demographics: this code is intended for adult patients (age 15 through 124). Claims outside these limits are flagged as inconsistent.

Can E28.310 be reported with Q99.1?

Not as a rule. The Excludes1 note at E28.3, which applies to E28.310, lists "pure gonadal dysgenesis (Q99.1)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).