2026 ICD-10-CM Diagnosis Code D59.2Drug-induced nonautoimmune hemolytic anemia

ICD-10-CM Codes›D50–D89›D55-D59›D59

ICD-10-CM D59.2
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D59.2 is a billable ICD-10-CM diagnosis code for drug-induced nonautoimmune hemolytic anemia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 808 through 810. Coders also document this condition as drug-induced non autoimmune hemolytic anemia. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Hemolytic anemia.

Code Identity

ICD-10-CM Code
D59.2
Billable Status
Yes — Valid for Submission
Code Describes
Drug-induced nonautoimmune hemolytic anemia
Short Description
Drug-induced nonautoimmune hemolytic anemia
Same as the full description in the CMS dataset.
Parent Code
D59
Acquired hemolytic anemia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD59Acquired hemolytic anemia
This CodeD59.2Drug-induced nonautoimmune hemolytic anemia

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Drug-induced non autoimmune hemolytic anemia
  • Hemolytic anemia caused by drugs
  • Non-autoimmune hemolytic anemia
  • Primaquine sensitivity anemia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Drug-induced enzyme deficiency anemia

Use Additional Code

  • code for adverse effect, if applicable, to identify drug T36 T50

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • deficiency
        • enzyme
          • drug-induced (hemolytic)
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • enzyme-deficiency, drug-induced
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • due to
          • drugs (nonautoimmune)
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • due to
          • enzyme disorder
            • drug-induced
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • nonautoimmune
          • drug-induced
    • Disease, diseased
      • nonautoimmune hemolytic
        • drug-induced
    • Nonautoimmune hemolytic anemia
      • drug-induced

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR BLD002
Hemolytic anemia
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • Acquired Hemolytic Anemia

    hemolytic anemia, the cause of which is not present at birth.

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D59.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
283.19 Oth nonauto hem anemia
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D59.2Overview

Is D59.2 (Acquired hemolytic anemia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report drug-induced nonautoimmune hemolytic anemia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D59.2 group to?

When drug-induced nonautoimmune hemolytic anemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0466 to 2.2079 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D59.2?

Under the General Equivalence Mappings, drug-induced nonautoimmune hemolytic anemia converts to ICD-9-CM 283.19 (oth nonauto hem anemia). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.