2027 ICD-10-CM Diagnosis Code D59.6Hemoglobinuria due to hemolysis from other external causes
ICD-10-CM Codes›D50–D89›D55-D59›D59
- Billable — Valid for Submission
- Risk Adjusts — HCC 109
- Chronic Condition
D59.6 is a billable ICD-10-CM diagnosis code for hemoglobinuria due to hemolysis from other external causes. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 791, 793, 808 through 810. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic anemia.
For Medicare Advantage risk adjustment, D59.6 maps to CMS-HCC Category 109 (Acquired Hemolytic, Aplastic, and Sideroblastic Anemias) under the V28 model, adding a risk factor of about 1.144 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D59.6 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Chronic hemolytic anemia
- Hemoglobinuria - external causation
- Hemoglobinuria due to hemolysis from external causes
- Idiopathic paroxysmal cold hemoglobinuria
- March hemoglobinuria
- Paroxysmal cold hemoglobinuria
- Paroxysmal cold hemoglobinuria associated with tertiary syphilis
- Post-viral paroxysmal cold hemoglobinuria
- Primary autoimmune hemolytic anemia
- Secondary cold-type hemolytic anemia
- Secondary paroxysmal cold hemoglobinuria
- Sports anemia
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D59.6: its own notes plus those printed at Chapter 3. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Hemoglobinuria from exertion
- March hemoglobinuria
- Paroxysmal cold hemoglobinuria
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- hemoglobinuria NOS (R82.3)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- code (Chapter 20) to identify external cause
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D59.6, its category, or a range that includes it.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disease, diseased See Also: Syndrome;
Harley's disease D59.6
paroxysmal D59.6
intermittent D59.6
march D59.6
paroxysmal (cold) D59.6
hemoglobinuria D59.6
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Acquired Hemolytic Anemia
hemolytic anemia, the cause of which is not present at birth.
Patient EducationClinical
Anemia
If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D59.6 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D59.6Overview
What is the ICD-10 code for hemoglobinuria due to hemolysis from other external causes?
The ICD-10-CM code for hemoglobinuria due to hemolysis from other external causes is D59.6 (sometimes written as D596). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D59.6 (Acquired hemolytic anemia) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report hemoglobinuria due to hemolysis from other external causes on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D59.6 group to?
When hemoglobinuria due to hemolysis from other external causes is the principal diagnosis on an inpatient stay, it groups to MS-DRG 793, 791, 808, 809, 810, with relative weights from 1.0749 to 4.2192 depending on complications. Higher weights mean higher Medicare reimbursement.
Can D59.6 be reported with R82.3?
Not as a rule. The Excludes1 note on D59.6 lists "hemoglobinuria NOS (R82.3)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does D59.6 need an additional code?
When the condition applies, yes. The Use Additional Code note reads: code (Chapter 20) to identify external cause. The additional code is reported after D59.6.
What HCC is D59.6?
D59.6 (hemoglobinuria due to hemolysis from other external causes) maps to CMS-HCC Category 109 (Acquired Hemolytic, Aplastic, and Sideroblastic Anemias), commonly written as HCC 109, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 46 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 96.
Does D59.6 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, D59.6 adds a risk adjustment factor of about 1.144 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.529 to 1.815 depending on the payment segment). HCC 109 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 109 category page.
