2026 ICD-10-CM Diagnosis Code E88.819Insulin resistance, unspecified

AHRQ’s CCSR groups this code into broader clinical categories.

• Insulin Resistance

  diminished effectiveness of insulin in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

• Metabolic Syndrome

  a cluster of symptoms that are risk factors for cardiovascular diseases and type 2 diabetes mellitus. the major components of metabolic syndrome include abdominal obesity; atherogenic dyslipidemia; hypertension; hyperglycemia; insulin resistance; a proinflammatory state; and a prothrombotic (thrombosis) state.

• Drug Resistance

  diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. it should be differentiated from drug tolerance which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.

• Drug Resistance, Bacterial

  the ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. this resistance may be acquired through gene mutation or foreign dna in transmissible plasmids (r factors).

• Drug Resistance, Fungal

  the ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. this resistance may be acquired through gene mutation.

• Drug Resistance, Microbial

  the ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. this resistance may be acquired through gene mutation or foreign dna in transmissible plasmids (r factors).

• Drug Resistance, Multiple

  simultaneous resistance to several structurally and functionally distinct drugs.

• Drug Resistance, Multiple, Bacterial

  the ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. this resistance may be acquired through gene mutation or foreign dna in transmissible plasmids (r factors).

• Drug Resistance, Multiple, Fungal

  the ability of fungi to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. this resistance phenotype may be attributed to multiple gene mutations.

• Drug Resistance, Multiple, Viral

  the ability of viruses to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. this resistance phenotype may be attributed to multiple gene mutation.

• Drug Resistance, Neoplasm

  resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.

• Drug Resistance, Viral

  the ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. this resistance is acquired through gene mutation.

• Acanthosis Nigricans

  a circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. it occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.

• Drug Tolerance

  progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. it should be differentiated from drug resistance wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. it should also be differentiated from maximum tolerated dose and no-observed-adverse-effect level.

• Homeostatic Model Assessment of Insulin Resistance

  an assessment of beta-cell function and insulin resistance based on fasting blood glucose and insulin concentrations.

• Hyperandrogenism, Insulin Resistance, Acanthosis Nigricans Syndrome|HAIR-AN Syndrome

  a condition characterized by hyperandrogenism, insulin resistance, and acanthosis nigricans, typically associated with obesity in teenage girls. it is considered to be a subtype of polycystic ovarian syndrome, but may occur in male individuals. etiology is unclear, but some cases may be associated with mutations affecting the tyrosine kinase domain of the insulin receptor.

• Insulin Receptor Mutation - Associated Insulin Resistance Syndromes

  insulin resistance caused by inactivating mutation(s) in the insr gene encoding the insulin receptor.

• Insulin Resistance

  decreased sensitivity to circulating insulin which may result in acanthosis nigicrans, elevated insulin level or hyperglycemia.

• Insulin Resistance Measurement|INSULINR|Insulin Resistance|Insulin Resistance

  the determination of the insulin resistance (cells inability to respond to insulin) in a biological specimen.

• Insulin Resistance Syndrome

  a cluster of closely related metabolic abnormalities associated with insulin resistance that confer an increased risk of the development of type 2 diabetes and cardiovascular disease. these abnormalities may include obesity, high blood pressure, abnormal cholesterol levels, proteinuria, and/or polycystic ovary syndrome.

• Insulin Resistant Diabetes Mellitus with Acanthosis Nigricans and Hyperandrogenism|Type A Insulin Resistance Syndrome

  a syndrome of insulin resistance caused by mutation(s) in the insr gene, encoding the insulin receptor. this condition is characterized by a clinical triad of hyperinsulinemia, acanthosis nigricans, and hyperandrogenism without lipodystrophy. this is the least severe of a spectrum of disorders; the other two conditions are rabson-mendenhall syndrome and donohoe syndrome.

• Obesity-Associated Insulin Resistance

  insulin resistance associated with obesity, which may be attributed in part to impaired insulin signaling in target tissues, or impaired insulin-stimulated glucose transport due to reduced expression of the glucose transporter protein 4.

• Acanthosis Nigricans

  a melanotic cutaneous lesion that develops in the axilla and other body folds. it may be idiopathic, drug-induced, or it may be associated with the presence of an endocrine disorder or malignancy.

Prediabetes

Prediabetes means that your blood glucose, or blood sugar, levels are higher than normal but not high enough to be called diabetes. Glucose comes from the foods you eat. Too much glucose in your blood can damage your body over time.

The full article covers:

• What is prediabetes?
• What causes prediabetes?
• Who is at risk for prediabetes?
• What are the symptoms of prediabetes?
• How is prediabetes diagnosed?
• If I have prediabetes, will I get diabetes?
• Can prediabetes be prevented?

Read the full article at MedlinePlus

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