2026 ICD-10-CM Diagnosis Code E72.81Disorders of gamma aminobutyric acid metabolism
ICD-10-CM Codes›E00–E89›E70-E88›E72
- Billable — Valid for Submission
- Chronic Condition
E72.81 is a billable ICD-10-CM diagnosis code for disorders of gamma aminobutyric acid metabolism. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). Coders also document this condition as disorder of beta and omega amino acid metabolism. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Disorder of beta and omega amino acid metabolism
- Disorder of gamma aminobutyric acid metabolism
- Disorder of the gamma-glutamyl cycle
- Gamma-aminobutyric acid transaminase deficiency
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- 4-hydroxybutyric aciduria
- Disorders of GABA metabolism
- GABA metabolic defect
- GABA transaminase deficiency
- GABA-T deficiency
- Gamma-hydroxybutyric aciduria
- SSADHD
- Succinic semialdehyde dehydrogenase deficiency
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Aciduria
- 4-hydroxybutyric - E72.81
- gamma-hydroxybutyric - E72.81
- GABA (gamma aminobutyric acid) metabolic - E72.81
- GABA (gamma aminobutyric acid) transaminase - E72.81
- succinic semialdehyde dehydrogenase - E72.81
- Disorder (of) - See Also: Disease;
- gamma aminobutyric acid (GABA) metabolism - E72.81
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Aciduria
- 4-hydroxybutyric
- Aciduria
- gamma-hydroxybutyric
- Defect, defective
- GABA (gamma aminobutyric acid) metabolic
- Deficiency, deficient
- GABA (gamma aminobutyric acid) transaminase
- Deficiency, deficient
- GABA-T (gamma aminobutyric acid transaminase)
- Deficiency, deficient
- succinic semialdehyde dehydrogenase
- Disorder(of)
- gamma aminobutyric acid (GABA) metabolism
- SSADHD(succinic semialdehyde dehydrogenase deficiency)
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Amino Acid Metabolism Disorders
Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Your digestive system breaks the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Code History & ChangesHistory
Replacement E72.81 replaces the following previously assigned code(s):
- E72.8 - Other specified disorders of amino-acid metabolism
Questions About E72.81Overview
Is E72.81 (Other specified disorders of amino-acid metabolism) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report disorders of gamma aminobutyric acid metabolism on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
