2026 ICD-10-CM Diagnosis Code D80.6Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia

ICD-10-CM Codes›D50–D89›D80-D89›D80

ICD-10-CM D80.6
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D80.6 is a billable ICD-10-CM diagnosis code for antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 808 through 810. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.

Code Identity

ICD-10-CM Code
D80.6
Billable Status
Yes — Valid for Submission
Code Describes
Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
Short Description
Antibody defic w near-norm immunoglob or w hyperimmunoglob
Parent Code
D80
Immunodeficiency with predominantly antibody defects

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD80-D89Certain disorders involving the immune mechanism
CategoryD80Immunodeficiency with predominantly antibody defects
This CodeD80.6Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
  • Anti-Haemophilus influenzae type b capsular polysaccharide antibody deficiency
  • Anti-meningococcal polysaccharide A antibody deficiency
  • Anti-meningococcal polysaccharide C antibody deficiency
  • Anti-pneumococcal polysaccharide antibody deficiency
  • Anti-polysaccharide antibody deficiency
  • Anti-protein antibody deficiency
  • Anti-staphylococcal antibody deficiency
  • Chromosome 18 syndromes and antibody deficiency
  • Humoral immune defect
  • Immune defect
  • Specific antibody deficiency

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Deficiency, deficient
      • antibody with
        • hyperimmunoglobulinemia
    • Deficiency, deficient
      • antibody with
        • near-normal immunoglobins
    • Immunodeficiency
      • with
        • hyperimmunoglobulinemia
    • Immunodeficiency
      • antibody with
        • hyperimmunoglobulinemia
    • Immunodeficiency
      • antibody with
        • near-normal immunoglobulins

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD008
Immunity disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

The full article covers:

  • What is the immune system?
  • What are the parts of the immune system?
  • How does the immune system work?
  • What are the types of immunity?
  • What can go wrong with the immune system?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D80.6 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
279.09 Humoral immunity def NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D80.6Overview

Is D80.6 (Immunodeficiency with predominantly antibody defects) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D80.6 group to?

When antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0466 to 2.2079 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D80.6?

Under the General Equivalence Mappings, antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia converts to ICD-9-CM 279.09 (humoral immunity def NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.