Acquired hemolytic anemia (D59) ICD-10-CM
The D59 code range covers acquired hemolytic anemia with 19 ICD-10-CM diagnosis codes. 16 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Codes in the D59 Range 19 codes · 16 billable
- D59 Acquired hemolytic anemiaNon-billable
- D59.0 Drug-induced autoimmune hemolytic anemia
- D59.1 Other autoimmune hemolytic anemiasNon-billable
- D59.10 Autoimmune hemolytic anemia, unspecified
- D59.11 Warm autoimmune hemolytic anemia
- D59.12 Cold autoimmune hemolytic anemia
- D59.13 Mixed type autoimmune hemolytic anemia
- D59.19 Other autoimmune hemolytic anemia
- D59.2 Drug-induced nonautoimmune hemolytic anemia
- D59.3 Hemolytic-uremic syndromeNon-billable
- D59.30 Hemolytic-uremic syndrome, unspecified
- D59.31 Infection-associated hemolytic-uremic syndrome
- D59.32 Hereditary hemolytic-uremic syndrome
- D59.39 Other hemolytic-uremic syndrome
- D59.4 Other nonautoimmune hemolytic anemias
- D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
- D59.6 Hemoglobinuria due to hemolysis from other external causes
- D59.8 Other acquired hemolytic anemias
- D59.9 Acquired hemolytic anemia, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the D59 range.
Atypical Hemolytic Uremic Syndrome
An hereditary hemolytic uremic syndrome associated with variations in the gene that encodes COMPLEMENT FACTOR H, or the related proteins CFHR1 and CFHR3. Disease often progresses to CHRONIC KIDNEY FAILURE without the prodromal symptoms of ENTEROCOLITIS and DIARRHEA that characterize typical hemolytic uremic syndrome.
Babesiosis
A group of tick-borne diseases of mammals including ZOONOSES in humans. They are caused by protozoa of the genus BABESIA, which parasitize erythrocytes, producing hemolysis. In the U.S., the organism's natural host is mice and transmission is by the deer tick IXODES SCAPULARIS.
About the D59 Code Range
ICD-10 code D59 and its subcodes identify various types of acquired hemolytic anemia, a group of disorders where red blood cells are destroyed prematurely due to external or immune-related causes. These codes help specify whether the anemia is autoimmune, drug-induced, infection-associated, or caused by other acquired conditions.
The section covers multiple detailed subcategories, such as D59.0 for drug-induced autoimmune hemolytic anemia—also known as hapten type or immune complex type hemolytic anemia caused by drugs—and D59.1 for other autoimmune hemolytic anemias. It further distinguishes warm autoimmune hemolytic anemia (D59.11) and cold autoimmune hemolytic anemia (D59.12), conditions identified by antibody temperature activity. The hemolytic-uremic syndrome codes (D59.3x) specify whether the syndrome is infection-associated, hereditary, or atypical. Additionally, D59.2 and D59.4 cover nonautoimmune hemolytic anemias, including those caused by drugs, mechanical damage, or infections like babesiosis. Unique conditions such as paroxysmal nocturnal hemoglobinuria (D59.5) and hemoglobinuria from external causes (D59.6) are also addressed. The use of these specific codes ensures precise classification of acquired hemolytic anemias, aiding accurate diagnosis and treatment documentation.
Questions About This Page
How many billable codes are in the D59 range?
Of the 19 codes in this range, 16 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the D59 range classify?
The range classifies acquired hemolytic anemia. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
