2026 ICD-10-CM Diagnosis Code E28.310Symptomatic premature menopause

ICD-10-CM Codes›E00–E89›E20-E35›E28

ICD-10-CM E28.310
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E28.310 is a billable ICD-10-CM diagnosis code for symptomatic premature menopause. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 742 through 743, 760 through 761. The code is restricted by the Medicare Code Editor to adult patients (age 15 through 124). Coders also document this condition as menopausal syndrome. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Female infertility, Menopausal disorders, and Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E28.310
Billable Status
Yes — Valid for Submission
Code Describes
Symptomatic premature menopause
Short Description
Symptomatic premature menopause
Same as the full description in the CMS dataset.
Parent Code
E28.31
Premature menopause

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE28Ovarian dysfunction
This CodeE28.310Symptomatic premature menopause

Code EditsBilling

Medicare Code Editor checks that affect claim validity for E28.310.

Adult diagnoses
The Medicare Code Editor detects inconsistencies in adult cases by checking a patient's age and any diagnosis on the patient's record. The adult code edits apply to patients age range is 15–124 years inclusive (e.g., senile delirium, mature cataract).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Menopausal syndrome
  • Menopause caused by ionizing radiation
  • Postartificial menopausal syndrome

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with premature menopause

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Menopause, menopausal(asymptomatic) (state)
      • premature
        • symptomatic
    • Premature
      • menopause
        • symptomatic

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR GEN024
Female infertility
Default principal diagnosis: inpatient No · outpatient No
CCSR GEN023
Menopausal disorders
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • Menopausal Syndrome

    a grouping of variable physical, vasomotor and psychological symptoms in climacteric females. physical symptoms include: cessation of menses, headaches, fatigue, weight gain and vaginal dryness. vasomotor symptoms typically include: palpitations, hot flashes and night sweats. psychological symptoms may include: decrease in libido, emotional lability, difficulty concentrating and insomnia.

Patient EducationClinical

Menopause

Menopause is the time in your life when you stop having your period and can no longer get pregnant. You have reached menopause when you have not had a period for 12 months.

The full article covers:

  • What is menopause?
  • What is early menopause?
  • What are the symptoms of menopause?
  • What are the treatments for the symptoms of menopause?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E28.310 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
256.31 Premature menopause
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E28.310Overview

Is E28.310 (Premature menopause) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report symptomatic premature menopause on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E28.310 group to?

When symptomatic premature menopause is the principal diagnosis on an inpatient stay, it groups to MS-DRG 742, 743, 760, 761, with relative weights from 0.5696 to 1.8348 depending on complications. Higher weights mean higher Medicare reimbursement.

Who can E28.310 be reported for?

The Medicare Code Editor checks symptomatic premature menopause against patient demographics: this code is intended for adult patients (age 15 through 124). Claims outside these limits are flagged as inconsistent.

What is the ICD-9 equivalent of E28.310?

Under the General Equivalence Mappings, symptomatic premature menopause converts to ICD-9-CM 256.31 (premature menopause). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.