2027 ICD-10-CM Diagnosis Code D55.0Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
ICD-10-CM Codes›D50–D89›D55-D59›D55
- Billable — Valid for Submission
- Chronic Condition
D55.0 is a billable ICD-10-CM diagnosis code for anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 811 through 812. Coders also document this condition as deficiency of glucose-6-phosphate dehydrogenase. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic anemia.
D55.0 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 48 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 48, ESRD (V21) category 48, and ESRD (V24) category 48 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D55.0 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Deficiency of glucose-6-phosphate dehydrogenase
- Favism
- G-6-PD class I variant anemia
- G-6-PD class II variant anemia
- G-6-PD class III variant anemia
- G-6-PD class IV variant anemia
- G-6-PD class V variant anemia
- G-6-PD variant enzyme deficiency anemia
- Glucose-6-phosphate dehydrogenase deficiency anemia
- Severe deficiency of glucose-6-phosphate dehydrogenase
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D55.0: its own notes plus those printed at D55 and Chapter 3. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Favism
- G6PD deficiency anemia
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia (D75.A)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D55.0, its category, or a range that includes it.
Excludes1 4
These codes carry an Excludes1 note naming D55.0: they are not reported together with it, unless the two conditions are unrelated.
- D75.A Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemiaglucose-6-phosphate dehydrogenase (G6PD) deficiency with anemia (D55.0)
- Block E70-E88 Metabolic disordershemolytic anemias attributable to enzyme disorders (D55.-) names D55.-, which includes this code
- E74.4 Disorders of pyruvate metabolism and gluconeogenesisdisorders of pyruvate metabolism and gluconeogenesis with anemia (D55.-) names D55.-, which includes this code
- Block P50-P61 Hemorrhagic and hematological disorders of newborn
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
Baghdad spring D55.0
G6PD D55.0
favism D55.0
Favism (anemia) D55.0
Poisoning (acute) See Also: Table of Drugs and Chemicals;
fava bean D55.0
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Favism
hemolytic anemia due to the ingestion of fava beans or after inhalation of pollen from the vicia fava plant by persons with glucose-6-phosphate dehydrogenase deficient erythrocytes.
Patient EducationClinical
Anemia
If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D55.0 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D55.0Overview
What is the ICD-10 code for anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency?
The ICD-10-CM code for anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency is D55.0 (sometimes written as D550). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D55.0 (Anemia due to enzyme disorders) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D55.0 group to?
When anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 812, 811, with relative weights from 0.9237 to 1.3991 depending on complications. Higher weights mean higher Medicare reimbursement.
Can D55.0 be reported with D75.A?
Not as a rule. The Excludes1 note on D55.0 lists "glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia (D75.A)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of D55.0?
Under the General Equivalence Mappings, anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency converts to ICD-9-CM 282.2 (glutathione dis anemia). The mapping is approximate, so confirm the match fits the documentation.
Does D55.0 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. D55.0 mapped to HCC 48 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 48 (Coagulation Defects and Other Specified Hematological Disorders), ESRD (V21) category 48 (Coagulation Defects and Other Specified Hematological Disorders), and ESRD (V24) category 48 (Coagulation Defects and Other Specified Hematological Disorders).
