2026 ICD-10-CM Diagnosis Code E22.2Syndrome of inappropriate secretion of antidiuretic hormone

ICD-10-CM Codes›E00–E89›E20-E35›E22

ICD-10-CM E22.2
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E22.2 is a billable ICD-10-CM diagnosis code for syndrome of inappropriate secretion of antidiuretic hormone. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. Coders also document this condition as ectopic syndrome of inappropriate secretion of antidiuretic hormone. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Pituitary disorders.

Code Identity

ICD-10-CM Code
E22.2
Billable Status
Yes — Valid for Submission
Code Describes
Syndrome of inappropriate secretion of antidiuretic hormone
Short Description
Syndrome of inappropriate secretion of antidiuretic hormone
Same as the full description in the CMS dataset.
Parent Code
E22
Hyperfunction of pituitary gland

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE22Hyperfunction of pituitary gland
This CodeE22.2Syndrome of inappropriate secretion of antidiuretic hormone

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Ectopic syndrome of inappropriate secretion of antidiuretic hormone
  • Pituitary syndrome of inappropriate vasopressin secretion
  • Syndrome of inappropriate vasopressin secretion

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Antidiuretic hormone syndrome
    • Hypersecretion
      • hormone (s)
        • antidiuretic
    • Inappropriate
      • secretion
        • antidiuretic hormone (ADH) (excessive)
    • Inappropriate
      • secretion
        • pituitary (posterior)
    • Increase, increased
      • function
        • pituitary (gland) (anterior) (lobe)
          • posterior
    • Perversion, perverted
      • function
        • pituitary gland
          • posterior lobe
    • Schwartz-Bartter syndrome
    • Secretion
      • antidiuretic hormone, inappropriate
    • Secretion
      • hormone
        • antidiuretic, inappropriate (syndrome)
    • Syndrome
      • inappropriate secretion of antidiuretic hormone
    • Syndrome
      • Schwartz-Bartter

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END013
Pituitary disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E22.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
253.6 Neurohypophysis dis NEC
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E22.2Overview

Is E22.2 (Hyperfunction of pituitary gland) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report syndrome of inappropriate secretion of antidiuretic hormone on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E22.2 group to?

When syndrome of inappropriate secretion of antidiuretic hormone is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E22.2?

Under the General Equivalence Mappings, syndrome of inappropriate secretion of antidiuretic hormone converts to ICD-9-CM 253.6 (neurohypophysis dis NEC). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.