2026 ICD-10-CM Diagnosis Code T45.616AUnderdosing of thrombolytic drugs, initial encounter

ICD-10-CM Codes›S00–T88›T36-T50›T45

ICD-10-CM T45.616A
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

T45.616A is a billable ICD-10-CM diagnosis code for underdosing of thrombolytic drugs, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Underdosing of drugs and medicaments, initial encounter.

Code Identity

ICD-10-CM Code
T45.616A
Billable Status
Yes — Valid for Submission
Code Describes
Underdosing of thrombolytic drugs, initial encounter
Short Description
Underdosing of thrombolytic drugs, initial encounter
Same as the full description in the CMS dataset.
Parent Code
T45.616
Underdosing of thrombolytic drugs

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
CategoryT45Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified
This CodeT45.616AUnderdosing of thrombolytic drugs, initial encounter

Code EditsBilling

Medicare Code Editor checks that affect claim validity for T45.616A.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Coding GuidelinesGuidance

Underdosing refers to taking less of a medication than is prescribed by a provider or a manufacturer's instruction. Codes for underdosing should never be assigned as principal or first-listed codes. If a patient has a relapse or exacerbation of the medical condition for which the drug is prescribed because of the reduction in dose, then the medical condition itself should be coded.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (T45). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ029
Underdosing of drugs and medicaments, initial encounter
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • Anistreplase

    an acylated inactive complex of streptokinase and human lysine-plasminogen. after injection, the acyl group is slowly hydrolyzed, producing an activator that converts plasminogen to plasmin, thereby initiating fibrinolysis. its half-life is about 90 minutes compared to 5 minutes for tpa; (tissue plasminogen activator); 16 minutes for urokinase-type plasminogen activator and 23 minutes for streptokinase. if treatment is initiated within 3 hours of onset of symptoms for acute myocardial infarction, the drug preserves myocardial tissue and left ventricular function and increases coronary artery patency. bleeding complications are similar to other thrombolytic agents.

  • Streptodornase and Streptokinase

    a mixture of the enzymes (streptokinase and streptodornase) produced by hemolytic streptococci. it is used topically on surface lesions and by instillation in closed body cavities to remove clotted blood or fibrinous or purulent accumulations. it is also used as a skin test antigen in evaluating generalized cell-mediated immunodeficiency. (dorland, 27th ed) ec 3.-.

  • Streptokinase

    streptococcal fibrinolysin . an enzyme produced by hemolytic streptococci. it hydrolyzes amide linkages and serves as an activator of plasminogen. it is used in thrombolytic therapy and is used also in mixtures with streptodornase (streptodornase and streptokinase). ec 3.4.-.

Table of Drugs and ChemicalsClinical

Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.

SubstanceAccidentalSelf-harmAssaultUndeter­minedAdverse
Effect		Under­dosing
AlteplaseT45.611T45.612T45.613T45.614T45.615T45.616
AnistreplaseT45.611T45.612T45.613T45.614T45.615T45.616
Fibrinolytic drugT45.611T45.612T45.613T45.614T45.615T45.616
Plasminogen (tissue) activatorT45.611T45.612T45.613T45.614T45.615T45.616
Rt-PAT45.611T45.612T45.613T45.614T45.615T45.616
StreptokinaseT45.611T45.612T45.613T45.614T45.615T45.616
ThrombolysinT45.611T45.612T45.613T45.614T45.615T45.616
UrokinaseT45.611T45.612T45.613T45.614T45.615T45.616

Patient EducationClinical

Medication Errors

Medicines treat infectious diseases, prevent problems from chronic diseases, and ease pain. But medicines can also cause harmful reactions if not used correctly. Errors can happen in the hospital, at the health care provider's office, at the pharmacy, or at home. You can help prevent errors by:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert T45.616A to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
No Map There is no ICD-9 equivalent for this code.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About T45.616AOverview

Is T45.616A (Underdosing of thrombolytic drugs) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report underdosing of thrombolytic drugs, initial encounter on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What does the 7th character A in T45.616A mean?

The final character A marks the initial encounter: use it while the patient is receiving active treatment for underdosing of thrombolytic drugs, such as an emergency visit or first evaluation.

Can T45.616A be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because underdosing of thrombolytic drugs, initial encounter describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.