Anemia due to enzyme disorders (D55) ICD-10-CM
The D55 code range covers anemia due to enzyme disorders with 9 ICD-10-CM diagnosis codes. 7 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- drug-induced enzyme deficiency anemia D59.2
Codes in the D55 Range 9 codes · 7 billable
- D55 Anemia due to enzyme disordersNon-billable
- D55.0 Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
- D55.1 Anemia due to other disorders of glutathione metabolism
- D55.2 Anemia due to disorders of glycolytic enzymesNon-billable
- D55.21 Anemia due to pyruvate kinase deficiency
- D55.29 Anemia due to other disorders of glycolytic enzymes
- D55.3 Anemia due to disorders of nucleotide metabolism
- D55.8 Other anemias due to enzyme disorders
- D55.9 Anemia due to enzyme disorder, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the D55 range.
Favism
Hemolytic anemia due to the ingestion of fava beans or after inhalation of pollen from the Vicia fava plant by persons with glucose-6-phosphate dehydrogenase deficient erythrocytes.
About the D55 Code Range
D55 codes classify anemia caused by specific enzyme defects affecting red blood cells, leading primarily to types of hemolytic anemia where red blood cells break down prematurely.
The ICD-10 code for anemia due to enzyme disorders covers a range of enzyme deficiencies. For example, D55.0 is used for anemia from glucose-6-phosphate dehydrogenase (G6PD) deficiency, which is also known as Favism or G-6-PD variant enzyme deficiency anemia. Codes like D55.1 address anemia from glutathione metabolism disorders, including hereditary nonspherocytic hemolytic anemia (HNSHA) variants. Other subcodes cover anemia from glycolytic enzyme problems (D55.2 and D55.21 for pyruvate kinase deficiency), nucleotide metabolism issues (D55.3), and less common enzyme-related anemias (D55.8). When the specific enzyme disorder is not identified, D55.9 applies.
Using these specific codes helps healthcare professionals document and track anemia forms linked to enzyme deficiencies, ensuring precise diagnosis and management. Recognizing synonyms like “chronic non-spherocytic hemolytic anemia” or “enzyme deficiency anemia” clarifies code selection when encountering multiple terminology forms in medical records.
Questions About This Page
How many billable codes are in the D55 range?
Of the 9 codes in this range, 7 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the D55 range classify?
The range classifies anemia due to enzyme disorders. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
