2024 ICD-10-CM Diagnosis Code D58.9

Hereditary hemolytic anemia, unspecified

ICD-10-CM Code:
ICD-10 Code for:
Hereditary hemolytic anemia, unspecified
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Code Navigator:

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    • Hemolytic anemias
      • Other hereditary hemolytic anemias

D58.9 is a billable diagnosis code used to specify a medical diagnosis of hereditary hemolytic anemia, unspecified. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Unspecified diagnosis codes like D58.9 are acceptable when clinical information is unknown or not available about a particular condition. Although a more specific code is preferable, unspecified codes should be used when such codes most accurately reflect what is known about a patient's condition. Specific diagnosis codes should not be used if not supported by the patient's medical record.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Associated pulmonary arterial hypertension
  • Chronic hemolytic anemia
  • Chronic hemolytic anemia
  • Congenital hemolytic anemia
  • Hemolytic anemia
  • Hemolytic anemia with emphysema AND cutis laxa
  • Hereditary hemolytic anemia
  • Lethal hemolytic anemia and genital anomaly syndrome
  • Megaloblastic anemia due to chronic hemolytic anemia
  • Pulmonary arterial hypertension associated with chronic hemolytic anemia

Clinical Classification

Clinical Information

  • Acquired Hemolytic Anemia

    hemolytic anemia, the cause of which is not present at birth.
  • Autoimmune Hemolytic Anemia|autoimmune hemolytic anemia

    an acquired anemia caused by destruction of the red blood cells by autoantibodies. causes include autoimmune disorders, lymphoproliferative disorders, and infections.
  • Autosomal Recessive Distal Renal Tubular Acidosis-4 with Hemolytic Anemia|DRTA4

    an autosomal recessive type of distal renal tubular acidosis caused by mutation(s) in the slc4a1 gene, encoding band 3 anion transport protein. additionally, it may be characterized by hemolytic anemia.
  • Grade 1 Hemolysis, CTCAE|CTCAE Grade 1 Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)|Grade 1 Hemolysis|Grade 1 Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)

    laboratory evidence of hemolysis only (e.g., direct antiglobulin test; dat; coombs'; schistocytes; decreased haptoglobin)
  • Grade 2 Hemolysis, CTCAE|CTCAE Grade 2 Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)|Grade 2 Hemolysis|Grade 2 Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)

    evidence of hemolysis and >=2 g decrease in hemoglobin
  • Grade 3 Hemolysis, CTCAE|CTCAE Grade 3 Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)|Grade 3 Hemolysis|Grade 3 Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)

    transfusion or medical intervention indicated (e.g., steroids)
  • Grade 4 Hemolysis, CTCAE|CTCAE Grade 4 Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)|Grade 4 Hemolysis|Grade 4 Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)

    life-threatening consequences; urgent intervention indicated
  • Grade 5 Hemolysis, CTCAE|CTCAE Grade 5 Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)|Grade 5 Hemolysis|Grade 5 Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)

  • Hemolysis, CTCAE|Hemolysis|Hemolysis|Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis)

    a disorder characterized by laboratory test results that indicate widespread erythrocyte cell membrane destruction.
  • Hemolytic Anemia

    anemia resulting from the premature destruction of the peripheral blood red cells. it may be congenital or it may be caused by infections, medications, or malignancies.
  • Hemolytic Anemia due to Membrane Defect|Anemia due to Membrane Defect|Hemolytic Anemia due to Erythrocyte Membrane Defect

    a group of inherited hemolytic anemias caused by erythrocyte membrane defects. this includes hereditary pyropoikilocytosis, hereditary spherocytosis and hereditary elliptocytosis.
  • Hereditary Hemolytic Anemia|Congenital Hemolytic Anemia

    a congenital hemolytic anemia caused by defects of the erythrocyte membrane, enzyme deficiencies, or hemoglobinopathies.
  • Immune Hemolytic Anemia|immune complex hemolytic anemia|immunohemolytic anemia

    an acquired anemia resulting from immune-mediated destruction of the red blood cells. causes include autoimmune disorders, blood transfusions, and drugs.
  • Non-Autoimmune Hemolytic Anemia

    hemolytic anemia that is not mediated by immune mechanisms.
  • Pyruvate Kinase Deficiency|Hemolytic Anemia due to Pyruvate Kinase Deficiency

    an inherited metabolic disorder characterized by the deficiency of the erythrocyte enzyme pyruvate kinase. it results in the development of hemolytic anemia.
  • Warm Antibody Autoimmune Hemolytic Anemia

    the most common form of autoimmune hemolytic anemia, in which the autoantibodies react with red blood cells at temperatures greater than or equal to 37 degrees celsius.

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert D58.9 to ICD-9-CM

  • ICD-9-CM Code: 282.9 - Hered hemolytic anem NOS

Patient Education


If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction.

Conditions that may lead to anemia include:

  • Heavy periods
  • Pregnancy
  • Ulcers
  • Colon polyps or colon cancer
  • Inherited disorders
  • A diet that does not have enough iron, folic acid or vitamin B12
  • Blood disorders such as sickle cell anemia and thalassemia, or cancer
  • Aplastic anemia, a condition that can be inherited or acquired
  • G6PD deficiency, a metabolic disorder

Anemia can make you feel tired, cold, dizzy, and irritable. You may be short of breath or have a headache.

Your doctor will diagnose anemia with a physical exam and blood tests. Treatment depends on the kind of anemia you have.

NIH: National Heart, Lung, and Blood Institute

[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.


[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.