2027 ICD-10-CM Diagnosis Code E72.01Cystinuria
ICD-10-CM Codes›E00–E89›E70-E88›E72
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Chronic Condition
E72.01 is a billable ICD-10-CM diagnosis code for cystinuria. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 642. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 140 closely related codes. Coders also document this condition as atypical hypotonia cystinuria syndrome. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
E72.01 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 42 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E72.01 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Atypical hypotonia cystinuria syndrome
- Cystinuria
- Cystinuria, type 1
- Cystinuria, type 2
- Cystinuria, type 3
- Hypotonia cystinuria syndrome
- Isolated cystinuria
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E72.01: its own notes plus those printed at E72.0, E72, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- disorders of tryptophan metabolism (E70.5)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- Ehlers-Danlos syndromes (Q79.6-)
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E72.01, its category, or a range that includes it.
Excludes1 6
These codes carry an Excludes1 note naming E72.01: they are not reported together with it, unless the two conditions are unrelated.
- E72.1 Disorders of sulfur-bearing amino-acid metabolismcystinuria (E72.01)
- D61.03 Fanconi anemiaFanconi syndrome (E72.0-) names E72.0-, which includes this code
- N29 Other disorders of kidney and ureter in diseases classified elsewherecystinosis (E72.0) names E72.0, which includes this code
- R79 Other abnormal findings of blood chemistry
- R79.83 Abnormal findings of blood amino-acid level
- Block R80-R82 Abnormal findings on examination of urine, without diagnosis
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Cystinuria E72.01
Disorder (of) See Also: Disease;
cystinuria E72.01
cystinuria E72.01
cystine E72.01
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Cystinuria
an inherited disorder due to defective reabsorption of cystine and other basic amino acids by the proximal renal tubules. this form of aminoaciduria is characterized by the abnormally high urinary levels of cystine; lysine; arginine; and ornithine. mutations involve the amino acid transport protein gene slc3a1.
Patient EducationClinical
Kidney Stones
A kidney stone is a solid piece of material that forms in the kidney from substances in the urine. It may be as small as a grain of sand or as large as a pearl. Most kidney stones pass out of the body without help from a doctor. But sometimes a stone will not go away.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E72.01 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E72.01Overview
What is the ICD-10 code for cystinuria?
The ICD-10-CM code for cystinuria is E72.01 (sometimes written as E7201). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E72.01 (Disorders of amino-acid transport) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report cystinuria on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E72.01 group to?
When cystinuria is the principal diagnosis on an inpatient stay, it groups to MS-DRG 642 (inborn and Other Disorders of Metabolism), which carries a relative weight of 1.3226. Higher weights mean higher Medicare reimbursement.
Is E72.01 a CC or MCC?
CMS lists E72.01 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 140 closely related codes in its exclusion list.
Can E72.01 be reported with E70.5?
Not as a rule. The Excludes1 note at E72.0, which applies to E72.01, lists "disorders of tryptophan metabolism (E70.5)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does E72.01 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. E72.01 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 42 (Acromegaly and Other Endocrine and Metabolic Disorders).
