2027 ICD-10-CM Diagnosis Code D59Acquired hemolytic anemia

ICD-10-CM Codes›D50–D89›D55-D59›D59

ICD-10-CM D59
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

D59 is a non-billable ICD-10-CM category code for acquired hemolytic anemia, so it cannot be submitted on claims. Use a more specific code from this category instead, such as D59.0, D59.10, D59.11, and D59.12.

Code Identity

ICD-10-CM Code
D59
Billable Status
No — Non-Billable Category
Code Describes
Acquired hemolytic anemia
Short Description
Acquired hemolytic anemia
Same as the full description in the CMS dataset.
Chapter
D55-D59
Hemolytic anemias

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD59Acquired hemolytic anemia
This CodeD59Acquired hemolytic anemia

Specific Coding for Acquired hemolytic anemiaOverview

Non-specific codes like D59 require more characters. Use one of these billable codes instead:

  • Use D59.0 for Drug-induced autoimmune hemolytic anemia

  • D59.1 for Other autoimmune hemolytic anemias

  • Use D59.10 for Autoimmune hemolytic anemia, unspecified

  • Use D59.11 for Warm autoimmune hemolytic anemia

  • Use D59.12 for Cold autoimmune hemolytic anemia

  • Use D59.13 for Mixed type autoimmune hemolytic anemia

  • Use D59.19 for Other autoimmune hemolytic anemia

  • Use D59.2 for Drug-induced nonautoimmune hemolytic anemia

  • D59.3 for Hemolytic-uremic syndrome

  • Use D59.30 for Hemolytic-uremic syndrome, unspecified

  • Use D59.31 for Infection-associated hemolytic-uremic syndrome

  • Use D59.32 for Hereditary hemolytic-uremic syndrome

  • Use D59.39 for Other hemolytic-uremic syndrome

  • Use D59.4 for Other nonautoimmune hemolytic anemias

  • Use D59.5 for Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]

  • Use D59.6 for Hemoglobinuria due to hemolysis from other external causes

  • Use D59.8 for Other acquired hemolytic anemias

  • Use D59.9 for Acquired hemolytic anemia, unspecified

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to D59: its own notes plus those printed at Chapter 3. A note printed at a category, block or chapter applies to every code under it.

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 3 (D50-D89) Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism applies to 324 codes
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Clinical InformationClinical

  • Acquired Hemolytic Anemia

    hemolytic anemia, the cause of which is not present at birth.

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About D59Overview

What is the ICD-10 code for acquired hemolytic anemia?

D59 is the ICD-10-CM category for acquired hemolytic anemia, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is D59 (Acquired hemolytic anemia) a billable code?

No. This is a category header that groups the codes for acquired hemolytic anemia, and headers cannot be submitted on claims. Claims for acquired hemolytic anemia need a more specific code from this category, such as D59.0, D59.10, and D59.11.