2027 ICD-10-CM Diagnosis Code D80.6Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
ICD-10-CM Codes›D50–D89›D80-D89›D80
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Chronic Condition
D80.6 is a billable ICD-10-CM diagnosis code for antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 808 through 810. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 44 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.
D80.6 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 47 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 47, ESRD (V21) category 47, ESRD (V24) category 47, and RxHCC Part D (V08) category 99 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D80.6 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
- Anti-Haemophilus influenzae type b capsular polysaccharide antibody deficiency
- Anti-meningococcal polysaccharide A antibody deficiency
- Anti-meningococcal polysaccharide C antibody deficiency
- Anti-pneumococcal polysaccharide antibody deficiency
- Anti-polysaccharide antibody deficiency
- Anti-protein antibody deficiency
- Anti-staphylococcal antibody deficiency
- Chromosome 18 syndromes and antibody deficiency
- Humoral immune defect
- Immune defect
- Specific antibody deficiency
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D80.6: its own notes plus those printed at block D80-D89 and Chapter 3. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- human immunodeficiency virus [HIV] disease (B20)
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D80.6, its category, or a range that includes it.
Excludes1 2
These codes carry an Excludes1 note naming D80.6: they are not reported together with it, unless the two conditions are unrelated.
Code First 1
These codes say to code first a condition named in the note, and D80.6 is one of the conditions named.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Immune System and Disorders
Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.
The full article covers:
- What is the immune system?
- What are the parts of the immune system?
- How does the immune system work?
- What are the types of immunity?
- What can go wrong with the immune system?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D80.6 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D80.6Overview
Is D80.6 (Immunodeficiency with predominantly antibody defects) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D80.6 group to?
When antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0749 to 2.1706 depending on complications. Higher weights mean higher Medicare reimbursement.
Is D80.6 a CC or MCC?
CMS lists D80.6 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 44 closely related codes in its exclusion list.
Can D80.6 be reported with M35.9?
Not as a rule. The Excludes1 note at block D80-D89, which applies to D80.6, lists "autoimmune disease (systemic) NOS (M35.9)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of D80.6?
Under the General Equivalence Mappings, antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia converts to ICD-9-CM 279.09 (humoral immunity def NEC). The mapping is approximate, so confirm the match fits the documentation.
Does D80.6 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. D80.6 mapped to HCC 47 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 47 (Disorders of Immunity), ESRD (V21) category 47 (Disorders of Immunity), ESRD (V24) category 47 (Disorders of Immunity), and RxHCC Part D (V08) category 99 (Immune Disorders).
