Anemia due to enzyme disorders (D55) ICD-10-CM
The D55 code range covers anemia due to enzyme disorders with 9 ICD-10-CM diagnosis codes. 7 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- drug-induced enzyme deficiency anemia D59.2
Codes in the D55 Range 9 codes · 7 billable
- D55 Anemia due to enzyme disordersNon-billable
- D55.0 Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
- D55.1 Anemia due to other disorders of glutathione metabolism
- D55.2 Anemia due to disorders of glycolytic enzymesNon-billable
- D55.21 Anemia due to pyruvate kinase deficiency
- D55.29 Anemia due to other disorders of glycolytic enzymes
- D55.3 Anemia due to disorders of nucleotide metabolism
- D55.8 Other anemias due to enzyme disorders
- D55.9 Anemia due to enzyme disorder, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the D55 range.
Anemia due to Enzyme Disorder
Any form of anemia that results from the absence of, or the defective action of, any enzyme.
Favism
Hemolytic anemia due to the ingestion of fava beans or after inhalation of pollen from the Vicia fava plant by persons with glucose-6-phosphate dehydrogenase deficient erythrocytes.
About the D55 Code Range
These anemias result from enzyme disorders and belong to the hemolytic anemia group.
The subdivisions distinguish G6PD deficiency (D55.0), other glutathione metabolism disorders (D55.1), glycolytic enzyme disorders (D55.2), and nucleotide metabolism disorders (D55.3). Within glycolytic enzyme disorders, D55.21 identifies pyruvate kinase deficiency, while D55.29 covers other disorders. D55.8 covers other enzyme-related anemias, and D55.9 identifies anemia due to an unspecified enzyme disorder.
Questions About This Page
How many billable codes are in the D55 range?
Of the 9 codes in this range, 7 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the D55 range classify?
The range classifies anemia due to enzyme disorders. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
