2026 ICD-10-CM Diagnosis Code E78.89Other lipoprotein metabolism disorders

ICD-10-CM Codes›E00–E89›E70-E88›E78

ICD-10-CM E78.89
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E78.89 is a billable ICD-10-CM diagnosis code for other lipoprotein metabolism disorders. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E78.89
Billable Status
Yes — Valid for Submission
Code Describes
Other lipoprotein metabolism disorders
Short Description
Other lipoprotein metabolism disorders
Same as the full description in the CMS dataset.
Parent Code
E78.8
Other disorders of lipoprotein metabolism

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE78Disorders of lipoprotein metabolism and other lipidemias
This CodeE78.89Other lipoprotein metabolism disorders

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Combined heterozygous low density lipoprotein receptor co-occurrent with low density lipoprotein receptor adaptor protein 1 mutations
  • Combined pancreatic lipase and colipase deficiency
  • Deficiency of glycerophosphocholine phosphodiesterase
  • Dyslipidemia
  • Dyslipidemia due to type 2 diabetes mellitus
  • Dyslipidemia with high density lipoprotein below reference range and triglyceride above reference range due to type 2 diabetes mellitus
  • Familial disease with storage of sterols
  • Farber's lipogranulomatosis
  • Fat overload syndrome
  • GM3 synthase deficiency
  • Hepatic lipase deficiency
  • Heterozygous sitosterolemia
  • High density lipoprotein below reference range
  • Homozygous sitosterolemia
  • Hypolipidemia
  • Intestinal lipofuscinosis
  • Lipid proteinosis
  • Lipofuscinosis
  • Lipogranulomatosis subcutanea of Rothmann and Makai
  • Lipoprotein above reference range
  • Lipoprotein below reference range
  • Lobular panniculitis
  • Low density lipoprotein cholesterol above reference range
  • Low density lipoprotein receptor adaptor protein 1 mutation
  • Low density lipoprotein receptor mutation
  • Lysosomal acid lipase deficiency
  • Male emopamil-binding protein disorder with neurological defect
  • Proteinosis
  • Sitosterolemia
  • Triglyceride level - finding

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Disorder(of)
      • lipoprotein
        • metabolism
          • specified NEC
    • Disorder(of)
      • metabolism NOS
        • lipoprotein
          • specified NEC
    • Hyalinosis
      • cutis (et mucosae)
    • Lipogranulomatosis
    • Lipoid
      • proteinosis of Urbach
    • Proteinosis
      • lipid or lipoid (of Urbach)
    • Urbach's lipoid proteinosis
    • Urbach-Wiethe disease

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Sitosterolemia

    an extremely rare autosomal recessive inherited disorder caused by mutations in the abcg5 or abcg8 genes. it is characterized by a defective sterolin transporter that impairs the elimination of plant sterols and, to a lesser degree, cholesterol from the body. these fatty substances build up in the tissues including arteries and skin, resulting in atherosclerosis and xanthomas.

  • CDISC Dyslipidemia Therapeutic Area User Guide Version 1.0|Dyslipidemia Therapeutic Area User Guide v1.0

    the 1.0 version of the cdisc dyslipidemia therapeutic area user guide.

  • Dyslipidemia

    a lipoprotein metabolism disorder characterized by decreased levels of high-density lipoproteins, or elevated levels of plasma cholesterol, low-density lipoproteins and/or triglycerides.

Patient EducationClinical

Lipid Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E78.89 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
272.8 Lipoid metabol dis NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E78.89Overview

Is E78.89 (Other disorders of lipoprotein metabolism) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other lipoprotein metabolism disorders on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What is the ICD-9 equivalent of E78.89?

Under the General Equivalence Mappings, other lipoprotein metabolism disorders converts to ICD-9-CM 272.8 (lipoid metabol dis NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.