2026 ICD-10-CM Diagnosis Code E88.10Lipodystrophy, unspecified

ICD-10-CM Codes›E00–E89›E70-E88›E88

ICD-10-CM E88.10
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E88.10 is a billable ICD-10-CM diagnosis code for lipodystrophy, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026).

Code Identity

ICD-10-CM Code
E88.10
Billable Status
Yes — Valid for Submission
Code Describes
Lipodystrophy, unspecified
Short Description
Lipodystrophy, unspecified
Same as the full description in the CMS dataset.
Parent Code
E88.1
Lipodystrophy, not elsewhere classified

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE88Other and unspecified metabolic disorders
This CodeE88.10Lipodystrophy, unspecified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Congenital anomaly of subcutaneous tissue
  • Congenital generalized lipodystrophy
  • Diabetes mellitus due to genetic defect in insulin action
  • Genetic lipodystrophy
  • Lipoatrophic diabetes
  • Lipoatrophy
  • Lipoatrophy and lipodystrophy
  • Lipoatrophy caused by antiretroviral drug
  • Lipodystrophy
  • Lipodystrophy caused by antiretroviral drug
  • Lipodystrophy due to juvenile dermatomyositis
  • Lipodystrophy due to peptidic growth factors deficiency
  • Lipodystrophy, intellectual disability, deafness syndrome
  • Marfan's syndrome
  • Nakajo-Nishimura syndrome
  • Progeroid and marfanoid aspect, lipodystrophy syndrome
  • Severe neurodegenerative syndrome with lipodystrophy
  • Widespread lipoatrophy

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Lipodystrophy NOS

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Lipodystrophy

Clinical InformationClinical

  • HIV-Associated Lipodystrophy Syndrome

    defective metabolism leading to fat maldistribution in patients infected with hiv. the etiology appears to be multifactorial and probably involves some combination of infection-induced alterations in metabolism, direct effects of antiretroviral therapy, and patient-related factors.

  • Lipodystrophy

    a collection of heterogenous conditions resulting from defective lipid metabolism and characterized by adipose tissue atrophy. often there is redistribution of body fat resulting in peripheral fat wasting and central adiposity. they include generalized, localized, congenital, and acquired lipodystrophy.

  • Lipodystrophy, Congenital Generalized

    congenital disorders, usually autosomal recessive, characterized by severe generalized lack of adipose tissue, extreme insulin resistance, and hypertriglyceridemia.

  • Lipodystrophy, Familial Partial

    inherited conditions characterized by the partial loss of adipose tissue, either confined to the extremities with normal or increased fat deposits on the face, neck and trunk (type 1), or confined to the loss of subcutaneous fat from the limbs and trunk (type 2). type 3 is associated with mutation in the gene encoding peroxisome proliferator-activated receptor gamma.

  • Lipomatosis, Multiple Symmetrical

    a condition characterized by the growth of unencapsulated masses of adipose tissue symmetrically deposited around the neck, shoulders, or other sites around the body.

  • Panniculitis, Peritoneal

    inflammation of the underlying layer of adipose tissue (panniculus) of the peritoneum, usually of the mesentery or the omentum. there are several forms with various names and are usually characterized by infiltration of lymphocytes and neutrophils, fat necrosis, and fibrosis.

  • Whipple Disease

    a chronic systemic infection by a gram-positive bacterium, tropheryma whippelii, mainly affecting the small intestine but also the joints; cardiovascular system; and the central nervous system. the disease is characterized by fat deposits in the intestinal mucosa and lymph nodes, malabsorption, diarrhea with fatty stools, malnutrition, and arthritis.

  • HIV

    human immunodeficiency virus. a non-taxonomic and historical term referring to any of two species, specifically hiv-1 and/or hiv-2. prior to 1986, this was called human t-lymphotropic virus type iii/lymphadenopathy-associated virus (htlv-iii/lav). from 1986-1990, it was an official species called hiv. since 1991, hiv was no longer considered an official species name; the two species were designated hiv-1 and hiv-2.

  • Adipose Tissue

    specialized connective tissue composed of fat cells (adipocytes). it is the site of stored fats, usually in the form of triglycerides. in mammals, there are two types of adipose tissue, the white fat and the brown fat. their relative distributions vary in different species with most adipose tissue being white.

Code History & ChangesHistory

New Code E88.10 was added to the ICD-10-CM code set for FY 2026, effective October 1, 2025.

Replacement E88.10 replaces the following previously assigned code(s):

  • E88.1 - Lipodystrophy, not elsewhere classified
FY 2026AddedAdded to the ICD-10-CM code setEffective October 1, 2025.
FY 2026CurrentRevised in the current code setEffective October 1, 2025 through September 30, 2026.

Questions About E88.10Overview

Is E88.10 (Lipodystrophy, not elsewhere classified) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report lipodystrophy, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.