Acquired hemolytic anemia (D59)
ICD-10 code D59 and its subcodes identify various types of acquired hemolytic anemia, a group of disorders where red blood cells are destroyed prematurely due to external or immune-related causes. These codes help specify whether the anemia is autoimmune, drug-induced, infection-associated, or caused by other acquired conditions.
The section covers multiple detailed subcategories, such as D59.0 for drug-induced autoimmune hemolytic anemia; also known as hapten type or immune complex type hemolytic anemia caused by drugs; and D59.1 for other autoimmune hemolytic anemias. It further distinguishes warm autoimmune hemolytic anemia (D59.11) and cold autoimmune hemolytic anemia (D59.12), conditions identified by antibody temperature activity. The hemolytic-uremic syndrome codes (D59.3x) specify whether the syndrome is infection-associated, hereditary, or atypical. Additionally, D59.2 and D59.4 cover nonautoimmune hemolytic anemias, including those caused by drugs, mechanical damage, or infections like babesiosis. Unique conditions such as paroxysmal nocturnal hemoglobinuria (D59.5) and hemoglobinuria from external causes (D59.6) are also addressed. The use of these specific codes ensures precise classification of acquired hemolytic anemias, aiding accurate diagnosis and treatment documentation.
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
Hemolytic anemias (D55-D59)
D59 Acquired hemolytic anemia
- D59.0 Drug-induced autoimmune hemolytic anemia
D59.1 Other autoimmune hemolytic anemias
- D59.10 Autoimmune hemolytic anemia, unspecified
- D59.11 Warm autoimmune hemolytic anemia
- D59.12 Cold autoimmune hemolytic anemia
- D59.13 Mixed type autoimmune hemolytic anemia
- D59.19 Other autoimmune hemolytic anemia
- D59.2 Drug-induced nonautoimmune hemolytic anemia
D59.3 Hemolytic-uremic syndrome
- D59.30 Hemolytic-uremic syndrome, unspecified
- D59.31 Infection-associated hemolytic-uremic syndrome
- D59.32 Hereditary hemolytic-uremic syndrome
- D59.39 Other hemolytic-uremic syndrome
- D59.4 Other nonautoimmune hemolytic anemias
- D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
- D59.6 Hemoglobinuria due to hemolysis from other external causes
- D59.8 Other acquired hemolytic anemias
- D59.9 Acquired hemolytic anemia, unspecified
Acquired hemolytic anemia (D59)
Clinical Terms
The following clinical terms provide additional context, helping users better understand the clinical background and common associations for each diagnosis listed in this section. Including related terms alongside ICD-10-CM codes supports coders, billers, and healthcare professionals in improving accuracy, enhancing documentation, and facilitating research or patient education.
Atypical Hemolytic Uremic Syndrome
An hereditary hemolytic uremic syndrome associated with variations in the gene that encodes COMPLEMENT FACTOR H, or the related proteins CFHR1 and CFHR3. Disease often progresses to CHRONIC KIDNEY FAILURE without the prodromal symptoms of ENTEROCOLITIS and DIARRHEA that characterize typical hemolytic uremic syndrome.
Babesiosis
A group of tick-borne diseases of mammals including ZOONOSES in humans. They are caused by protozoa of the genus BABESIA, which parasitize erythrocytes, producing hemolysis. In the U.S., the organism's natural host is mice and transmission is by the deer tick IXODES SCAPULARIS.
