2026 ICD-10-CM Diagnosis Code E25.9Adrenogenital disorder, unspecified

ICD-10-CM Codes›E00–E89›E20-E35›E25

ICD-10-CM E25.9
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E25.9 is a billable ICD-10-CM diagnosis code for adrenogenital disorder, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E25.9
Billable Status
Yes — Valid for Submission
Code Describes
Adrenogenital disorder, unspecified
Short Description
Adrenogenital disorder, unspecified
Same as the full description in the CMS dataset.
Parent Code
E25
Adrenogenital disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE25Adrenogenital disorders
This CodeE25.9Adrenogenital disorder, unspecified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired adrenogenital syndrome
  • Adrenal hyperfunction
  • Adrenal virilism
  • Adrenogenital disorder
  • Drug-induced virilization
  • Female adrenal virilization
  • Genitalia Tanner Stage 1
  • Genitalia Tanner Stage 2
  • Genitalia Tanner Stage 3
  • Genitalia Tanner Stage 4
  • Genitalia Tanner Stage 5
  • Macrogenitosomia
  • Macrogenitosomia praecox due to pineal disorder
  • Male sexual precocity with adrenal hyperplasia
  • Masculinized female
  • Tanner boys genital development - finding
  • Testicular lesion of adrenogenital syndrome
  • Virilization
  • Virilization-adrenogenital syndrome
  • Virilizing adrenal tumor
  • Virilizing syndrome of adrenal origin

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Adrenogenital syndrome NOS

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Adrenogenital syndrome
    • Disorder(of)
      • adrenogenital
    • Hyperfunction
      • adrenal cortex, not associated with Cushing's syndrome
        • virilism
    • Hyperplasia, hyperplastic
      • adrenal (capsule) (cortex) (gland)
        • with
          • sexual precocity (male)
    • Hyperplasia, hyperplastic
      • adrenal (capsule) (cortex) (gland)
        • with
          • virilism, adrenal
    • Hyperplasia, hyperplastic
      • adrenal (capsule) (cortex) (gland)
        • with
          • virilization (female)
    • Macrogenitosomia(adrenal) (male) (praecox)
    • Masculinization(female) with adrenal hyperplasia
    • Precocity, sexual(constitutional) (cryptogenic) (female) (idiopathic) (male)
      • with adrenal hyperplasia
    • Syndrome
      • adrenogenital
    • Virilism(adrenal)
    • Virilization(female) (suprarenal)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Abnormal Virilization|Masculinization|Virilism|Virilism|Virilization|Virilization

    the abnormal development of male secondary sexual characteristics due to excessive androgens.

  • Female Virilization|Virilization in Girls

    the development of male secondary sexual characteristics (such as hirsutism, deepening of the voice, or clitoral enlargement) in girls or adult females.

  • Fetal Virilization|Fetal Virilism|Fetal Virilism

    inappropriate secondary sex characteristics in the neonate usually due to in utero androgen exposure.

  • Grade 1 Virilization, CTCAE|Grade 1 Virilization

    mild symptoms; intervention not indicated

  • Grade 2 Virilization, CTCAE|Grade 2 Virilization

    moderate symptoms; medical intervention indicated

  • Normal Virilization

    the normal development of male secondary sexual characteristics (such as hirsutism, deepening of the voice) in pubertal boys due to testosterone effects.

  • Virilization

    the development of normal male puberty due to testosterone effect or the abnormal development of male secondary sexual characteristics in children and females due to excessive androgens.

  • Virilization, CTCAE|Virilization|Virilization

    a disorder characterized by inappropriate masculinization occurring in a female or prepubertal male.

Patient EducationClinical

Adrenal Gland Disorders

Your adrenal glands are two small organs that sit on top of each kidney. The adrenal glands make different types of hormones you need to stay alive and healthy. Hormones are chemicals that travel in your bloodstream and control how different parts of your body work.

The full article covers:

  • What are adrenal glands?
  • What are adrenal gland disorders?
  • What causes adrenal gland disorders?
  • How are adrenal gland disorders diagnosed?
  • What are the treatments for adrenal gland disorders?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E25.9 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
255.2 Adrenogenital disorders
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E25.9Overview

Is E25.9 (Adrenogenital disorders) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report adrenogenital disorder, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E25.9 group to?

When adrenogenital disorder, unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E25.9?

Under the General Equivalence Mappings, adrenogenital disorder, unspecified converts to ICD-9-CM 255.2 (adrenogenital disorders). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.