ICD-10 Code T45.1X6

Underdosing of antineoplastic and immunosuppressive drugs

Version 2019 Replaced Code Non-Billable Code Underdosing

Not Valid for Submission

T45.1X6 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of underdosing of antineoplastic and immunosuppressive drugs. The code is NOT valid for the year 2020 for the submission of HIPAA-covered transactions.

ICD-10: T45.1X6
Short Description:Underdosing of antineoplastic and immunosuppressive drugs
Long Description:Underdosing of antineoplastic and immunosuppressive drugs

Consider the following ICD-10 codes with a higher level of specificity:

  • T45.1X6A - Underdosing of antineoplastic and immunosuppressive drugs, initial encounter
  • T45.1X6D - Underdosing of antineoplastic and immunosuppressive drugs, subsequent encounter
  • T45.1X6S - Underdosing of antineoplastic and immunosuppressive drugs, sequela

Replaced Code

This code was replaced in the 2020 ICD-10 code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2019. This code was replaced for the FY 2020 (October 1, 2019 - September 30, 2020).

  • K59.03 - Drug induced constipation

Code Classification

  • Injury, poisoning and certain other consequences of external causes (S00–T98)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50)
      • Primarily systemic and hematological agents, NEC (T45)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (first year ICD-10-CM implemented into the HIPAA mandated code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Medical Professionals

Table of Drugs and Chemicals

The code T45.1X6 is included in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. Use as many codes as necessary to describe all reported drugs, medicinal or chemical substances.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
self-harm
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
AclarubicinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Actinomycin CT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Actinomycin DT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AdriamycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Alkylating drug NECT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Alkylating drug NEC
  »antimyeloproliferative
T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Alkylating drug NEC
  »lymphatic
T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AltretamineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AmethopterinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AminoglutethimideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Aminopterin sodiumT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AmsacrineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AnthramycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Anticancer agents NECT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AntimetaboliteT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Antimitotic agentT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Antineoplastic NECT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Antineoplastic NEC
  »alkaloidal
T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Antineoplastic NEC
  »antibiotics
T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Antineoplastic NEC
  »combination
T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Antineoplastic NEC
  »combination
    »estrogen
T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Antineoplastic NEC
  »steroid
T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Ara-CT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AsparaginaseT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AzacitidineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AzaribineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AzaserineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AzatepaT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
AzathioprineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
BCNUT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
BenzcarbimineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
BleomycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
BroxuridineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Busulfan, busulphanT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
CactinomycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Cancer chemotherapy drug regimenT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
CarboplatinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
CarboquoneT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
CarmofurT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
CarmustineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
ChlorambucilT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
ChlorhexamideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
ChlormethineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
ChloropurineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Chromomycin A3T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
CiclosporinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
CisplatinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
ColaspaseT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Corynebacterium parvumT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
CycloleucinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
CyclophosphamideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
CyclosporinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
CytarabineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Cytosine arabinosideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
CytoxanT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
DacarbazineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
DactinomycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
DaunomycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
DaunorubicinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
DemecolcineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
2-Deoxy-5-fluorouridineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
5-Deoxy-5-fluorouridineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
DibromodulcitolT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
DibromomannitolT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
DoxifluridineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
DoxorubicinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
DTICT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Elliptinium acetateT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
EnocitabineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
EpirubicinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
EstramustineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
EtoglucidT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
EtoposideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
FAC (fluorouracil + doxorubicin + cyclophosphamide)T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
FloxuridineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
FluorodeoxyuridineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
FluorouracilT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
FtorafurT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
GoldT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Gold
  »colloidal (l98Au)
T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Gold
  »salts
T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
GoserelinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
HexamethylmelamineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
HydroxycarbamideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
HydroxyureaT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
IdarubicinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
IfosfamideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Imidazole-4-carboxamideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Immunosuppressive drugT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
InproquoneT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
IproplatinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
IsophosphamideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
LeukeranT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
LomustineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
LonidamineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
M-AMSAT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MannomustineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MatulaneT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MechlorethamineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MelphalanT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MercaptopurineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MethotrexateT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MetoprineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MithramycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MitobronitolT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MitoguazoneT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MitolactolT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MitomycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MitopodozideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MitotaneT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MitoxantroneT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MopidamolT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MOPP (mechloreth-amine + vincristine + prednisone + procarba-zine)T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Muromonab-CD3T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MustineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
M-vacT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MyelobromalT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
MyleranT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
NimustineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
OlivomycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
OncovinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
ParoxypropioneT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
PentostatinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
PeplomycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Phenylalanine mustardT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
PipobromanT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
PirarubicinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
PlicamycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
PorfiromycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
PrednimustineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
ProcarbazineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
PteroyltriglutamateT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Purine analogue (antineoplastic)T45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
PurinetholT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Pyrimidine antagonistT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
RazoxaneT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
RubidomycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
RufocromomycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
SarcolysinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
SarkomycinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
SemustineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
StreptozocinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
StreptozotocinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TauromustineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TegafurT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TEMT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TeniposideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TEPAT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
ThalidomideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
ThioguanineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
ThiotepaT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TioguanineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TreosulfanT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TretamineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TriaziquoneT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TrichlormethineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TrichlorotriethylamineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TriethanomelamineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TriethylenemelamineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TriethylenephosphoramideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TriethylenethiophosphoramideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TrimetrexateT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TrimustineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
TrofosfamideT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Uracil mustardT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
UramustineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
UrethaneT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
VinblastineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
VincamineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
VincristineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
VindesineT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
Vinorelbine tartrateT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
ZinostatinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6
ZorubicinT45.1X1T45.1X2T45.1X3T45.1X4T45.1X5T45.1X6

Information for Patients


Medication Errors

Medicines treat infectious diseases, prevent problems from chronic diseases, and ease pain. But medicines can also cause harmful reactions if not used correctly. Errors can happen in the hospital, at the health care provider's office, at the pharmacy, or at home. You can help prevent errors by

  • Knowing your medicines. When you get a prescription, ask the name of the medicine and check to make sure that the pharmacy gave you the right medicine. Make sure that you understand how often you should take the medicine and how long you should take it.
  • Keeping a list of medicines.
    • Write down all of the medicines that you are taking, including the names of your medicines, how much you take, and when you take them. Make sure to include any over-the-counter medicines, vitamins, supplements, and herbs that you take.
    • List the medicines that you are allergic to or that have caused you problems in the past.
    • Take this list with you every time you see a health care provider.
  • Reading medicine labels and following the directions. Don't just rely on your memory - read the medication label every time. Be especially careful when giving medicines to children.
  • Asking questions. If you don't know the answers to these questions, ask your health care provider or pharmacist:
    • Why am I taking this medicine?
    • What are the common side effects?
    • What should I do if I have side effects?
    • When should I stop this medicine?
    • Can I take this medicine with the other medicines and supplements on my list?
    • Do I need to avoid certain foods or alcohol while taking this medicine?

Food and Drug Administration


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ICD-10 Footnotes

General Equivalence Map Definitions
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Approximate Flag - The approximate flag is on, indicating that the relationship between the code in the source system and the code in the target system is an approximate equivalent.
  • No Map Flag - The no map flag indicates that a code in the source system is not linked to any code in the target system.
  • Combination Flag - The combination flag indicates that more than one code in the target system is required to satisfy the full equivalent meaning of a code in the source system.