2026 ICD-10-CM Diagnosis Code E22.9Hyperfunction of pituitary gland, unspecified

ICD-10-CM Codes›E00–E89›E20-E35›E22

ICD-10-CM E22.9
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E22.9 is a billable ICD-10-CM diagnosis code for hyperfunction of pituitary gland, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. Coders also document this condition as hyperpituitarism. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Pituitary disorders.

Code Identity

ICD-10-CM Code
E22.9
Billable Status
Yes — Valid for Submission
Code Describes
Hyperfunction of pituitary gland, unspecified
Short Description
Hyperfunction of pituitary gland, unspecified
Same as the full description in the CMS dataset.
Parent Code
E22
Hyperfunction of pituitary gland

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE22Hyperfunction of pituitary gland
This CodeE22.9Hyperfunction of pituitary gland, unspecified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Hyperpituitarism

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Hyperfunction
      • pituitary (gland) (anterior)
    • Hyperpituitarism
    • Hypersecretion
      • hormone (s)
        • pituitary
    • Increase, increased
      • function
        • pituitary (gland) (anterior) (lobe)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END013
Pituitary disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hyperpituitarism

    disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. hyperpituitarism usually is caused by a functional adenoma.

Patient EducationClinical

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E22.9 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
253.1 Ant pituit hyperfunc NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E22.9Overview

Is E22.9 (Hyperfunction of pituitary gland) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hyperfunction of pituitary gland, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E22.9 group to?

When hyperfunction of pituitary gland, unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E22.9?

Under the General Equivalence Mappings, hyperfunction of pituitary gland, unspecified converts to ICD-9-CM 253.1 (ant pituit hyperfunc NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.