2027 ICD-10-CM Diagnosis Code E88.818Other insulin resistance
ICD-10-CM Codes›E00–E89›E70-E88›E88
- Billable — Valid for Submission
- Chronic Condition
E88.818 is a billable ICD-10-CM diagnosis code for other insulin resistance. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 642. Coders also document this condition as diabetes mellitus due to genetic defect in insulin action. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Diabetes mellitus due to genetic defect in insulin action
- Genetic non-syndromic childhood obesity
- Insulin resistance
- Insulin resistance - type B
- Malabsorption of glucose
- Severe early-onset obesity insulin resistance syndrome due to SH2B1 deficiency
- Severe obesity
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E88.818: its own notes plus those printed at E88.81, E88, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Insulin resistance syndrome, Type B
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- histiocytosis X (chronic) (C96.6)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- Ehlers-Danlos syndromes (Q79.6-)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- codes for associated manifestations, such as:
- obesity (E66.-)
- codes for associated conditions
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E88.818, its category, or a range that includes it.
Excludes1 1
These codes carry an Excludes1 note naming E88.818: they are not reported together with it, unless the two conditions are unrelated.
Use Additional Code 1
These codes say to use an additional code from the note, and E88.818 is one of the codes named.
Index to Diseases and InjuriesGuidance
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Metabolic Syndrome
Metabolic syndrome is the name for a group of risk factors for heart disease, diabetes, and other health problems. You can have just one risk factor, but people often have several of them together. When you have at least three of them, it is called metabolic syndrome. These risk factors include:
The full article covers:
- What is metabolic syndrome?
- What causes metabolic syndrome?
- Who is at risk for metabolic syndrome?
- What are the symptoms of metabolic syndrome?
- How is metabolic syndrome diagnosed?
- What are the treatments for metabolic syndrome?
- Can metabolic syndrome be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Code History & ChangesHistory
Replacement E88.818 replaces the following previously assigned code(s):
- E88.81 - Metabolic syndrome
- E88.81 - Metabolic syndrome and other insulin resistance
Questions About E88.818Overview
What is the ICD-10 code for other insulin resistance?
The ICD-10-CM code for other insulin resistance is E88.818 (sometimes written as E88818). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E88.818 (Metabolic syndrome and other insulin resistance) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other insulin resistance on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E88.818 group to?
When other insulin resistance is the principal diagnosis on an inpatient stay, it groups to MS-DRG 642 (inborn and Other Disorders of Metabolism), which carries a relative weight of 1.3226. Higher weights mean higher Medicare reimbursement.
Can E88.818 be reported with C96.6?
Not as a rule. The Excludes1 note at E88, which applies to E88.818, lists "histiocytosis X (chronic) (C96.6)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
