2026 ICD-10-CM Diagnosis Code E23.2Diabetes insipidus

ICD-10-CM Codes›E00–E89›E20-E35›E23

ICD-10-CM E23.2
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E23.2 is a billable ICD-10-CM diagnosis code for diabetes insipidus. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Pituitary disorders.

Code Identity

ICD-10-CM Code
E23.2
Billable Status
Yes — Valid for Submission
Code Describes
Diabetes insipidus
Short Description
Diabetes insipidus
Same as the full description in the CMS dataset.
Parent Code
E23
Hypofunction and other disorders of the pituitary gland

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE23Hypofunction and other disorders of the pituitary gland
This CodeE23.2Diabetes insipidus

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Adipsic vasopressin-related polyuria
  • Autosomal dominant hereditary vasopressin deficiency
  • Autosomal recessive hereditary arginine vasopressin deficiency
  • Bilateral optic atrophy of eyes
  • Delayed onset arginine vasopressin deficiency due to and following traumatic brain injury
  • Excessive thirst
  • Familial vasopressin deficiency
  • Familial vasopressin-related polyuria
  • Hereditary vasopressin-related polyuria
  • Hypohidrosis
  • Hypohidrosis-diabetes insipidus syndrome
  • Idiopathic vasopressin-related polyuria
  • Late effect of traumatic injury to brain
  • Leber's amaurosis
  • Paresis of left lower limb
  • Paresis of right lower limb
  • Partial vasopressin-related polyuria
  • Postoperative vasopressin deficiency
  • Primary polydipsia
  • Secondary vasopressin deficiency
  • Secondary vasopressin-related polyuria
  • Spastic tetraparesis
  • Tetraparesis
  • Vasopressin deficiency
  • Vasopressin deficiency due to trauma
  • Vasopressin-related polyuria
  • Weakness of bilateral lower limb
  • Weakness of left lower limb
  • Weakness of left upper limb
  • Weakness of right lower limb
  • Weakness of right upper limb
  • Wolfram syndrome
  • Wolfram syndrome type 1
  • Wolfram syndrome type 2
  • X-linked intellectual disability, limb spasticity, retinal dystrophy, arginine vasopressin deficiency

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • nephrogenic diabetes insipidus N25.1

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Deficiency, deficient
      • antidiuretic hormone
    • Deficiency, deficient
      • vasopressin
    • Diabetes, diabetic(mellitus) (sugar)
      • insipidus
    • Diabetes, diabetic(mellitus) (sugar)
      • insipidus
        • pituitary
    • Hyposecretion
      • antidiuretic hormone
    • Hyposecretion
      • vasopressin
    • Inappropriate
      • secretion
        • antidiuretic hormone (ADH) (excessive)
          • deficiency
    • Perversion, perverted
      • function
        • pituitary gland

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END013
Pituitary disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Diabetes Insipidus

    a disease that is characterized by frequent urination, excretion of large amounts of dilute urine, and excessive thirst. etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as adh or vasopressin) secreted by the neurohypophysis, impaired kidney response to adh, and impaired hypothalamic regulation of thirst.

  • Diabetes Insipidus, Nephrogenic

    a genetic or acquired polyuric disorder characterized by persistent hypotonic urine and hypokalemia. this condition is due to renal tubular insensitivity to vasopressin and failure to reduce urine volume. it may be the result of mutations of genes encoding vasopressin receptors or aquaporin-2; kidney diseases; adverse drug effects; or complications from pregnancy.

  • Diabetes Insipidus, Neurogenic

    a genetic or acquired polyuric disorder caused by a deficiency of vasopressins secreted by the neurohypophysis. clinical signs include the excretion of large volumes of dilute urine; hypernatremia; thirst; and polydipsia. etiologies include head trauma; surgeries and diseases involving the hypothalamus and the pituitary gland. this disorder may also be caused by mutations of genes such as arvp encoding vasopressin and its corresponding neurophysin (neurophysins).

  • Wolfram Syndrome

    a hereditary condition characterized by multiple symptoms including those of diabetes insipidus; diabetes mellitus; optic atrophy; and deafness. this syndrome is also known as didmoad (first letter of each word) and is usually associated with vasopressin deficiency. it is caused by mutations in gene wfs1 encoding wolframin, a 100-kda transmembrane protein.

  • Hypohidrosis

    abnormally diminished or absent perspiration. both generalized and segmented (reduced or absent sweating in circumscribed locations) forms of the disease are usually associated with other underlying conditions.

