2026 ICD-10-CM Diagnosis Code D59.12Cold autoimmune hemolytic anemia

ICD-10-CM Codes›D50–D89›D55-D59›D59

ICD-10-CM D59.12
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D59.12 is a billable ICD-10-CM diagnosis code for cold autoimmune hemolytic anemia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 808 through 810. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic anemia.

Code Identity

ICD-10-CM Code
D59.12
Billable Status
Yes — Valid for Submission
Code Describes
Cold autoimmune hemolytic anemia
Short Description
Cold autoimmune hemolytic anemia
Same as the full description in the CMS dataset.
Parent Code
D59.1
Other autoimmune hemolytic anemias

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD59Acquired hemolytic anemia
This CodeD59.12Cold autoimmune hemolytic anemia

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Chronic cold agglutinin disease
  • Chronic cold agglutinin disease associated with B-cell neoplasm
  • Chronic hemolytic anemia
  • Chronic idiopathic autoimmune hemolytic anemia
  • Cold agglutinin disease due to and following Epstein-Barr virus infection
  • Cold agglutinin disease due to Mycoplasma pneumonia
  • Cold autoimmune hemolytic anemia
  • Idiopathic chronic cold agglutinin disease
  • Infection caused by Mycoplasma pneumoniae
  • Post-infectious cold agglutinin disease
  • Primary autoimmune hemolytic anemia
  • Primary cold-type hemolytic anemia
  • Secondary autoimmune hemolytic anemia
  • Secondary autoimmune hemolytic anemia co-occurrent and due to lymphoproliferative disorder
  • Secondary cold-type hemolytic anemia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Chronic cold hemagglutinin disease
  • Cold agglutinin disease
  • Cold agglutinin hemoglobinuria
  • Cold type (primary) (secondary) (symptomatic) autoimmune hemolytic anemia
  • Cold type autoimmune hemolytic disease

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • autoimmune
          • cold
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • cold type (primary) (secondary) (symptomatic)
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • primary
          • autoimmune
            • cold type
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • secondary
          • autoimmune
            • cold type
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hemolytic
        • symptomatic
          • autoimmune
            • cold type
    • Cold
      • agglutinin disease or hemoglobinuria (chronic)
    • Cold
      • sensitivity, auto-immune
    • Disease, diseased
      • autoimmune (systemic) NOS
        • hemolytic
          • cold type (primary) (secondary) (symptomatic)
    • Disease, diseased
      • cold
        • agglutinin or hemoglobinuria
    • Disease, diseased
      • cold
        • hemagglutinin (chronic)
    • Disease, diseased
      • hemolytic (newborn)
        • autoimmune
          • cold type (primary) (secondary) (symptomatic)
    • Hemoglobinuria
      • cold (paroxysmal) (with Raynaud's syndrome)
        • agglutinin
    • Sensitive, sensitivity
      • cold, autoimmune

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD002
Hemolytic anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code History & ChangesHistory

Replacement D59.12 replaces the following previously assigned code(s):

  • D59.1 - Other autoimmune hemolytic anemias
FY 2021AddedAdded to the ICD-10-CM code setEffective October 1, 2020.
FY 2022–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D59.12Overview

Is D59.12 (Other autoimmune hemolytic anemias) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report cold autoimmune hemolytic anemia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D59.12 group to?

When cold autoimmune hemolytic anemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0466 to 2.2079 depending on complications. Higher weights mean higher Medicare reimbursement.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.