2027 ICD-10-CM Diagnosis Code D59.2Drug-induced nonautoimmune hemolytic anemia
ICD-10-CM Codes›D50–D89›D55-D59›D59
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Not Chronic
D59.2 is a billable ICD-10-CM diagnosis code for drug-induced nonautoimmune hemolytic anemia. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 791, 793, 808 through 810. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 112 closely related codes. Coders also document this condition as drug-induced non autoimmune hemolytic anemia. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Hemolytic anemia.
D59.2 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 46 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 46, ESRD (V21) category 46, ESRD (V24) category 46, and RxHCC Part D (V08) category 96 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D59.2 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Drug-induced non autoimmune hemolytic anemia
- Hemolytic anemia caused by drugs
- Non-autoimmune hemolytic anemia
- Primaquine sensitivity anemia
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D59.2: its own notes plus those printed at Chapter 3. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Drug-induced enzyme deficiency anemia
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D59.2, its category, or a range that includes it.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disease, diseased See Also: Syndrome;
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Acquired Hemolytic Anemia
hemolytic anemia, the cause of which is not present at birth.
Patient EducationClinical
Anemia
If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D59.2 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D59.2Overview
What is the ICD-10 code for drug-induced nonautoimmune hemolytic anemia?
The ICD-10-CM code for drug-induced nonautoimmune hemolytic anemia is D59.2 (sometimes written as D592). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D59.2 (Acquired hemolytic anemia) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report drug-induced nonautoimmune hemolytic anemia on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D59.2 group to?
When drug-induced nonautoimmune hemolytic anemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 793, 791, 808, 809, 810, with relative weights from 1.0749 to 4.2192 depending on complications. Higher weights mean higher Medicare reimbursement.
Is D59.2 a CC or MCC?
CMS lists D59.2 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 112 closely related codes in its exclusion list.
Does D59.2 need an additional code?
When the condition applies, yes. The Use Additional Code note reads: code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5). The additional code is reported after D59.2.
Does D59.2 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. D59.2 mapped to HCC 46 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 46 (Severe Hematological Disorders), ESRD (V21) category 46 (Severe Hematological Disorders), ESRD (V24) category 46 (Severe Hematological Disorders), and RxHCC Part D (V08) category 96 (Acquired Hemolytic, Aplastic, and Sideroblastic Anemias).