  • Adipsic Diabetes Insipidus

    diabetes insipidus complicated by a deficient or absent thirst response to hyperosmolality, usually as a result of hypothalamic damage or dysfunction.

  • Autosomal Dominant Neurohypophyseal Diabetes Insipidus|ADNDI

    an autosomal dominant form of diabetes insipidus caused by mutation(s) in the avp gene encoding arginine vasopressin.

  • AVP wt Allele|ADH|ARVP|AVP|AVP-NPII|AVRP|Arginine Vasopressin (Neurophysin II, Antidiuretic Hormone, Diabetes Insipidus, Neurohypophyseal) Gene|Arginine Vasopressin wt Allele|VP

    human avp wild-type allele is located in the vicinity of 20p13 and is approximately 3 kb in length. this allele, which encodes vasopressin-neurophysin 2-copeptin protein, is involved in the mediation of a wide variety of bodily functions. mutations in the gene results in autosomal dominant neurohypophyseal diabetes insipidus.

  • AVPR2 wt Allele|ADHR|Arginine Vasopressin Receptor 2 (Nephrogenic Diabetes Insipidus) Gene|Arginine Vasopressin Receptor 2 wt Allele|DI1|DIR|DIR3|NDI|V2R

    human avpr2 wild-type allele is located within xq28 and is approximately 5 kb in length. this allele, which encodes vasopressin v2 receptor protein, is involved in the maintenance of water homeostasis and g protein-coupled receptor signal transduction. when the function of the gene is absent, it results in nephrogenic diabetes insipidus (ndi).

  • Diabetes Insipidus

    a disorder characterized by excretion of large amounts of urine, accompanied by excessive thirst. causes include deficiency of antidiuretic hormone or failure of the kidneys to respond to antidiuretic hormone. it may also be drug-related.

  • Dipsogenic Diabetes Insipidus|Primary Polydipsia

    diabetes insipidus caused by excessive intake of water due to psychological factors or damage to the thirst-regulating mechanism.

  • Nephrogenic Diabetes Insipidus

    diabetes insipidus caused by insensitivity of the kidneys to antidiuretic hormone.

  • Neurogenic Diabetes Insipidus|ADH Deficiency|AVP deficiency|Antidiuretic Hormone Deficiency|Arginine Vasopressin Deficiency|Central Diabetes Insipidus|Vasopressin Deficiency

    diabetes insipidus caused by decreased secretion of antidiuretic hormone from the pituitary gland.

  • Wolfram Syndrome|DIDMOAD|DIDMOAD|Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness Syndrome

    a rare inherited syndrome caused by mutations in the wfs1 and cisd2 genes. it is characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness.

  • Grade 2 Hypohidrosis, CTCAE|Grade 2 Hypohidrosis

    symptomatic; limiting instrumental adl

  • Grade 3 Hypohidrosis, CTCAE|Grade 3 Hypohidrosis

    increase in body temperature; limiting self care adl

  • Grade 4 Hypohidrosis, CTCAE|Grade 4 Hypohidrosis

    heat stroke

  • Grade 5 Hypohidrosis, CTCAE|Grade 5 Hypohidrosis

    death

  • Hypohidrosis

    reduced sweating. causes include burns, dehydration, radiation, and leprosy.

  • Hypohidrosis, CTCAE|Hypohidrosis|Hypohidrosis

    a disorder characterized by reduced sweating.

  • Grade 2 Hypohidrosis, CTCAE|Grade 2 Hypohidrosis

    symptomatic; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

  • Grade 3 Hypohidrosis, CTCAE|Grade 3 Hypohidrosis

    increase in body temperature; limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

  • Grade 4 Hypohidrosis, CTCAE|Grade 4 Hypohidrosis

    life-threatening consequences; urgent intervention indicated

Patient EducationClinical

Diabetes Insipidus

Diabetes insipidus (DI) causes frequent urination. You become extremely thirsty, so you drink. Then you urinate. This cycle can keep you from sleeping or even make you wet the bed. Your body produces lots of urine that is almost all water.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E23.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
253.5 Diabetes insipidus
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E23.2Overview

Is E23.2 (Hypofunction and other disorders of the pituitary gland) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report diabetes insipidus on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E23.2 group to?

When diabetes insipidus is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E23.2?

Under the General Equivalence Mappings, diabetes insipidus converts to ICD-9-CM 253.5 (diabetes insipidus). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.