2027 ICD-10-CM Diagnosis Code E78.89Other lipoprotein metabolism disorders
ICD-10-CM Codes›E00–E89›E70-E88›E78
- Billable — Valid for Submission
- Chronic Condition
E78.89 is a billable ICD-10-CM diagnosis code for other lipoprotein metabolism disorders. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 642. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
E78.89 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 47 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E78.89 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model, but it maps to payment categories in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Combined heterozygous low density lipoprotein receptor co-occurrent with low density lipoprotein receptor adaptor protein 1 mutations
- Combined pancreatic lipase and colipase deficiency
- Deficiency of glycerophosphocholine phosphodiesterase
- Dyslipidemia
- Dyslipidemia due to type 2 diabetes mellitus
- Dyslipidemia with high density lipoprotein below reference range and triglyceride above reference range due to type 2 diabetes mellitus
- Familial disease with storage of sterols
- Farber's lipogranulomatosis
- Fat overload syndrome
- GM3 synthase deficiency
- Hepatic lipase deficiency
- Heterozygous sitosterolemia
- High density lipoprotein below reference range
- Homozygous sitosterolemia
- Hypolipidemia
- Intestinal lipofuscinosis
- Lipid proteinosis
- Lipofuscinosis
- Lipogranulomatosis subcutanea of Rothmann and Makai
- Lipoprotein above reference range
- Lipoprotein below reference range
- Lobular panniculitis
- Low density lipoprotein cholesterol above reference range
- Low density lipoprotein receptor adaptor protein 1 mutation
- Low density lipoprotein receptor mutation
- Lysosomal acid lipase deficiency
- Male emopamil-binding protein disorder with neurological defect
- OCRL gene related phosphatidylinositol 4,5-bisphosphate-5-phosphatase deficiency
- Proteinosis
- Sitosterolemia
- Triglyceride level - finding
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E78.89: its own notes plus those printed at E78, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- Ehlers-Danlos syndromes (Q79.6-)
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E78.89, its category, or a range that includes it.
Excludes1 1
These codes carry an Excludes1 note naming E78.89: they are not reported together with it, unless the two conditions are unrelated.
- L98.6 Other infiltrative disorders of the skin and subcutaneous tissuehyalinosis cutis et mucosae (E78.89)
Excludes2 2
These codes carry an Excludes2 note naming E78.89: its condition is not part of those codes, and both may be reported when the patient has both.
- E88.0 Disorders of plasma-protein metabolism, not elsewhere classifieddisorder of lipoprotein metabolism (E78.-) names E78.-, which includes this code
- Block R70-R79 Abnormal findings on examination of blood, without diagnosisabnormalities of lipids (E78.-) names E78.-, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disorder (of) See Also: Disease;
specified NEC E78.89
specified NEC E78.89
cutis (et mucosae) E78.89
Lipogranulomatosis E78.89
Lipoid See Also: condition;
proteinosis of Urbach E78.89
Urbach's lipoid proteinosis E78.89
Urbach-Wiethe disease E78.89
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Lipoid Proteinosis of Urbach and Wiethe
an autosomal recessive disorder characterized by glassy degenerative thickening (hyalinosis) of skin; mucosa; and certain viscera. this disorder is caused by mutation in the extracellular matrix protein 1 gene (ecm1). clinical features include hoarseness and skin eruption due to widespread deposition of hyalin.
Patient EducationClinical
Lipid Metabolism Disorders
Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E78.89 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E78.89Overview
What is the ICD-10 code for other lipoprotein metabolism disorders?
The ICD-10-CM code for other lipoprotein metabolism disorders is E78.89 (sometimes written as E7889). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E78.89 (Other disorders of lipoprotein metabolism) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other lipoprotein metabolism disorders on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E78.89 group to?
When other lipoprotein metabolism disorders is the principal diagnosis on an inpatient stay, it groups to MS-DRG 642 (inborn and Other Disorders of Metabolism), which carries a relative weight of 1.3226. Higher weights mean higher Medicare reimbursement.
Can E78.89 be reported with a code from E34.5?
Not as a rule. The Excludes1 note at block E70-E88, which applies to E78.89, lists "androgen insensitivity syndrome (E34.5-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of E78.89?
Under the General Equivalence Mappings, other lipoprotein metabolism disorders converts to ICD-9-CM 272.8 (lipoid metabol dis NEC). The mapping is approximate, so confirm the match fits the documentation.
Does E78.89 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage: E78.89 maps to no category in the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 47 (Disorders of Lipoid Metabolism).
