ICD-10-CM Code D59.4

Other nonautoimmune hemolytic anemias

Version 2021 Billable Code

Valid for Submission

D59.4 is a billable code used to specify a medical diagnosis of other nonautoimmune hemolytic anemias. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code D59.4 might also be used to specify conditions or terms like anemia due to infection, anemia due to mechanical damage, anemia due to oxygen, babesiosis, disease due to babesiidae, hemolytic anemia due to babesiosis, etc

Short Description:Other nonautoimmune hemolytic anemias
Long Description:Other nonautoimmune hemolytic anemias

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code D59.4:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Mechanical hemolytic anemia
  • Microangiopathic hemolytic anemia
  • Toxic hemolytic anemia

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code D59.4 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Anemia due to infection
  • Anemia due to mechanical damage
  • Anemia due to oxygen
  • Babesiosis
  • Disease due to Babesiidae
  • Hemolytic anemia due to babesiosis
  • Hemolytic anemia due to Bartonella
  • Hemolytic anemia due to Clostridium welchii
  • Hemolytic anemia due to hyperbaric oxygen
  • Hemolytic anemia due to infection
  • Hemolytic anemia due to malaria
  • Infection due to Clostridium perfringens
  • Intracorpuscular hemolytic anemia
  • Intraerythrocytic parasitosis by Nuttallia
  • Mechanical hemolytic anemia
  • Microangiopathic hemolytic anemia
  • Non-autoimmune hemolytic anemia
  • Polyagglutinable erythrocyte syndrome
  • Toxic hemolytic anemia
  • Traumatic cardiac hemolytic anemia

Convert D59.4 to ICD-9

  • 283.10 - Nonauto hem anemia NOS (Approximate Flag)
  • 283.19 - Oth nonauto hem anemia (Approximate Flag)

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Hemolytic anemias (D55-D59)
      • Acquired hemolytic anemia (D59)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients


Also called: Iron poor blood

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction.

Conditions that may lead to anemia include

  • Heavy periods
  • Pregnancy
  • Ulcers
  • Colon polyps or colon cancer
  • Inherited disorders
  • A diet that does not have enough iron, folic acid or vitamin B12
  • Blood disorders such as sickle cell anemia and thalassemia, or cancer
  • Aplastic anemia, a condition that can be inherited or acquired
  • G6PD deficiency, a metabolic disorder

Anemia can make you feel tired, cold, dizzy, and irritable. You may be short of breath or have a headache.

Your doctor will diagnose anemia with a physical exam and blood tests. Treatment depends on the kind of anemia you have.

NIH: National Heart, Lung, and Blood Institute

  • Anemia (Medical Encyclopedia)
  • Anemia - B12 deficiency (Medical Encyclopedia)
  • Anemia caused by low iron -- infants and toddlers (Medical Encyclopedia)
  • Anemia of chronic disease (Medical Encyclopedia)
  • Anemia of Inflammation and Chronic Disease - NIH
  • Febrile/cold agglutinins (Medical Encyclopedia)
  • Ferritin blood test (Medical Encyclopedia)
  • Hemolytic anemia (Medical Encyclopedia)
  • Iron deficiency anemia (Medical Encyclopedia)
  • Pernicious anemia (Medical Encyclopedia)
  • Vitamin B12 level (Medical Encyclopedia)

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