2027 ICD-10-CM Diagnosis Code E23.2Diabetes insipidus
ICD-10-CM Codes›E00–E89›E20-E35›E23
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Chronic Condition
E23.2 is a billable ICD-10-CM diagnosis code for diabetes insipidus. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645, 791, 793. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 19 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Pituitary disorders.
E23.2 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E23.2 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Adipsic vasopressin-related polyuria
- Autosomal dominant hereditary vasopressin deficiency
- Autosomal recessive hereditary arginine vasopressin deficiency
- Bilateral optic atrophy of eyes
- Delayed onset arginine vasopressin deficiency due to and following traumatic brain injury
- Excessive thirst
- Familial vasopressin deficiency
- Familial vasopressin-related polyuria
- Hereditary vasopressin-related polyuria
- Hypohidrosis
- Hypohidrosis-diabetes insipidus syndrome
- Idiopathic vasopressin-related polyuria
- Late effect of traumatic injury to brain
- Leber's amaurosis
- Paresis of left lower limb
- Paresis of right lower limb
- Partial vasopressin-related polyuria
- Postoperative vasopressin deficiency
- Primary polydipsia
- Secondary vasopressin deficiency
- Secondary vasopressin-related polyuria
- Spastic tetraparesis
- Tetraparesis
- Vasopressin deficiency
- Vasopressin deficiency due to trauma
- Vasopressin-related polyuria
- Weakness of bilateral lower limb
- Weakness of left lower limb
- Weakness of left upper limb
- Weakness of right lower limb
- Weakness of right upper limb
- Wolfram syndrome
- Wolfram syndrome type 1
- Wolfram syndrome type 2
- X-linked intellectual disability, limb spasticity, retinal dystrophy, arginine vasopressin deficiency
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E23.2: its own notes plus those printed at E23, block E20-E35, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- the listed conditions whether the disorder is in the pituitary or the hypothalamus
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- nephrogenic diabetes insipidus (N25.1)
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E23.2, its category, or a range that includes it.
Excludes1 2
These codes carry an Excludes1 note naming E23.2: they are not reported together with it, unless the two conditions are unrelated.
Code First 1
These codes say to code first a condition named in the note, and E23.2 is one of the conditions named.
- G63 Polyneuropathy in diseases classified elsewhere
Notes 1
These notes mention E23.2.
- Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseasesAll neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
antidiuretic hormone E23.2
vasopressin E23.2
antidiuretic hormone E23.2
vasopressin E23.2
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Diabetes Insipidus
a disease that is characterized by frequent urination, excretion of large amounts of dilute urine, and excessive thirst. etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as adh or vasopressin) secreted by the neurohypophysis, impaired kidney response to adh, and impaired hypothalamic regulation of thirst.
Patient EducationClinical
Diabetes Insipidus
Diabetes insipidus (DI) causes frequent urination. You become extremely thirsty, so you drink. Then you urinate. This cycle can keep you from sleeping or even make you wet the bed. Your body produces lots of urine that is almost all water.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E23.2 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E23.2Overview
What is the ICD-10 code for diabetes insipidus?
The ICD-10-CM code for diabetes insipidus is E23.2 (sometimes written as E232). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E23.2 (Hypofunction and other disorders of the pituitary gland) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report diabetes insipidus on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E23.2 group to?
When diabetes insipidus is the principal diagnosis on an inpatient stay, it groups to MS-DRG 793, 791, 644, 645, 643, with relative weights from 0.7461 to 4.2192 depending on complications. Higher weights mean higher Medicare reimbursement.
Is E23.2 a CC or MCC?
CMS lists E23.2 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 19 closely related codes in its exclusion list.
Can E23.2 be reported with N25.1?
Not as a rule. The Excludes1 note on E23.2 lists "nephrogenic diabetes insipidus (N25.1)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does E23.2 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. E23.2 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).
